G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

(2017) Yi Zheng et al.   IMMUNITY

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

A kinetic view of GPCR allostery and biased agonism

(2017) J Robert Lane et al.   Nature Chemical Biology

A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias

(2016) Daniele Bolognini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of kinetic context in apparent biased agonism at GPCRs

(2016) Carmen Klein Herenbrink et al.   Nature Communications

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

(2015) Maria Hauge et al.   Molecular Metabolism

Potent Anti-HIV Chemokine Analogs Direct Post-Endocytic Sorting of CCR5

(2015) Claudia Bönsch et al.   PLoS One

Coordinate-based co-localization-mediated analysis of arrestin clustering upon stimulation of the C–C chemokine receptor 5 with RANTES/CCL5 analogues

(2014) Laura Tarancón Díez et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Targeting Spare CC Chemokine Receptor 5 (CCR5) as a Principle to Inhibit HIV-1 Entry

(2014) Jun Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCR5 Conformations Are Dynamic and Modulated by Localization, Trafficking and G Protein Association

(2014) Ayanna J. Flegler et al.   PLoS One

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The calcium feedback loop and T cell activation: How cytoskeleton networks control intracellular calcium flux

(2013) Noah Joseph et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Quantitative morphological analysis of arrestin2 clustering upon G protein-coupled receptor stimulation by super-resolution microscopy

(2013) Zinnia Truan et al.   JOURNAL OF STRUCTURAL BIOLOGY

HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines

(2013) Philippe Colin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

(2011) Brady K Atwood et al.   BMC GENOMICS

Multiple CCR5 Conformations on the Cell Surface Are Used Differentially by Human Immunodeficiency Viruses Resistant or Sensitive to CCR5 Inhibitors

(2011) R. Berro et al.   JOURNAL OF VIROLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation

(2009) Jacob Ngai et al.   BMC IMMUNOLOGY

Functional Selectivity of Natural and Synthetic Prostaglandin EP4 Receptor Ligands

(2009) M. Leduc et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Highly potent, fully recombinant anti-HIV chemokines: Reengineering a low-cost microbicide

(2008) H. Gaertner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly potent HIV inhibition: engineering a key anti-HIV structure from PSC-RANTES into MIP-1 /CCL4

(2008) H. Gaertner et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Targeting Chemokine Receptors in HIV: A Status Report

(2007) Shawn E. Kuhmann et al.   Annual Review of Pharmacology and Toxicology