The Emergence of Microphysiological Systems (Organs-on-chips) as Paradigm-changing Tools for Toxicologic Pathology

3S - Systematic, systemic, and systems biology and toxicology

(2018) Lena Smirnova   ALTEX-Alternatives to Animal Experimentation

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Organs-on-chips: Progress, challenges, and future directions

(2017) Lucie A Low et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology

(2017) David E Watson et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

(2017) Lorna Ewart et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems

(2017) David J Hughes et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Strategic Focus on 3R Principles Reveals Major Reductions in the Use of Animals in Pharmaceutical Toxicity Testing

(2014) Elin Törnqvist et al.   PLoS One

The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline

(2013) Margaret L Sutherland et al.   Stem Cell Research & Therapy

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE