Article
Medicine, General & Internal
Wen Shi, Yan Zheng, Shuai Luo, Xiaofeng Li, Yilong Zhang, Xiaoming Meng, Cheng Huang, Jun Li
Summary: METTL3 plays a crucial role in rheumatoid arthritis by promoting FLS activation and inflammatory response via the NF-kappa B signaling pathway.
FRONTIERS IN MEDICINE
(2021)
Article
Orthopedics
Shuo Zhang, Tao Zhang, Yayun Xu, Genxiang Rong, Juehua Jing
Summary: In patients with rheumatoid arthritis, the levels of NUCB2 mRNA are significantly elevated in the synovium and are associated with gene signatures related to the cell cycle and DNA replication. Inhibition of NUCB2 effectively suppresses the proliferation, migration, and invasion of RASFs.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Immunology
Li-ping Dai, Xiao-dong Xu, Ting-ting Yang, Zhi-hua Yin, Zhi-zhong Ye, Ya-zhi Wei
Summary: This study investigated the potential mechanism of SPTBN1 in rheumatoid arthritis (RA) and found that SPTBN1 could inhibit disease progression and alleviate cell proliferation, migration, invasion, and inflammation through its interaction with PIK3R2.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Pharmacology & Pharmacy
Yongli Zhang, Luna Ge, Guanhua Song, Ruojia Zhang, Shufeng Li, Haojun Shi, Hongchang Zhang, Yi Li, Jihong Pan, Lin Wang, Jinxiang Han
Summary: Azithromycin, a macrolide antibiotic with anti-inflammatory properties, has shown promising treatment potential in reducing inflammation in rheumatoid arthritis patients. It affects signaling cascades associated with cholesterol and lipid biosynthesis, and targets GRP78, playing a key role in anti-arthritic activity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Rheumatology
Jiajie Tu, Weile Chen, Yilong Fang, Dafei Han, Yizhao Chen, Haifeng Jiang, Xuewen Tan, Zhen Xu, Xuming Wu, Huihui Wang, Xiangling Zhu, Wenming Hong, Zhenbao Li, Chen Zhu, Xinming Wang, Wei Wei
Summary: This study investigates the function and mechanism of PU.1, a crucial transcription factor, in the development of rheumatoid arthritis (RA). The results demonstrate the role of PU.1 in RA and suggest that targeting PU.1 could be a potential therapeutic approach by repressing FLT3.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Oncology
Hao Gao, Baobao Cai, Zipeng Lu, Guangfu Wang, Yong Gao, Yi Miao, Kuirong Jiang, Kai Zhang
Summary: This study reveals that STK31 is reactivated in pancreatic cancer and associated with poor prognosis. It promotes the progression of pancreatic cancer by facilitating cell proliferation, migration, and invasion, and is regulated by methylation.
Article
Immunology
Yayun Xu, Zheng Lu, Yian Ling, Ruirui Hou, Jingjing Tao, Ge Deng, Xiaoling Xu, Xuewei Chen, Jingjing Ruan, Yihao Zhang, Xiaoqing Peng, Feihu Chen
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and joint destruction. Activated rheumatoid arthritis synovial fibroblasts (RASFs) exhibit tumor-like features. This study found that activation of acid-sensing ion channel 1a (ASIC1a) in an acidic environment promotes the proliferation of RASFs, which may involve the Wnt/β-catenin/c-Myc pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Chang Jiang, Qun Yang, Bo Wang, Jun Yang, Linan Li, Xiliang Tian, Yang Liu
Summary: In rheumatoid arthritis (RA), the long non-coding RNA HOTAIR is significantly upregulated while miRNA526b-3p is downregulated in patients compared to healthy individuals. Inhibiting HOTAIR expression can lead to reduced proliferative, migrative, invasive capabilities, and inflammatory factor secretion of RASFs. Therefore, targeting the HOTAIR-miRNA526b-3p axis could be a potential therapeutic strategy for RA.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Review
Rheumatology
Tamas Nemeth, Gyorgy Nagy, Thomas Pap
Summary: Fibroblast-like synoviocytes (FLS) are crucial cellular components in the synovial membrane of joints, contributing to normal joint function. However, under inflammatory conditions like rheumatoid arthritis (RA), FLS can become overactive and promote inflammation. Therefore, understanding the role of FLS in RA is essential for disease treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Oncology
Sainan Liu, Bin Liu, Qian Zhao, Jikang Shi, Yulu Gu, Yanbo Guo, Yong Li, Yunkai Liu, Yi Cheng, Yichun Qiao, Yawen Liu
Summary: The study found that low FST expression is associated with poor prognosis of patients with TNBC, and FST exhibits heterogeneous roles in apoptosis in different subtypes of TNBC cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Ying Zhan, Wei Qiao, Bolong Yi, Xinyu Yang, Miaomiao Li, Lu Sun, Lian Ji, Peng Su, Xin Wang, Furong Zhang, Rui Zhang, Mingjun Gao, Wujun Zhao, Yichen Song
Summary: This study found that TMEM198B promotes the malignant progression of glioma by regulating lipid metabolism reprogramming and remodeling immune microenvironment. TMEM198B increases PLAGL2 expression, which activates ACLY and ELOVL6, influencing the behavior of glioma cells. Additionally, TMEM198B promotes M2 polarization of macrophages via glioma-derived exosomes, further facilitating immune escape of glioma cells.
Review
Endocrinology & Metabolism
Carmen Clapp, Georgina Ortiz, Jose F. Garcia-Rodrigo, Maria G. Ledesma-Colunga, Oscar F. Martinez-Diaz, Norma Adan, Gonzalo Martinez de la Escalera
Summary: Inflammatory arthritis is a group of diseases caused by an overactive immune system, influenced by host factors, such as sex and stress. Prolactin (PRL), a hormone associated with rheumatoid arthritis (RA), has both positive and negative effects on the disease. This review focuses on the PRL/vasoinhibin axis, discussing its role in joint inflammation and the pathophysiology of RA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joanna Szuszkiewicz, Kamil Myszczynski, Zaneta P. Reliszko, Yael Heifetz, Monika M. Kaczmarek
Summary: Research has shown that during early pregnancy, communication between the embryo and uterus occurs through the exchange of extracellular vesicles carrying miRNAs. These vesicles impact embryonic development and trophoblast cell function and interactions, playing a crucial role in successful embryo implantation and pregnancy.
Article
Rheumatology
Raphael Micheroli, Muriel Elhai, Sam Edalat, Mojca Frank-Bertoncelj, Kristina Buerki, Adrian Ciurea, Lucy MacDonald, Mariola Kurowska-Stolarska, Myles J. Lewis, Katriona Goldmann, Cankut Cubuk, Tadeja Kuret, Oliver Distler, Costantino Pitzalis, Caroline Ospelt
Summary: This study integrated single-cell RNA sequencing data to assess the contribution of synovial fibroblast subsets to synovial pathotypes and clinical characteristics in treatment-naive early arthritis. The findings revealed a previously unexplored association between specific synovial pathologies and subtypes of synovial fibroblasts.
Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)