Article
Neurosciences
Arkadiusz Komorowski, Matej Murgas, Ramon Vidal, Aditya Singh, Gregor Gryglewski, Siegfried Kasper, Jens Wiltfang, Rupert Lanzenberger, Roberto Goya-Maldonado
Summary: The exploration of the spatial relationship between gene expression profiles and task-evoked response patterns known to be altered in neuropsychiatric disorders can guide the development of more targeted therapies. The identification of stable relationships between spatial gene expression profiles and fMRI data may reshape the prospects for imaging transcriptomics studies.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Qi Liu, Benjamin A. Ely, Joshua J. Schwartz, Carmen M. Alonso, Emily R. Stern, Vilma Gabbay
Summary: This study found that lack of pleasure (anhedonia) in adolescent patients with depression may be a predictor of future depression and suicidal ideation. Specifically, activation in the left angular gyrus was associated with future depression, while activation in key salience and pain network regions was associated with future anhedonia.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Developmental
Katia M. Harle, Tiffany C. Ho, Colm G. Connolly, Alan Simmons, Tony T. Yang
Summary: Unforeseen obstacles disrupting reward seeking behavior can lead to negative affect in adolescents, potentially contributing to the development of depression. However, the neurocognitive mechanisms underlying this impact on reward processing in adolescent depression have not been characterized. This study uses neuroimaging and a novel paradigm to examine how incidental action obstruction affects reward-based decision making. Rating: 7 out of 10.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Clemens Mielacher, Dirk Scheele, Maximilian Kiebs, Laura Schmitt, Torge Dellert, Alexandra Philipsen, Claus Lamm, Rene Hurlemann
Summary: This study found that there are altered neural responses to social touch in patients with major depressive disorder (MDD). Despite clinical improvements after antidepressant treatment, MDD patients still showed aversion to interpersonal touch and reduced brain responses in areas such as the nucleus accumbens compared to healthy controls. These findings reveal the abnormal processing of social touch in MDD, which may contribute to social withdrawal and isolation.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
C. E. Schiller, E. Walsh, T. A. Eisenlohr-Moul, J. Prim, G. S. Dichter, L. Schiff, J. Bizzell, S. L. Slightom, E. C. Richardson, A. Belger, P. Schmidt, D. R. Rubinow
Summary: This double-blinded pharmaco-fMRI study shows that adding back and withdrawing hormones increases anhedonia in women without pleasure. Both hormone sensitive and non-hormone sensitive individuals exhibit decreased reward-related brain function during withdrawal.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Sanja Klein, Onno Kruse, Isabell Tapia Leon, Lukas Van Oudenhove, Sophie R. van 't Hof, Tim Klucken, Tor D. Wager, Rudolf Stark
Summary: Sharing and comparing imaging data across psychological tasks is becoming more feasible with the advancement of open science movement. This study validates the commonalities between aversive and appetitive classical conditioning through a multivariate approach, providing an empirical method to integrate fMRI findings across paradigms.
Article
Psychology, Clinical
Gabrielle Liverant, Kimberly A. Arditte Hall, Sarah T. Wieman, Suzanne L. Pineles, Diego A. Pizzagalli
Summary: This study found that among individuals with depression, insomnia is associated with decreased ability to learn associations between neutral stimuli and rewarding outcomes, which may contribute to decreases in motivation and increased withdrawal. This highlights impairments in reward learning as a potential mediator of the association between insomnia and depression.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neuroimaging
Qi Liu, Benjamin A. Ely, Emily R. Stern, Junqian Xu, Joo-won Kim, Danielle G. Pick, Carmen M. Alonso, Vilma Gabbay
Summary: Reward dysfunction plays a key role in the development of psychiatric conditions in adolescence. A study using the Reward Flanker fMRI Task found that reward expectancy activates certain brain regions, while reward attainment leads to deactivation in these regions. Additionally, reward expectancy activation is negatively correlated with anxiety severity, while reward attainment activation is positively correlated with both anxiety and depression severity.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Alyssa N. Fassett-Carman, Amelia D. Moser, Luka Ruzic, Chiara Neilson, Jenna Jones, Sofia Barnes-Horowitz, Christopher D. Schneck, Roselinde H. Kaiser
Summary: This study examines the role of reward sensitivity in buffering the link between life stressors and depressive symptoms. The results show that activation in the amygdala and nucleus accumbens during reward anticipation attenuates the stress-depression relation. This suggests that reward motivation may be a cognitive mechanism through which stress buffering occurs.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Sebastian P. H. Speer, Christian Keysers, Judit Campdepadros Barrios, Cas J. S. Teurlings, Ale Smidts, Maarten A. S. Boksem, Tor D. Wager, Valeria Gazzola
Summary: The processing of reinforcers and punishers is essential for adaptation, but dysregulation is common in mental health and substance use disorders. Previous studies on reward-related brain measures have focused on individual regions, but recent research suggests that affective and motivational processes are encoded in distributed systems across multiple regions. Therefore, predictive models based on distributed patterns yield larger effect sizes and excellent reliability. This study successfully created a Brain Reward Signature (BRS) that accurately predicts brain responses to rewards and losses in active decision-making tasks.
Article
Neurosciences
Zachary Adam Yaple, Serenella Tolomeo, Rongjun Yu
Summary: This study investigated prediction error processing in depression and schizophrenia patients through meta-analyses, finding differences in brain activity between the two patient groups, suggesting a potential role of dopamine-rich areas in encoding prediction errors in both disorders.
HUMAN BRAIN MAPPING
(2021)
Article
Psychology, Clinical
Paola Fuentes-Claramonte, Maria Angeles Garcia-Leon, Pilar Salgado-Pineda, Nuria Ramiro, Joan Soler-Vidal, Maria Llanos Torres, Ramon Cano, Isabel Argila-Plaza, Francesco Panicali, Carmen Sarri, Nuria Jaurrieta, Manel Sanchez, Ester Boix-Quintana, Auria Albacete, Teresa Maristany, Salvador Sarro, Joaquim Radua, Peter. J. McKenna, Raymond Salvador, Edith Pomarol-Clotet
Summary: The negative symptoms of schizophrenia may be due to reduced responsiveness to rewarding stimuli, which is associated with abnormal dopamine function in the disorder. However, few imaging studies have examined whether patients with negative symptoms show reduced activation related to reward prediction error (RPE). The findings suggest that negative symptoms are not caused by a generalized reduction in RPE signaling, but rather by specific dysfunction in the lateral frontal and possibly the orbitofrontal cortex.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Biological
Ming-Ray Liao, Andy J. Kim, Brian A. Anderson
Summary: Reward learning can guide attention to specific regions in a scene, and this study found that it is supported by neural mechanisms in various brain regions. Participants learned to focus on a high-value quadrant in a scene to maximize monetary gains, and during a subsequent test, they were faster at identifying targets in the high-value quadrant. fMRI analyses revealed learning-dependent priority signals in several brain regions associated with attention and spatial processing. These findings provide new insights into the neural architecture of value-driven attention and expand our understanding of the brain networks involved in this process.
Article
Clinical Neurology
Hans Kirschner, Matthew R. Nassar, Adrian G. Fischer, Thomas Frodl, Gabriela Meyer-Lotz, Soeren Froboese, Stephanie Seidenbecher, Tilmann A. Klein, Markus Ullsperger
Summary: Deficits in reward learning are core symptoms in many mental disorders. This study investigates the neuro-computational mechanisms behind these impairments and explores whether they are shared across forms of psychopathology. The findings suggest that reduced trial-by-trial learning dynamics reflect a common deficit in both depression and schizophrenia, but also identify disorder-specific learning deficits.
Article
Neurosciences
A. Wiehler, K. Chakroun, J. Peters
Summary: Research suggests that individuals with gambling disorder show specific deficits in exploration strategy, possibly linked to altered processing in a fronto-parietal network and/or changes in dopamine neurotransmission in the midbrain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Aki Rintala, Martien Wampers, Ginette Lafit, Inez Myin-Germeys, Wolfgang Viechtbauer
Summary: This study investigated the level of disturbance and its predictors in participants using experience sampling method (ESM) through a pooled dataset analysis. The findings suggest that high-frequency ESM protocols can be used in mental health research, but researchers should be aware of the possible disturbance caused by their research design.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Anita Schick, Ruud van Winkel, Bochao D. Lin, Jurjen J. Luykx, Sonja M. C. de Zwarte, Kristel R. van Eijk, Group Investigators, Inez Myin-Germeys, Ulrich Reininghaus
Summary: This study aimed to investigate the impact of polygenic risk on stress reactivity in individuals with psychosis, their relatives, and controls. The results showed that polygenic risk score modified the associations between momentary stress and psychotic experiences, suggesting that it may amplify reactivity to stress in unaffected individuals but attenuate stress reactivity in relatives. These findings suggest that polygenic risk operates differently than previously assumed.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Ymkje Anna de Vries, Robert A. Schoevers, Julian P. T. Higgins, Marcus R. Munafo, Jojanneke A. Bastiaansen
Summary: Statistical power is generally low in trials of psychotherapy, pharmacotherapy, and complementary and alternative medicine for mood, anxiety, and psychotic disorders. Underpowered studies tend to produce larger effect sizes, indicating the presence of reporting bias. Increasing sample sizes and reducing bias are necessary to improve the reliability of published literature in this field.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Karlijn S. F. M. Hermans, Olivia J. Kirtley, Zuzana Kasanova, Robin Achterhof, Noemi Hagemann, Anu P. Hiekkaranta, Aleksandra Lecei, Leonardo Zapata-Fonseca, Ginette Lafit, Ruben Fossion, Tom Froese, Inez Myin-Germeys
Summary: The study examined the ecological and convergent validity of the Perceptual Crossing Experiment (PCE) in a sample of 208 adolescents, finding that only self-reported social skills were positively associated with daily social experiences, failing to support the ecological and convergent validity of the PCE.
Article
Psychology, Developmental
Noemi Hagemann, Olivia J. Kirtley, Ginette Lafit, Davy Vancampfort, Martien Wampers, Jeroen Decoster, Catherine Derom, Sinan Guloksuz, Marc De Hert, Nele Jacobs, Claudia Menne-Lothmann, Bart P. F. Rutten, Evert Thiery, Jim van Os, Ruud van Winkel, Marieke Wichers, Inez Myin-Germeys
Summary: This study examined the impact of coping styles and locus of control on daily sleep quality. The findings showed that disengagement, passive reaction, and emotion-focused coping were associated with poorer sleep quality, while state locus of control did not mediate these effects. These results suggest the importance of considering coping strategies in young individuals with sleep problems.
JOURNAL OF ADOLESCENCE
(2023)
Correction
Psychiatry
Wesley Chor-yin Tang, Corine Sau-man Wong, Ting-yat Wong, Christy Lai-ming Hui, Stephanie Ming -yin Wong, Yi-nam Suen, Sherry Kit-wa Chan, Wing-chung Chang, Edwin Ho-ming Lee, Simon Sai-yu Lui, Kai -tai Chan, Michael Tak-hing Wong, Inez Myin-Germeys, Eric Yu-hai Chen
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Lena de Thurah, Glenn Kiekens, Rob Sips, Ana Teixeira, Zuzana Kasanova, Inez Myin-Germeys
Summary: The Experience sampling method (ESM) has the potential to support person-centered care of psychotic disorders, but the lack of user involvement in the design of ESM tools hampers clinical implementation. This qualitative study explored the perspective of nine people with lived experiences of psychosis. Participants reported a need to monitor a diverse range of daily-life experiences and indicated that ESM should allow for personalization to be clinically useful. Although participants recognized the potential of ESM to increase awareness and control over their mental health, concerns were voiced about the validity and burden of monitoring one's own mental health.
PSYCHIATRY RESEARCH
(2023)
Editorial Material
Psychology, Clinical
S. Siddi, R. Bailon, I. Gine-Vazquez, F. Matcham, F. Lamers, S. Kontaxis, E. Laporta, E. Garcia, F. Lombardini, P. Annas, M. Hotopf, B. W. J. H. Penninx, A. Ivan, K. M. White, S. Difrancesco, P. Locatelli, J. Aguilo, M. T. Penarrubia-Maria, V. A. Narayan, A. Folarin, D. Leightley, N. Cummins, S. Vairavan, Y. Ranjan, A. Rintala, G. de Girolamo, S. K. Simblett, T. Wykes, I. Myin-Germeys, R. Dobson, J. M. Haro
Summary: This 2-year study examined the intra-individual variations in heart rate (HR) parameters and their relationship with depression severity in individuals with recurrent major depressive disorder. The results showed that decreased HR variation during resting periods during the day was associated with increased depression severity, and higher mean HR during resting at night was observed in participants with more severe depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Zhiling Qiao, Ginette Lafit, Aleksandra Lecei, Robin Achterhof, Olivia J. Kirtley, Anu P. Hiekkaranta, Noemi Hagemann, Karlijn S. F. M. Hermans, Bart Boets, Ulrich Reininghaus, Inez Myin-Germeys, Ruud van Winkel
Summary: This study used a network approach to examine the complex interactions between childhood adversity, psychotic experiences (PEs), other psychiatric symptoms, and multiple psychological mediators. The results revealed the pivotal role of depression, anxiety, negative affect, and loneliness within the network, and the bridging role of threat anticipation between childhood adversity and maladaptive cognitive emotion regulation. Multiple pathways were found between childhood adversity and PEs, with symptoms of general psychopathology as the main connective component. Variables with higher centrality better predicted follow-up PEs.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Thomas Vaessen, Ulrich Reininghaus, Evelyne van Aubel, Annelie Beijer-Klippel, Henrietta Steinhart, Inez Myin-Germeys, James Waltz
Summary: Affective reactivity to daily stressors is increased in individuals in the early stages of psychosis. Studies have shown altered neural reactivity to stress in limbic, prelimbic, and salience areas in psychosis patients and individuals at increased psychosis risk. This study investigates if a similar pattern of neural reactivity is present in early psychosis individuals and if brain activity in these regions is associated with daily-life stress reactivity.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Vivian Shi Cheng Fung, Joseph Ching Yui Chan, Sandra Chi Yiu Wong, Corine Sau Man Wong, Olivia Kirtley, Inez Myin-Germeys, Gregory P. Strauss, Wing Chung Chang
Summary: Negative symptoms in early psychosis are not associated with blunted affective experiences, anhedonia or asociality, according to a study using an experience-sampling methodology. The study found higher intensity and variability of negative affect in patients compared to controls, but no group differences in affect instability or positive affect. Patients also had a preference for company when alone and a preference for being alone when with others. Future research combining experience-sampling methodology with other measures will provide a more refined assessment of negative symptoms in daily life.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Victoria Bell, Eva Velthorst, Jorge Almansa, Inez Myin-Germeys, Sukhi Shergill, Anne-Kathrin Fett
Summary: This study investigates the effects of loneliness and social exclusion on the development of paranoia, and finds that negative affect may mediate the relationship between these factors. The study reveals a significant association between loneliness, social exclusion, and paranoia, and that negative affect partially mediates this association.
SCHIZOPHRENIA RESEARCH-COGNITION
(2023)
Article
Psychology, Multidisciplinary
S. A. Bogemann, A. Riepenhausen, L. M. C. Puhlmann, S. Bar, E. J. C. Hermsen, J. Mituniewicz, Z. C. Reppmann, A. Uscilko, J. M. C. van Leeuwen, C. Wackerhagen, K. S. L. Yuen, M. Zerban, J. Weermeijer, M. A. Marciniak, N. Mor, A. van Kraaij, G. Koeber, S. Pooseh, P. Koval, A. Arias-Vasquez, H. Binder, W. De Raedt, B. Kleim, I. Myin-Germeys, K. Roelofs, J. Timmer, O. Tuescher, T. Hendler, D. Kobylinska, I. M. Veer, R. Kalisch, E. J. Hermans, H. Walter
Summary: This study aims to enhance stress resilience through two new mechanistically targeted just-in-time adaptive interventions, and further advance the field of resilience research by identifying predictors for successful intervention response.
Article
Health Care Sciences & Services
Jeroen Dennis Merlijn Weermeijer, Martien Wampers, Lena de Thurah, Rafael Bonnier, Maarten Piot, Peter Kuppens, Inez Myin-Germeys, Glenn Kiekens
Summary: The experience sampling method (ESM) may facilitate bringing contextual information into therapy, but its implementation in clinical practice is limited. This pilot study evaluates the usability of an ESM protocol in a specialized mental health care setting. Results show that practitioners rated the usability of the ESM protocol as reasonable to good, while clients had slightly lower ratings and voiced concerns over the piloted ESM template.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychology, Applied
Marta Anna Marciniak, Lilly Shanahan, Inez Myin-Germeys, Ilya Milos Veer, Kenneth S. L. Yuen, Harald Binder, Henrik Walter, Erno J. Hermans, Raffael Kalisch, Birgit Kleim
Summary: This study investigated the impact of a mobile health application called Imager on reward sensitivity and mental health symptoms through a two-arm randomized controlled trial. The results showed that participants in the intervention group who used Imager reported fewer mental health symptoms in the follow-up assessment, which may contribute to the clinical preventive practice of affective disorders.
APPLIED PSYCHOLOGY-HEALTH AND WELL BEING
(2023)