☆ 4.2 Article

A case of pan-resistant Burkholderia cepacia complex bacteremic pneumonia, after lung transplantation treated with a targeted combination therapy

TRANSPLANT INFECTIOUS DISEASE (2019)

Journal

TRANSPLANT INFECTIOUS DISEASE

Volume 21, Issue 2, Pages -

Publisher

WILEY

DOI: 10.1111/tid.13034

Keywords

bacteraemic pneumonia; lung transplantation; pan-resistant Burkholderia Cepacia complex

Categories

Immunology Infectious Diseases Transplantation

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Abstract

We describe a case of one patient with cystic fibrosis who developed a pan-resistant Burkholderia cepacia complex rapidly progressive bacteraemic pneunonia, following bilateral lung transplantation. The patient was treated with a targeted combination antibiotic therapy (meropenem plus ceftazidime/avibactam plus high doses of nebulized colistimethate sodium). Evolution of the disease was complicated by multiple organ system dysfunction. Finally, clinical improvement and microbiological cure was achieved.

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