Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

(2017) Koji Nomura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma

(2017) Gabriel J. Starrett et al.   mBio

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

(2017) Koji Nomura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses

(2017) Hadar Israeli et al.   PLoS Pathogens

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

(2016) Georg Petzold et al.   NATURE

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation

(2016) Christian Berrios et al.   PLoS Pathogens

The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma

(2015) Paul William Harms et al.   CANCER RESEARCH

Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy

(2015) Joan Montero et al.   CELL

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

(2015) Jan Krönke et al.   NATURE

Autoinhibition of MDMX by intramolecular p53 mimicry

(2015) Lihong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)

(2014) L. Saft et al.   HAEMATOLOGICA

Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

(2014) Daqing Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

(2014) Mary Ann Allen et al.   eLife

Mechanisms of p53 Restriction in Merkel Cell Carcinoma Cells Are Independent of the Merkel Cell Polyoma Virus T Antigens

(2013) Roland Houben et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

(2013) Qingjie Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Merkel Cell Polyomavirus Large T Antigen Has Growth-Promoting and Inhibitory Activities

(2013) J. Cheng et al.   JOURNAL OF VIROLOGY

MDMX contains an autoinhibitory sequence element

(2013) M. Bista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abstract 4074: Prostaglandin E2 promotes intestinal tumor growth via DNA methylation

(2012) Dianren Xia et al.   CANCER RESEARCH

Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus

(2012) Scott J. Rodig et al.   JOURNAL OF CLINICAL INVESTIGATION

Survivin Is a Therapeutic Target in Merkel Cell Carcinoma

(2012) R. Arora et al.   Science Translational Medicine

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator

(2011) Masahiro Shuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Imaging the Unfolded Protein Response in Primary Tumors Reveals Microenvironments with Metabolic Variations that Predict Tumor Growth

(2009) M. T. Spiotto et al.   CANCER RESEARCH

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE