Conformational Plasticity and Structure/Function Relationships in Cytochromes P450

Synthetic and Natural Compounds that Interact with Human Cytochrome P450 1A2 and Implications in Drug Development

(2012) B. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Ongoing Challenges in Drug Interaction Safety: from Exposure to Pharmacogenomics

(2010) Jane P.F. Bai   Drug Metabolism and Pharmacokinetics

Structural Basis of Human CYP51 Inhibition by Antifungal Azoles

(2010) Natallia Strushkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

Redox-dependent dynamics of putidaredoxin characterized by amide proton exchange

(2010) Teresa A. Lyons et al.   PROTEIN SCIENCE

Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase

(2009) Natalia Mast et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Steroid and Protein Ligand Binding to Cytochrome P450 46A1 as Assessed by Hydrogen−Deuterium Exchange and Mass Spectrometry

(2009) Wei-Li Liao et al.   BIOCHEMISTRY

Redox-Dependent Dynamics in Cytochrome P450cam

(2009) Susan Sondej Pochapsky et al.   BIOCHEMISTRY

Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1H-imidazole: Ligand-Induced Structural Response through α-Helical Repositioning,

(2009) Sean C. Gay et al.   BIOCHEMISTRY

A Highly Active Single-Mutation Variant of P450BM3(CYP102A1)

(2009) Christopher J. C. Whitehouse et al.   CHEMBIOCHEM

Substrates, Inducers, Inhibitors and Structure-Activity Relationships of Human Cytochrome P450 2C9 and Implications in Drug Development

(2009) S.-F. Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Analysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC fromStreptomyces venezuelae

(2009) Shengying Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating the Structural Plasticity of a Cytochrome P450

(2009) Carmelinda Savino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of Mycobacterium tuberculosis CYP125

(2009) Kirsty J. McLean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 1.5-Å Structure of XplA-heme, an Unusual Cytochrome P450 Heme Domain That Catalyzes Reductive Biotransformation of Royal Demolition Explosive

(2009) Federico Sabbadin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

(2009) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site

(2009) Bin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

13C-Methyl isocyanide as an NMR probe for cytochrome P450 active sites

(2009) Christopher R. McCullough et al.   JOURNAL OF BIOMOLECULAR NMR

Structural and Dynamic Implications of an Effector-induced Backbone Amide cis–trans Isomerization in Cytochrome P450cam

(2009) Eliana K. Asciutto et al.   JOURNAL OF MOLECULAR BIOLOGY

Theoretical and Experimental Studies of the Conversion of Chromopyrrolic Acid to an Antitumor Derivative by Cytochrome P450 StaP: The Catalytic Role of Water Molecules

(2009) Yong Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for androgen specificity and oestrogen synthesis in human aromatase

(2009) Debashis Ghosh et al.   NATURE

Long-lived states to sustain hyperpolarized magnetization

(2009) P. R. Vasos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine

(2009) C. Aldag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

(2009) P. Belin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity

(2009) D. F. V. Lewis et al.   XENOBIOTICA

Improvement of Site of Metabolism Predictions for CYP3A4 by Using Discriminant Analysis of Compound Preference of CYP3A4 X-Ray Structural Conformers and Subsequent Docking

(2009) Peteris Prusis et al.   Quantitative structure-activity relationships & combinatorial science

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

(2009) Chiung-Kuang Chen et al.   PLoS Neglected Tropical Diseases

Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone

(2008) Matthew A. Hummel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Novel haem co-ordination variants of flavocytochrome P450 BM3

(2008) Hazel M. Girvan et al.   BIOCHEMICAL JOURNAL

Crystal Structure of Inhibitor-Bound P450BM-3 Reveals Open Conformation of Substrate Access Channel†,‡

(2008) Donovan C. Haines et al.   BIOCHEMISTRY

Crystal Structure and Properties of CYP231A2 from the Thermoacidophilic ArchaeonPicrophilus torridus†,‡

(2008) Winny W. Ho et al.   BIOCHEMISTRY

Structure-Based Design of a Highly Active Vitamin D Hydroxylase fromStreptomyces griseolusCYP105A1†‡

(2008) Keiko Hayashi et al.   BIOCHEMISTRY

Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1α,25-Dihydroxyvitamin D3†,‡

(2008) Hiroshi Sugimoto et al.   BIOCHEMISTRY

Biocatalysis and substrate chemodiversity: Adaptation of aerobic living organisms to their chemical environment

(2008) Daniel Mansuy   CATALYSIS TODAY

Drugs Behave as Substrates, Inhibitors and Inducers of Human Cytochrome P450 3A4

(2008) Shu-Feng Zhou   CURRENT DRUG METABOLISM

In Silico Prediction of Drug Properties

(2008) M. Hutter   CURRENT MEDICINAL CHEMISTRY

Key Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A Enzymes

(2008) N. M. DeVore et al.   DRUG METABOLISM AND DISPOSITION

Crystal Structures of Cytochrome P450 105P1 from Streptomyces avermitilis: Conformational Flexibility and Histidine Ligation State

(2008) L.-H. Xu et al.   JOURNAL OF BACTERIOLOGY

Determinants of Cytochrome P450 2C8 Substrate Binding

(2008) Guillaume A. Schoch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray Structure of 4,4′-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14α-Demethylase (CYP51)

(2008) Ali Nasser Eddine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Active Site Structure in CYP121

(2008) Kirsty J. McLean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Human Cytochrome P-450 2E1

(2008) Patrick R. Porubsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution NMR Structure of Putidaredoxin–Cytochrome P450cam Complex via a Combined Residual Dipolar Coupling–Spin Labeling Approach Suggests a Role for Trp106 of Putidaredoxin in Complex Formation

(2008) Wei Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Analysis of CYP2R1 in Complex with Vitamin D3

(2008) Natallia Strushkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of CYP199A2, a Para-Substituted Benzoic Acid Oxidizing Cytochrome P450 from Rhodopseudomonas palustris

(2008) Stephen G. Bell et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes

(2008) Dong-Sun Lee et al.   NATURE

Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450BioI ACP complex

(2008) M. J. Cryle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase

(2008) L. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

(2008) N. Mast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Functional Proline Switch in Cytochrome P450cam

(2008) Bo OuYang et al.   STRUCTURE

Hydrogen–deuterium exchange mass spectrometry for investigation of backbone dynamics of oxidized and reduced cytochrome P450cam

(2007) Yoshitomo Hamuro et al.   JOURNAL OF INORGANIC BIOCHEMISTRY