Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties

Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors

(2018) Jingci Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of osteoblast maturation on their paracrine growth enhancing activity on cord blood progenitors

(2017) Manal Alsheikh et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Human Bone Marrow Mesenchymal Stromal Cell-Derived Osteoblasts Promote the Expansion of Hematopoietic Progenitors Through Beta-Catenin and Notch Signaling Pathways

(2017) Matthew Michalicka et al.   STEM CELLS AND DEVELOPMENT

Paternal Insulin-like Growth Factor 2 ( Igf2) Regulates Stem Cell Activity During Adulthood

(2017) Vilma Barroca et al.   EBioMedicine

Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification

(2016) K. D. Kokkaliaris et al.   BLOOD

Characterization of the growth modulatory activities of osteoblast conditioned media on cord blood progenitor cells

(2016) Ahmad Abu-Khader et al.   CYTOTECHNOLOGY

Early production of human neutrophils and platelets posttransplant is severely compromised by growth factor exposure

(2016) Paul H. Miller et al.   EXPERIMENTAL HEMATOLOGY

Notch-Expanded Murine Hematopoietic Stem and Progenitor Cells Mitigate Death from Lethal Radiation and Convey Immune Tolerance in Mismatched Recipients

(2016) Filippo Milano et al.   Stem Cells Translational Medicine

Aberrant Wnt Signaling in Leukemia

(2016) Frank Staal et al.   Cancers

Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation

(2015) U. Popat et al.   BLOOD

Cellular engineering and therapy in combination with cord blood allografting in pediatric recipients

(2015) M S Cairo et al.   BONE MARROW TRANSPLANTATION

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities

(2015) Koen Schepers et al.   Cell Stem Cell

Phenotypic and functional comparison of mobilized peripheral blood versus umbilical cord blood megakaryocyte populations

(2015) Joshua Kellner et al.   CYTOTHERAPY

Advances in umbilical cord blood stem cell expansion and clinical translation

(2015) Nicolas Pineault et al.   EXPERIMENTAL HEMATOLOGY

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies

(2015) Varsha P. Brahmkhatri et al.   Biomed Research International

CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche

(2014) B. R. Chitteti et al.   BLOOD

Medium conditioned with mesenchymal stromal cell–derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors

(2014) Nellie Dumont et al.   EXPERIMENTAL HEMATOLOGY

Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment

(2014) Mitchell E. Horwitz et al.   JOURNAL OF CLINICAL INVESTIGATION

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

(2014) I. Fares et al.   SCIENCE

Apc regulates the function of hematopoietic stem cells largely through  -catenin-dependent mechanisms

(2013) W. Li et al.   BLOOD

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation

(2013) C. Cutler et al.   BLOOD

Hierarchical organization of osteoblasts reveals the significant role of CD166 in hematopoietic stem cell maintenance and function

(2013) Brahmananda R. Chitteti et al.   BONE

Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence

(2013) Aparna Venkatraman et al.   NATURE

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

Co-Culture of Hematopoietic Stem/Progenitor Cells with Human Osteblasts Favours Mono/Macrophage Differentiation at the Expense of the Erythroid Lineage

(2013) Simona Salati et al.   PLoS One

IGF-1-mediated osteoblastic niche expansion enhances long-term hematopoietic stem cell engraftment after murine bone marrow transplantation

(2013) Anna Caselli et al.   STEM CELLS

Cord blood-hematopoietic stem cell expansion in 3D fibrin scaffolds with stromal support

(2012) Mónica S. Ventura Ferreira et al.   BIOMATERIALS

Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation

(2012) A. M. S. Cheung et al.   BLOOD

Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγnull mice

(2012) Simon N. Robinson et al.   EXPERIMENTAL HEMATOLOGY

Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture

(2012) Marcos de Lima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Characterization of TPO-Expanded CD34+Cord Blood Cells Identifies CD34−CD61−Cells as Platelet-Producing Cells Early After Transplantation in NOD/SCID Mice and rCD34+Cells as CAFC Colony-Forming Cells

(2012) Laurus F. Schipper et al.   STEM CELLS

Alcam Regulates Long-Term Hematopoietic Stem Cell Engraftment and Self-Renewal

(2012) Robin Jeannet et al.   STEM CELLS

Cotransplantation of Ex Vivo Expanded Progenitors with Nonexpanded Cord Blood Cells Improves Platelet Recovery

(2012) Hélène Émond et al.   STEM CELLS AND DEVELOPMENT

Synergistic effects of growth factors and mesenchymal stromal cells for expansion of hematopoietic stem and progenitor cells

(2011) Thomas Walenda et al.   EXPERIMENTAL HEMATOLOGY

Irradiated mesenchymal stem cells improve the ex vivo expansion of hematopoietic progenitors by partly mimicking the bone marrow endosteal environment

(2011) Betül Çelebi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

(2011) F. C. Gonsalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

(2011) F. Notta et al.   SCIENCE

Individual and synergistic cytokine effects controlling the expansion of cord blood CD34+ cells and megakaryocyte progenitors in culture

(2010) Nicolas Pineault et al.   CYTOTHERAPY

Effective ex vivo expansion of hematopoietic stem cells using osteoblast-differentiated mesenchymal stem cells is CXCL12 dependent

(2010) Seiji Mishima et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Maintenance of HSC by Wnt5a secreting AGM-derived stromal cell line

(2010) Shannon M. Buckley et al.   EXPERIMENTAL HEMATOLOGY

β-catenin mediates insulin-like growth factor-I actions to promote cyclin D1 mRNA expression, cell proliferation and survival in oligodendroglial cultures

(2010) Ping Ye et al.   GLIA

Infusion of mature megakaryocytes into mice yields functional platelets

(2010) Rudy Fuentes et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

(2010) Colleen Delaney et al.   NATURE MEDICINE

The Ins and Outs of Hematopoietic Stem Cells: Studies to Improve Transplantation Outcomes

(2010) Leah A. Marquez-Curtis et al.   Stem Cell Reviews and Reports

Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation

(2009) M. Dominici et al.   BLOOD

Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation

(2009) J. Hoggatt et al.   BLOOD

Mesenchymal stem cells in hematopoietic stem cell transplantation

(2009) Minoo Battiwalla et al.   CYTOTHERAPY

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS