Letter
Neurosciences
Shitao Lv, Haiyan Yang, Pengcheng Jing, Haiying Song
Summary: Alpha-tocopherol has shown antioxidant, anti-inflammatory, and anti-apoptotic abilities in rat brain tissue, mitigating nerve damage caused by cerebral ischemia-reperfusion injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Gaizka Gutierrez-Sanchez, Ignacio Garcia-Alonso, Jorge Gutierrez Saenz de Santa Maria, Ana Alonso-Varona, Borja Herrero de la Parte
Summary: The study found that nitroindazole has a preventive/protective effect against intestinal tissue damage in the early stages of intestinal ischemia-reperfusion injury (i-IRI), reducing the extent of damage, and showing significant effects in both 1 and 2-hour ischemia periods. More research is needed to better understand the molecular mechanisms underlying this phenomenon.
Article
Medicine, General & Internal
Jinghao Wang, Kai Fan, Cong He, Qingyang Wang, Qianhui Zhang, Wei Huang
Summary: A new Danshensu/tetramethylpyrazine derivative (ADTM) shows cardio-protection effects by inhibiting PAFR signaling to protect against MIR injury, with antioxidant, arterial relaxation, pro-angiogenesis, and antiplatelet activities.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Carlos Andres Pantanali, Vinicius Rocha-Santos, Marcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D'Albuquerque, Flavio Henrique Galvao
Summary: Nutraceuticals are bioactive compounds found in food that can improve health, prevent diseases, and support the normal functioning of the human body. They are able to target multiple pathways, acting as antioxidants, anti-inflammatory agents, and immune response and cell death modulators. This study investigated the effect of a nutraceutical solution on liver ischemia-reperfusion injury (IRI), and found that it decreased apoptosis and histologic injury in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wei-wei Li, Dan Li, Yao Qin, Cheng-xin Sun, Yong-ling Wang, Lei Gao, Lang Ling-Hu, Feng Zhang, Wen Cai, Lei Zhu, Gang Wang
Summary: The study demonstrated that AME has significant protective effects against myocardial ischemia-reperfusion injury by reducing inflammation levels and cell apoptosis rate. The therapeutic potential of AME for managing myocardial ischemia-reperfusion injury is highlighted in this study.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yuanyuan Wu, Zinah D. Zwaini, Nigel J. Brunskill, Xinyue Zhang, Hui Wang, Ravinder Chana, Cordula M. Stover, Bin Yang
Summary: The study showed that mice lacking Properdin exhibited more severe renal injury during the repair phase post IR, with Properdin playing a crucial role in optimizing damaged cells and regulating phagocytic ability to effectively clear apoptotic cells and reduce inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Shen-ping Tang, Xin-li Mao, Ya-hong Chen, Ling-ling Yan, Li-ping Ye, Shao-wei Li
Summary: Liver transplantation is the ultimate method for treating end-stage liver disease. The increasing prevalence of obesity and non-alcoholic fatty liver has led to a rise in the number of patients who may require liver transplantation. Ischemia-reperfusion injury and oxidative stress play key roles in the pathogenesis of non-alcoholic fatty liver and its sensitivity to transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qihong Wu, Rong Xu, Kun Zhang, Ran Sun, Mengxi Yang, Kuan Li, Hanrui Liu, Yiyuan Xue, Huayan Xu, Yingkun Guo
Summary: This study comprehensively characterized the physiopathologic changes of myocardial injury after ischemia-reperfusion. It found that the early stage of reperfusion injury is mainly characterized by edema rather than inflammation, and suggested that edema may be a crucial factor contributing to myocardial injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Maged E. Mohamed, Nancy S. Younis
Summary: The study found that pretreatment with D-carvone can protect the liver against damage induced by hepatic ischemia-reperfusion. D-carvone downregulates the expression of HMGB1, TLR4, NF kappa B, and NLP3, leading to a reduction in adhesion molecules, neutrophil infiltration, inflammatory mediators, and apoptotic markers.
Article
Pharmacology & Pharmacy
Boyu Xia, Qi Li, Jingjing Wu, Xiaomei Yuan, Fei Wang, Xu Lu, Chao Huang, Koulong Zheng, Rongrong Yang, Le Yin, Kun Liu, Qingsheng You
Summary: Sinomenine has cardioprotective effects in a mouse model of myocardial ischemia-reperfusion injury by attenuating oxidative stress, inflammation, and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoli Min, Linping Zhao, Ying Shi, Jian Wang, Hongling Lv, Xiaoxiao Song, Qunyuan Zhao, Qing Zhao, Rui Jing, Jiayi Hu
Summary: This study investigates the role of Gomisin J in cerebral ischemia-reperfusion injury and finds that it has anti-apoptotic, antioxidant, and anti-inflammatory effects, reducing the severity of the injury.
Article
Medicine, Research & Experimental
Eman M. Embaby, Rasha M. Saleh, Basma H. Marghani, Nashwa Barakat, Walaa Awadin, Mohamed F. Elshal, Islam S. Ali, Nabil Abu-Heakal
Summary: The study aimed to investigate the efficacy of zinc oxide nanoparticles (ZnO-NPs) and/or milrinone (MIL) on renal ischemia/reperfusion injury (I/RI) in rats and their possible underlying mechanisms. The administration of ZnO-NPs or MIL significantly decreased serum creatinine and urea concentrations, renal vascular permeability, oxidative stress, and the expression of inflammatory markers. Combination treatment of ZnO-NPs and MIL showed a synergistic effect, providing even better renoprotective effects.
Article
Pharmacology & Pharmacy
Qi Li, Boyu Xia, Jingjing Wu, Xiaomei Yuan, Xu Lu, Chao Huang, Hongcheng Gu, Koulong Zheng, Qingsheng You, Kun Liu
Summary: The study demonstrates that administration of indole-3-carbinol (I3C) protects the heart from myocardial ischemia/reperfusion injury (MIRI) through its anti-apoptotic, antioxidant, and anti-inflammatory effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Meng Sun, Rong Wang, Rui Xia, Zhengyuan Xia, Zhilin Wu, Tingting Wang
Summary: Mechanisms contributing to myocardial ischemia-reperfusion (I/R) injury are complex, but Dexmedetomidine (DEX) shows potential in ameliorating this injury in diabetic states. DEX activates the PI3K/Akt and associated GSK-3 beta pathway, alleviates endoplasmic reticulum stress, and inhibits apoptosis. Additionally, DEX up-regulates autophagy, reduces ROS production, and inhibits inflammation via HMGB1 pathways, leading to the protection against diabetic myocardial I/R injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anesthesiology
Yi-Nan Zhang, Ze-Nan Chang, Zi-Meng Liu, Shi-Hong Wen, Ya-Qing Zhan, Han-Jin Lai, Hu-Fei Zhang, Yi Guo, Xu-Yu Zhang
Summary: Intestinal ischemia/reperfusion (I/R) challenge leads to gut barrier dysfunction and distant organ injury. Dexmedetomidine can protect against this damage and minimize gut-vascular barrier (GVB) and liver injuries in mice.
ANESTHESIA AND ANALGESIA
(2022)
