Entropic contribution to enhanced thermal stability in the thermostable P450 CYP119

Some Surprising Implications of NMR-directed Simulations of Substrate Recognition and Binding by Cytochrome P450 cam (CYP101A1)

(2018) Eliana K. Asciutto et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural insights into the mechanism of the drastic changes in enzymatic activity of the cytochrome P450 vitamin D3hydroxylase (CYP107BR1) caused by a mutation distant from the active site

(2017) Yoshiaki Yasutake et al.   Acta Crystallographica Section F-Structural Biology Communications

Shedding light on the extra thermal stability of thermophilic proteins

(2016) Andrea Pica et al.   BIOPOLYMERS

Detection of substrate-dependent conformational changes in the P450 fold by nuclear magnetic resonance

(2016) Allison M. Colthart et al.   Scientific Reports

Determination of functional collective motions in a protein at atomic resolution using coherent neutron scattering

(2016) L. Hong et al.   Science Advances

Analysis of Cytochrome P450 CYP119 Ligand-dependent Conformational Dynamics by Two-dimensional NMR and X-ray Crystallography

(2015) Debashree Basudhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

A Fluorescence-Based Thermal Shift Assay Identifies Inhibitors of Mitogen Activated Protein Kinase Kinase 4

(2013) Sankar N. Krishna et al.   PLoS One

The stability ofTaqDNA polymerase results from a reduced entropic folding penalty; identification of other thermophilic proteins with similar folding thermodynamics

(2013) Chin-Chi Liu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Coupled Flexibility Change in Cytochrome P450cam Substrate Binding Determined by Neutron Scattering, NMR, and Molecular Dynamics Simulation

(2012) Yinglong Miao et al.   BIOPHYSICAL JOURNAL

Active-site residues move independently from the rest of the protein in a 200ns molecular dynamics simulation of cytochrome P450 CYP119

(2011) Relly Brandman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A Novel Intermediate in the Reaction of Seleno CYP119 withm-Chloroperbenzoic Acid

(2011) Santhosh Sivaramakrishnan et al.   BIOCHEMISTRY

How Do Thermophilic Proteins and Proteomes Withstand High Temperature?

(2011) Lucas Sawle et al.   BIOPHYSICAL JOURNAL

Cytochrome P450 monooxygenases: an update on perspectives for synthetic application

(2011) Vlada B. Urlacher et al.   TRENDS IN BIOTECHNOLOGY

Conformational Plasticity and Structure/Function Relationships in Cytochromes P450

(2010) Thomas C. Pochapsky et al.   ANTIOXIDANTS & REDOX SIGNALING

P450cam Visits an Open Conformation in the Absence of Substrate,

(2010) Young-Tae Lee et al.   BIOCHEMISTRY

Using Molecular Dynamics To Probe the Structural Basis for Enhanced Stability in Thermal Stable Cytochromes P450

(2010) Yergalem T. Meharenna et al.   BIOCHEMISTRY

Dynamics of Biological Macromolecules: Not a Simple Slaving by Hydration Water

(2010) S. Khodadadi et al.   BIOPHYSICAL JOURNAL

Thermodynamic basis of the thermostability of CYP175A1 from Thermus thermophilus

(2010) Rabindra Kumar Behera et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Altering the regioselectivity of cytochrome P450 BM-3 by saturation mutagenesis for the biosynthesis of indirubin

(2010) Sheng Hu et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Glimpsing the Critical Intermediate in Cytochrome P450 Oxidations

(2010) S. G. Sligar   SCIENCE

Discrimination of thermophilic and mesophilic proteins

(2010) Todd J Taylor et al.   BMC STRUCTURAL BIOLOGY

Crystal Structure and Properties of CYP231A2 from the Thermoacidophilic ArchaeonPicrophilus torridus†,‡

(2008) Winny W. Ho et al.   BIOCHEMISTRY

Protein Dynamics and Stability: The Distribution of Atomic Fluctuations in Thermophilic and Mesophilic Dihydrofolate Reductase Derived Using Elastic Incoherent Neutron Scattering

(2008) Lars Meinhold et al.   BIOPHYSICAL JOURNAL

Exploiting the Link between Protein Rigidity and Thermostability for Data-Driven Protein Engineering

(2008) S. Radestock et al.   ENGINEERING IN LIFE SCIENCES

Ligand-Induced Conformational Heterogeneity of Cytochrome P450 CYP119 Identified by 2D NMR Spectroscopy with the Unnatural Amino Acid13C-p-Methoxyphenylalanine

(2008) Jed N. Lampe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY