Article
Cell & Tissue Engineering
Yang Zhou, Bo Zhao, Xin-Liao Zhang, Yi-jun Lu, Shou-Tao Lu, Jian Cheng, Yu Fu, Lin Lin, Ning-Yan Zhang, Pei-Xin Li, Jing Zhang, Jun Zhang
Summary: This study investigated the potential clinical application roles of human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes (hADSC-Exo) in cutaneous wound healing. The combined administration of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration showed additional benefits in promoting wound healing, accelerating re-epithelialization, reducing scar widths, and enhancing angiogenesis and collagen synthesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Yang Zhou, Xing-Liao Zhang, Shou-Tao Lu, Ning-Yan Zhang, Hai-Jun Zhang, Jing Zhang, Jun Zhang
Summary: This study explores the potential clinical application of hADSCs-Exos encapsulated in PF-127 hydrogel for wound healing. The results showed that PF-127/hADSCs-Exos complexes enhanced skin wound healing, promoted re-epithelialization, increased collagen synthesis and expression of skin barrier proteins, and reduced inflammation. Using PF-127/hADSCs-Exos complexes allows for lower doses and frequency of exosome administration while maintaining therapeutic effects.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Shune Xiao, Chunfang Xiao, Yong Miao, Jin Wang, Ruosi Chen, Zhexiang Fan, Zhiqi Hu
Summary: The study demonstrated that hAAM scaffolds incorporated with ADSC-Exos can promote diabetic skin wound healing by regulating inflammation, stimulating vascularization, and promoting the production of extracellular matrix.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jun Ho Lee, Yu Jin Won, Hail Kim, Minji Choi, Esther Lee, Bumsik Ryoou, Seok-Geun Lee, Byong Seung Cho
Summary: Exosomes derived from adipose tissue-derived stem cells (ASCs) have shown beneficial effects on cell proliferation, migration, and gene expression related to wound healing. Combining these ASC-derived exosomes (ASC-EXOs) with hyaluronic acid (HA) can enhance wound closure rates, tissue regeneration, and collagen production in animal models. This suggests the potential for their use in clinical and regenerative aesthetic applications for skin repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Feiyu Cai, Wenjiao Chen, Ruomei Zhao, Yi Liu
Summary: This paper provides an academic review of the therapeutic effects of adipose-derived stem cell-EXOs (ADSC-EXOs) in diabetic wound healing. As cell-free therapy, exosomes (EXOs) contain proteins and growth factors that can promote wound healing and mitigate potential risks associated with stem cell therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yanling Song, Yuchan You, Xinyi Xu, Jingyi Lu, Xiajie Huang, Jucong Zhang, Luwen Zhu, Jiahao Hu, Xiaochuan Wu, Xiaoling Xu, Weiqiang Tan, Yongzhong Du
Summary: The ECM@exo treatment, which incorporates ADSC-exos into an ECM hydrogel, shows great potential in promoting wound healing by reducing inflammation, enhancing cell proliferation and migration, as well as promoting angiogenesis and collagen deposition.
Article
Pharmacology & Pharmacy
Hsiang-Hao Hsu, Aline Yen Ling Wang, Charles Yuen Yung Loh, Ashwin Alke Pai, Huang-Kai Kao
Summary: This study found that diabetic ASC-Exo enhance cutaneous wound healing by stimulating dermal cell proliferation, keratinocyte proliferation, and angiogenesis. The diabetic ASC-Exo also stimulate resident monocytes/macrophages to secrete more TGF-beta 1 and activate the TGF-beta/Smad3 signaling pathway.
Article
Cell & Tissue Engineering
Nesrine Ebrahim, Arigue A. Dessouky, Ola Mostafa, Amira Hassouna, Mohamed M. Yousef, Yasmin Seleem, Eman Abd El Aziz M. El Gebaly, Mona M. Allam, Ayman Samir Farid, Bayan A. Saffaf, Dina Sabry, Ahmed Nawar, Ahmed A. Shoulah, Ahmed H. Khalil, Sami F. Abdalla, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Rabab F. Salim
Summary: The combined therapy of PRP and ADSCs significantly accelerated wound healing in experimentally induced diabetic rats by modulating the Notch signaling pathway, promoting angiogenesis, and enhancing EPSC proliferation.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Margherita Pomatto, Chiara Gai, Federica Negro, Massimo Cedrino, Cristina Grange, Elena Ceccotti, Gabriele Togliatto, Federica Collino, Marta Tapparo, Federico Figliolini, Tatiana Lopatina, Maria Felice Brizzi, Giovanni Camussi
Summary: Research demonstrates that EVs derived from adipose tissue have a positive impact on diabetic wound healing, while those from bone marrow primarily promote cell proliferation. Significant differences exist in the molecular cargo of these two types of EVs, with ADSC-EVs showing greater angiogenic effects, and BMSC-EVs being more inclined towards cellular proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Yang An, Shuyan Lin, Xiaojie Tan, Shiou Zhu, Fangfei Nie, Yonghuan Zhen, Luosha Gu, Chunlei Zhang, Baicheng Wang, Wei Wei, Dong Li, Junhao Wu
Summary: ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling to inhibit scar hyperplasia in wounds. Compared with ADSCs therapeutics, ADSCs-EXOs have high stability, easy storage, immune system non-rejection, homing effect, and easily controlled dosage. In patients with diabetes mellitus, ADSCs-EXOs can improve fat grafting and promote wound healing.
CELL PROLIFERATION
(2021)
Article
Nanoscience & Nanotechnology
Honghao Yu, Yiping Wu, Boyu Zhang, Mingchen Xiong, Yi Yi, Qi Zhang, Min Wu
Summary: This study demonstrated that E2F1-deficient ADSC-Exos promote wound healing by enhancing collagen formation and angiogenesis, and by regulating miRNA to enhance fibroblast activities. This finding provides a novel strategy of gene-engineered stem cell exosomes for accelerating wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Zhaoyang Chen, Bowen Zhang, Jun Shu, Haiyang Wang, Yudi Han, Quan Zeng, Youbai Chen, Jiafei Xi, Ran Tao, Xuetao Pei, Wen Yue, Yan Han
Summary: Biological scaffolds based stem cell delivery using a hydrogel made from human decellularized adipose matrix show promising results in accelerating chronic wound healing. The hydrogel supports survival and proliferation of stem cells, and enhances paracrine activity. In diabetic mouse model experiments, the composite treatment led to faster wound closure and increased neovascularization.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Cell Biology
Jiachao Xiong, Hong Qiang, Ting Li, Jiayi Zhao, Ziyu Wang, Fei Li, Jianwen Xu
Summary: The study demonstrates that human adipose-derived stem cells can promote the vascularization of seawater-treated wounds by differentiating into vascular endothelial cells and promoting their proliferation and migration. Bioinformatics analysis identified genes that may regulate wound healing mechanisms such as extracellular matrix remodeling, programmed cell death, inflammation, and vascularization.
Review
Biochemistry & Molecular Biology
Dimitris Tatsis, Varvara Vasalou, Efstathios Kotidis, Elissavet Anestiadou, Ioannis Grivas, Angeliki Cheva, Georgios Koliakos, Gregory Venetis, Manousos-George Pramateftakis, Nikolaos Ouzounidis, Stamatis Angelopoulos
Summary: This review discusses the synergistic effects of platelet-rich plasma (PRP) and adipose-derived mesenchymal stem cells (ADMSCs) in wound healing, recording experimental studies and discussing technical aspects and major results. Limited clinical studies involving humans are also reported. Future perspectives and the limitations of current studies are discussed, including the need for long-term follow up on efficacy and safety.
Article
Cell Biology
So-Young Chang, Jun Hee Lee, Se Cheol Oh, Min Young Lee, Nam Kyu Lim
Summary: Diabetes mellitus is a major cause of chronic foot ulcers, and cell-based therapies using adipose-derived stem cells (ADSCs) show potential in promoting wound healing and blood flow in diabetic foot disease. This study confirmed the effectiveness of enhanced human ADSCs (ehADSCs) with a cocktail of FGF and other pharmacological agents in vitro and in vivo. The ehADSCs exhibited better proliferation, oxidative stress tolerance, stemness, and mobility, and their injection into diabetic wounds enhanced wound healing, blood flow, and revascularization markers.
