Review
Nutrition & Dietetics
Elizabeth A. Miles, Caroline E. Childs, Philip C. Calder
Summary: The immune system is complex and develops in early life, with breast feeding promoting immune maturation and protection against infections and allergies. Long-chain polyunsaturated fatty acids play an important role in immune function, affecting allergic sensitisation and manifestations.
Article
Nutrition & Dietetics
Jerusa da Mota Santana, Marcos Pereira, Gisele Queiroz Carvalho, Maria do Carmo Gouveia Peluzio, Iuri Drumond Louro, Djanilson Barbosa dos Santos, Ana Marlucia Oliveira
Summary: The polymorphisms of fatty acid desaturase genes FADS1 and FADS2 are associated with weight gain, while SNP rs174575 on FADS2 gene has a significant positive direct effect on gestational weight gain. In terms of plasma concentrations of PUFAs, SNP rs174561 and rs174575 have adverse effects on omega-3 fatty acid levels, and SNP rs174575 has positive effects on ARA and ARA/LA ratio, omega-6 products.
Article
Geriatrics & Gerontology
Varinderpal S. Dhillon, Permal Deo, Ann Chua, Phil Thomas, Michael Fenech
Summary: The study investigated the relationship between red blood cell fatty acid status and lymphocyte telomere length (LTL) in 174 healthy older South Australians. Results showed that saturated and monounsaturated fatty acids were negatively associated with LTL, while polyunsaturated fatty acids, particularly arachidonic acid (C20:4n-6), were positively correlated with LTL. Further research is warranted into the significant association of fatty acids, especially C20:4n-6, with telomere length.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Lulu Chang, Haiqin Chen, Xin Tang, Jianxin Zhao, Hao Zhang, Yong Q. Chen, Wei Chen
Summary: Mortierella alpina, an oleaginous filamentous fungus, is used for industrial production of arachidonic acid due to its high lipid productivity. Understanding its metabolic characteristics and key factors governing lipid biosynthesis is essential to enhance its industrial performance. Optimisation of fermentation and metabolic engineering are key strategies to improve lipid yield.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rory J. Heath, Susanna Klevebro, Thomas R. Wood
Summary: The N3 and N6 long chain polyunsaturated fatty acids (LCPUFA) are essential for proper neurodevelopment in early life. This review suggests that feed comprising 0.3% DHA and 0.6% AA may be associated with more positive neurodevelopmental outcomes in premature infants compared to LCPUFA-deplete feed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Melanie Gsoellpointner, Margarita Thanhaeuser, Fabian Eibensteiner, Robin Ristl, Bernd Jilma, Renate Fuiko, Sophia Brandstetter, Angelika Berger, Nadja Haiden
Summary: This study analyzed the intake of polyunsaturated fatty acids (PUFAs) during complementary feeding (CF) in very low birth weight (VLBW) infants and its impact on neurodevelopment. The results showed that higher intake of total PUFAs, docosahexaenoic acid (DHA), and arachidonic acid (AA) was associated with improved cognitive and motor function at 12 months of age. However, the dietary intake of AA and DHA did not meet the recommended levels, highlighting the need to increase PUFA, DHA, and AA intake during CF for better neurodevelopmental outcomes in VLBW infants.
Article
Endocrinology & Metabolism
Kai Wang, Yueyang Zhong, Fangkun Yang, Chenyang Hu, Xin Liu, Yanan Zhu, Ke Yao
Summary: The study found that circulating linoleic acid (LA) accounted for the protective effects of n-6 PUFAs against age-related macular degeneration (AMD), while arachidonic acid (AA) was associated with an increased risk of AMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Kumar S. D. Kothapalli, Hui Gyu Park, Niharika S. L. Kothapalli, J. Thomas Brenna
Summary: Dysregulation of fatty acid metabolism and de novo lipogenesis, specifically related to FADS2, has been found to drive various cancer types through the production of unsaturated fatty acids. The amplification of the 11q13 locus, where FADS2 is localized, is frequently observed in human cancers. FADS2 dysregulation has been associated with the synthesis of different fatty acids and is linked to tumor growth and survival in colorectal and lung cancer patients.
PROGRESS IN LIPID RESEARCH
(2023)
Review
Nutrition & Dietetics
Hans Demmelmair, Berthold Koletzko
Summary: High obesity rates around the world point to an urgent need for effective obesity prevention measures. Animal studies suggest that the effects of essential polyunsaturated fatty acids on adipogenesis may be mediated through various mechanisms. Divergent findings from human clinical trials and observational studies suggest that recommendations for humans regarding PUFA and obesity risk are not yet possible.
Article
Environmental Sciences
Shuangfei Li, Boyu Wang, Liangxu Liu, Yingjie Song, Chuhan Lv, Xingyu Zhu, Yanqing Luo, Christopher H. K. Cheng, Huapu Chen, Xuewei Yang, Tao Li
Summary: The study demonstrates that adding Aurantiochytrium sp. to diets can significantly improve the growth performance and immune response of Trachinotus ovatus. With increased microalgae content, the growth rate and feed utilization efficiency of fish were enhanced, along with increased fatty acid content in blood and tissues, resulting in improved immunity and disease resistance in fish.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Nutrition & Dietetics
Emily Wang, Yeyi Zhu, Rana F. Chehab, Jing Wu, Stefanie N. Hinkle, Natalie L. Weir, Andrew A. Bremer, Jiaxi Yang, Zhen Chen, Michael Y. Tsai, Cuilin Zhang
Summary: The study found that mid-to-late pregnancy is a critical period for fetal growth, with plasma DHA and Delta 5-desaturase activity positively associated with neonatal anthropometric measures.
Article
Microbiology
Heng Zhao, Yong Nie, Yang Jiang, Shi Wang, Tian-Yu Zhang, Xiao-Yong Liu
Summary: This study provides high-quality genome data for two Mortierellaceae fungal species, and compares the genomes of 19 strains from different species. New types of fatty acid synthase enzymes are discovered, and the accumulation of arachidonic acid is found to be associated with specific enzymes. These findings lay the foundation for modulating the yield of polyunsaturated fatty acids.
Article
Biochemistry & Molecular Biology
Naoki Kabeya, Masanari Ogino, Hideki Ushio, Yutaka Haga, Shuichi Satoh, Juan C. Navarro, Oscar Monroig
Summary: This study revealed that Tigriopus californicus, an intertidal harpacticoid copepod, has complete n-3 LC-PUFA biosynthetic pathways, enabling the production of essential fatty acids needed by higher trophic levels.
Review
Biochemistry & Molecular Biology
Hiroshi Kawashima, Katsuhiko Yoshizawa
Summary: Mead acid is a polyunsaturated fatty acid that can be converted to specific lipid mediators and may have effects on inflammation, cancer, dermatitis, and cystic fibrosis. It plays a multifunctional role in various diseases.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Virology
Thor Ueland, Bjorn Waagsbo, Rolf K. Berge, Marius Troseid, Pal Aukrust, Jan K. Damas
Summary: Fatty acids (FAs) play important roles in immune responses and defense mechanisms. Dysregulated metabolism of n-6 polyunsaturated fatty acids (PUFAs) may contribute to HIV infection progression. Patients with advanced HIV disease had lower levels of n-6 PUFA arachidonic acid (AA) and diminished inflammatory cytokine release. Low plasma AA also increased susceptibility to Mycobacterium avium complex (MAC) infection.
Article
Chemistry, Organic
Smita. G. Mane, Kariyappa. S. Katagi, Nikhil. S. Kadam, Mahesh. C. Akki, Shrinivas. D. Joshi
Summary: A series of novel acridine-thiazole bridged coumarin derivatives were synthesized and tested for in-vitro antiproliferative activity on human breast cancer cell lines, with some compounds showing moderate to good activity.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Management
Manu Sharma, Sudhanshu Joshi, Sunil Luthra, Anil Kumar
Summary: This study explores the contribution of Blockchain Technology in managing disruptions caused by COVID-19 and supporting resilient Food Supply Chains. Using a combination of FAHP and WASPAS, the study evaluates factors related to sourcing, lean, workforce, and flexibility, as well as the effectiveness of BC-T enabled resilient strategies in mitigating disruptions during the pandemic. The findings suggest that 'sourcing related' is the most significant disruptive factor in FSCs, and 'flexibility resilient strategy' is the most relevant strategy for BC-T enabled FSCs.
OPERATIONS MANAGEMENT RESEARCH
(2022)
Article
Economics
Sunil Luthra, Manu Sharma, Anil Kumar, Sudhanshu Joshi, Eva Collins, Sachin Mangla
Summary: Economies are transitioning to a circular model to address global issues, and cross-sector collaboration is an effective means to integrate sustainable practices into the value chain. However, the influence of cross-sector collaboration on circular supply chain management is still unexplored, and the barriers and strategies to overcome these barriers need further research.
TRANSPORTATION RESEARCH PART E-LOGISTICS AND TRANSPORTATION REVIEW
(2022)
Article
Metallurgy & Metallurgical Engineering
Suhas Sreekanth, Kjell Hurtig, Shrikant Joshi, Joel Andersson
Summary: This article provides a detailed study on the solution treatments and delta precipitation treatments carried out on laser-directed energy deposited alloy 718 specimens. The research shows that the process parameters greatly influence the delta precipitation, with different microstructural features observed under high and low energy conditions. The morphology and location of the delta phase precipitates studied in this research are crucial for designing the performance of alloy 718 built by DED process.
WELDING IN THE WORLD
(2022)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Rashmi Prava Das, Kamalakanta Muduli, Rakesh Raut, B. E. Narkhede, Himanshu Shee, Abhishek Misra
Summary: This study identifies critical factors to enhance the effectiveness of humanitarian activities during the COVID-19 pandemic. Building a blockchain-enabled digital network and using digital platforms for real-time information sharing are found to be the most significant factors.
Article
Green & Sustainable Science & Technology
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar, Akshat Jain
Summary: The study aims to investigate the impact of green logistics on the adoption of Circular Economy (CE) in the era of Industry 4.0 (I4.0). By implementing green initiatives, the logistics sector shows its strong concern for environmental issues and promotes sustainable logistics and circular practices to address critical issues such as waste generation, resource scarcity, renewable resource use, and climate change. The study examines the relationships between green logistics practices, I4.0 technologies, and CE adoption while also considering the moderating effects of institutional pressure and supply chain flexibility. The findings suggest that firms can enhance CE adoption driven by I4.0 technologies with green logistics practices as a mediator, and the moderating effect of supply chain flexibility is significant while the moderating effect of institutional pressure is insignificant. The study provides valuable insights for managers and contributes to the theoretical understanding of green logistics and CE adoption.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Management
Sudhanshu Joshi, Manu Sharma, Akhilesh Barve
Summary: This study employs the Best Worst Method (BWM) to identify the most critical implementation barriers of IoT and Blockchain technology in Waste Electrical and Electronic Equipment (WEEE) management. The findings reveal that developing a legislative support system, ineffective database management, low understanding of cognitive technologies, and concerns regarding information security and privacy are the key issues in implementing these technologies in closed-loop supply chains.
SUPPLY CHAIN FORUM
(2023)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sudhanshu Joshi, Mukesh Prasad, Shalini Bartwal
Summary: This study proposes a model to examine the critical barriers and suggest strategies for implementing Circular Economy (CE) in the Oil & gas (O&G) industry. The results show that 'knowledge barriers' are the most critical, and the strategies 'Developing collaborative model' and 'Internal research and development, innovation' are the most significant for reducing the barriers.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Banu Y. Ekren, Yigit Kazancoglu, Sunil Luthra, Mukesh Prasad
Summary: Food waste reduction and security are major concerns in agri-food supply chains, as more than a third of global food production is wasted or lost due to mismanagement. Resilient food supply chains need to address challenges such as resource scarcity, climate change, and waste generation. This study explores supply chain innovations, using SWARA analysis, to identify the most significant innovations for developing resilient food supply chains. The results highlight the importance of business strategy and technological innovations in bringing resilience to food supply chains.
Article
Business
Manu Sharma, Deepak Kaushal, Sudhanshu Joshi
Summary: Social media has become a major source of information for young users, but it has a severe impact on mental state due to information overload, which is still a concern for researchers. The addiction of Generation Z users to mobile phones/gadgets is increasing with the rise of social media, leading to a complete transformation in their behavioral outcomes. Behavioral issues such as stress, fatigue, fear of missing out, phubbing, and anxiety are on the rise, but the relationship between these issues and information overload has not been sufficiently examined. The study finds that social media platforms need to understand users' compulsive usage, which results in fatigue and anxiety, and government information support plays a positive role in reducing fatigue and anxiety.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Review
Multidisciplinary Sciences
Sunil Luthra, Shruti Agrawal, Anil Kumar, Manu Sharma, Sudhanshu Joshi, Jatin Kumar
Summary: Psychological and mental well-being of young adults has been greatly influenced by the COVID-19 pandemic, leading to a global concern. This research study provides an overview of the international scientific studies on the effect of COVID-19 on young adults' psychological well-being. It reveals the top-cited authors, documents, journals, productive countries, keywords, and themes in this area. The United States has contributed the most publications, followed by the United Kingdom and Italy. The study highlights the importance of addressing the psychological health of young adults worldwide.
Article
Health Policy & Services
Sudhanshu Joshi, Manu Sharma
Summary: The widespread use of Blockchain technology (BT) in developing nations is still in its early stages and requires a comprehensive evaluation. The healthcare sector is increasingly in need of digitalization to improve operational efficiency. However, the limited research on BT has hindered its full utilization in the healthcare sector. This study aims to identify the main obstacles to BT adoption in developing nations' public health systems, using a multi-level analysis and hybrid approach. The findings of this study provide guidance and insight for decision-makers on implementation challenges.
Article
Management
Manu Sharma, Sudhanshu Joshi
Summary: This study aims to explore the factors that affect the selection of digital suppliers and evaluate the alternatives for identifying the best supplier that enhances the quality management systems (QMS) for digital supply chains (DSCs). The study reveals that supplier competency is the most significant factor in selecting digital suppliers, and supplier S-8 has been ranked as the best supplier.
Article
Business
Sudhanshu Joshi, Rohit Kumar Singh, Manu Sharma
Summary: This study aims to identify the factors influencing the adoption of sustainable agribusiness practices in India and examines the most pertinent issues. The findings can provide guidance for agribusiness regulators and intermediaries, while contributing to a new understanding of sustainable agribusiness-based issues in India.
GLOBAL BUSINESS REVIEW
(2023)
Article
Business
Rohit Kumar Singh, Sudhanshu Joshi, Manu Sharna
GLOBAL BUSINESS REVIEW
(2023)