Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose

Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress

(2018) Alec G. Trub et al.   TRENDS IN BIOCHEMICAL SCIENCES

Simultaneous Quantification of the Acetylome and Succinylome by ‘One-Pot’ Affinity Enrichment

(2018) Nathan Basisty et al.   PROTEOMICS

Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels

(2017) Alessandro Carrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

(2017) Samir Softic et al.   JOURNAL OF CLINICAL INVESTIGATION

Accurate Quantification of Site-specific Acetylation Stoichiometry Reveals the Impact of Sirtuin Deacetylase CobB on theE. coliAcetylome

(2017) Brian Tate Weinert et al.   MOLECULAR & CELLULAR PROTEOMICS

PIQED: automated identification and quantification of protein modifications from DIA-MS data

(2017) Jesse G Meyer et al.   NATURE METHODS

Hawkmoths use nectar sugar to reduce oxidative damage from flight

(2017) E. Levin et al.   SCIENCE

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

(2017) Ben C. Collins et al.   Nature Communications

Site-specific identification and quantitation of endogenous SUMO modifications under native conditions

(2017) Ryan J. Lumpkin et al.   Nature Communications

Non-enzymatic N -acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S -acetylated Thiol Intermediate Sensitive to Glyoxalase II

(2017) Andrew M. James et al.   Cell Reports

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

(2017) Daniel Mauvoisin et al.   Cell Reports

Proteome-wide acetylation dynamics in human cells

(2017) Yekaterina Kori et al.   Scientific Reports

The Substrate Specificity of Sirtuins

(2016) Poonam Bheda et al.   Annual Review of Biochemistry

Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH)

(2016) Jesse G. Meyer et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome

(2016) Siegfried Ussar et al.   Molecular Metabolism

Site-Specific Reactivity of Nonenzymatic Lysine Acetylation

(2015) Josue Baeza et al.   ACS Chemical Biology

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

(2015) Siegfried Ussar et al.   Cell Metabolism

Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

(2015) B. T. Weinert et al.   EMBO JOURNAL

mapDIA: Preprocessing and statistical analysis of quantitative proteomics data from data independent acquisition mass spectrometry

(2015) Guoshou Teo et al.   Journal of Proteomics

Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues

(2015) Roland Bruderer et al.   MOLECULAR & CELLULAR PROTEOMICS

NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance

(2015) Feng Li et al.   MOLECULAR CELL

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Protein acetylation dynamics in response to carbon overflow inEscherichia coli

(2015) Birgit Schilling et al.   MOLECULAR MICROBIOLOGY

DIA-Umpire: comprehensive computational framework for data-independent acquisition proteomics

(2015) Chih-Chiang Tsou et al.   NATURE METHODS

Trans-Proteomic Pipeline, a standardized data processing pipeline for large-scale reproducible proteomics informatics

(2015) Eric W. Deutsch et al.   Proteomics Clinical Applications

Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling

(2014) Osama Abo Alrob et al.   CARDIOVASCULAR RESEARCH

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

(2014) Deborah M. Muoio   CELL

Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation

(2014) Olga Pougovkina et al.   HUMAN MOLECULAR GENETICS

Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

(2014) Gregory R. Wagner et al.   MOLECULAR CELL

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: Chemical and metabolic logic of acetyl-lysine modifications

(2013) Sirisha Ghanta et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Elevated citrate levels in non-alcoholic fatty liver disease: The potential of citrate to promote radical production

(2013) Bregje van de Wier et al.   FEBS LETTERS

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

(2013) Sivakama S. Bharathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

(2012) Ludovic C. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue

(2012) Ulrika S. Pettersson et al.   PLoS One

Proteomic Investigations of Lysine Acetylation Identify Diverse Substrates of Mitochondrial Deacetylase Sirt3

(2012) Eri Maria Sol et al.   PLoS One

Drug metabolism alterations in nonalcoholic fatty liver disease

(2011) Matthew D. Merrell et al.   DRUG METABOLISM REVIEWS

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

(2010) Julien Bricambert et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Calorie restriction alters mitochondrial protein acetylation

(2009) Bjoern Schwer et al.   AGING CELL

The Randle cycle revisited: a new head for an old hat

(2009) Louis Hue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Metabolic flexibility and insulin resistance

(2008) Jose E. Galgani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ethanol intoxication increases hepatic N-lysyl protein acetylation

(2008) Matthew J. Picklo   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS