Optimal molecular crowding accelerates group II intron folding and maximizes catalysis

Normal mitochondrial function in Saccharomyces cerevisiae has become dependent on inefficient splicing

(2018) Marina Rudan et al.   eLife

RNA Hairpin Folding in the Crowded Cell

(2016) Mimi Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal ion induced heterogeneity in RNA folding studied by smFRET

(2016) Richard Börner et al.   COORDINATION CHEMISTRY REVIEWS

Cryo-EM structure of the spliceosome immediately after branching

(2016) Wojciech P. Galej et al.   NATURE

Challenge of Mimicking the Influences of the Cellular Environment on RNA Structure by PEG-Induced Macromolecular Crowding

(2015) Jillian Tyrrell et al.   BIOCHEMISTRY

Effects of Cosolvents on the Folding and Catalytic Activities of the Hammerhead Ribozyme

(2015) Shu-ichi Nakano et al.   CHEMBIOCHEM

Mimicking the in vivo Environment – The Effect of Crowding on RNA and Biomacromolecular Folding and Activity

(2015) Erica Fiorini et al.   CHIMIA

Revisiting a dogma: the effect of volume exclusion in molecular crowding

(2015) Anastasia Politou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Effects of Macromolecular Crowding on the Collapse of Biopolymers

(2015) Hongsuk Kang et al.   PHYSICAL REVIEW LETTERS

Protein Folding In Vivo Revisited

(2014) Seong Choi et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Molecular Crowding Accelerates Ribozyme Docking and Catalysis

(2014) Bishnu P. Paudel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of a eukaryotic group II intron lariat

(2014) Aaron R. Robart et al.   NATURE

Molecular crowding overcomes the destabilizing effects of mutations in a bacterial ribozyme

(2014) Hui-Ting Lee et al.   NUCLEIC ACIDS RESEARCH

Molecular-crowding effects on single-molecule RNA folding/unfolding thermodynamics and kinetics

(2014) N. F. Dupuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles of ion recognition in RNA: insights from the group II intron structures

(2014) M. Marcia et al.   RNA

Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds

(2014) Shu-ichi Nakano et al.   FEBS Open Bio

Molecular Crowding Favors Reactivity of a Human Ribozyme Under Physiological Ionic Conditions

(2013) Christopher A. Strulson et al.   BIOCHEMISTRY

Effects of Molecular Crowding on the Structures, Interactions, and Functions of Nucleic Acids

(2013) Shu-ichi Nakano et al.   CHEMICAL REVIEWS

Polymer crowders and protein crowders act similarly on protein folding stability

(2013) Huan-Xiang Zhou   FEBS LETTERS

Influence of crowded cellular environments on protein folding, binding, and oligomerization: Biological consequences and potentials of atomistic modeling

(2013) Huan-Xiang Zhou   FEBS LETTERS

Increased Ribozyme Activity in Crowded Solutions

(2013) Ravi Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crowders Perturb the Entropy of RNA Energy Landscapes to Favor Folding

(2013) Duncan Kilburn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cations in charge: magnesium ions in RNA folding and catalysis

(2012) Jessica C Bowman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hydrostatic and osmotic pressure study of the RNA hydration

(2012) Małgorzata Giel-Pietraszuk et al.   MOLECULAR BIOLOGY REPORTS

Crystal structure of a group II intron in the pre-catalytic state

(2012) Russell T Chan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crowding Promotes the Switch from Hairpin to Pseudoknot Conformation in Human Telomerase RNA

(2011) Natalia A. Denesyuk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of Human Telomeric DNA in Crowded Solution

(2011) Brahim Heddi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The tertiary structure of group II introns: implications for biological function and evolution

(2010) Anna Marie Pyle   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Molecular Crowding Stabilizes Folded RNA Structure by the Excluded Volume Effect

(2010) Duncan Kilburn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-molecule analysis of Mss116-mediated group II intron folding

(2010) Krishanthi S. Karunatilaka et al.   NATURE

Protein folding stability and dynamics imaged in a living cell

(2010) Simon Ebbinghaus et al.   NATURE METHODS

Group II Introns: Mobile Ribozymes that Invade DNA

(2010) A. M. Lambowitz et al.   Cold Spring Harbor Perspectives in Biology

Ca2+ Induces the Formation of Two Distinct Subpopulations of Group II Intron Molecules

(2009) Miriam Steiner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural insights into RNA splicing

(2009) Navtej Toor et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Folding, Stability and Shape of Proteins in Crowded Environments: Experimental and Computational Approaches

(2009) Antonios Samiotakis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Facilitation of RNA Enzyme Activity in the Molecular Crowding Media of Cosolutes

(2009) Shu-ichi Nakano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA folding dynamics by single-molecule fluorescence resonance energy transfer

(2009) Rui Zhao et al.   METHODS

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Molecular crowding effects on structure and stability of DNA

(2008) Daisuke Miyoshi et al.   BIOCHIMIE

Effects of TrimethylamineN-Oxide (TMAO) and Crowding Agents on the Stability of RNA Hairpins

(2008) David L. Pincus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-molecule studies of group II intron ribozymes

(2008) M. Steiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA