Article
Immunology
Miao-Hsi Hsieh, Pei-Chi Chen, Han-Yin Hsu, Jui-Chang Liu, Yu-Sheng Ho, Yuh Jyh Lin, Chin-Wei Kuo, Wen-Shuo Kuo, Hui-Fang Kao, Shulhn-Der Wang, Zhi-Gang Liu, Lawrence Shih-Hsin Wu, Jiu-Yao Wang
Summary: Increased levels of SP-D and FMs are found in oxidative stress conditions and/or COPD patients. Our study reveals the crucial roles of SP-D in airway inflammation and emphysematous changes, and shows that rfhSP-D can reverse these changes.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Taruna Madan, Barnali Biswas, Praveen M. Varghese, Rambhadur Subedi, Hrishikesh Pandit, Susan Idicula-Thomas, Indra Kundu, Sheetalnath Rooge, Reshu Agarwal, Dinesh M. Tripathi, Savneet Kaur, Ekta Gupta, Sanjeev K. Gupta, Uday Kishore
Summary: The recombinant fragment of human SP-D (rfhSP-D) significantly reduced SARS-CoV-2 infection and replication by interacting with the spike protein and human ACE-2 receptor.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Microbiology
Emily J. Strong, Jia Wang, Tony W. Ng, Steven A. Porcelli, Sunhee Lee
Summary: Tuberculosis is a significant global infectious disease caused by Mycobacterium tuberculosis infection of the lungs. The PPE51 protein of Mtb inhibits autophagy by suppressing TLR2 signaling, allowing the bacteria to evade immune responses.
Article
Biochemistry & Molecular Biology
Sang-Hun Kim, Hyeon Jun Shin, Chang Min Yoon, Sei Won Lee, Lokesh Sharma, Charles S. Dela Cruz, Min-Jong Kang
Summary: The study identified a novel role of PINK1 in regulating MAVS signaling, where PINK1 interacts with and stabilizes MAVS, inhibiting its multimeric aggregation. PINK1 deficiency enhances MAVS-mediated antiviral innate immune and NLRP3 inflammasome signaling, affecting pulmonary pathobiology in response to viral infection and fibrotic injury.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Immunology
Qiqi Wang, Qiong Wang, Ziyue Zhao, Jingbo Fan, Linghan Qin, David B. Alexander, Hiroyuki Tsuda, Dahai Zhao, Jiegou Xu
Summary: Alveolar macrophages are responsible for clearing airborne dust and pathogens. The study found that surfactant proteins can enhance phagocytosis of various nanomaterials by alveolar macrophages, and increase cytokine production. Surfactant proteins opsonize nanomaterials through the CD14 receptor, serving as a common pathway for their phagocytosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yun Lu, Xiangyu Li, Kai Zhao, Yuanxin Shi, Zhengdong Deng, Wei Yao, Jianming Wang
Summary: This study identified novel protein kinases associated with cholangiocarcinoma (CCA) and demonstrated the effectiveness of the pan-inhibitor of the PKD family, 1-naphthyl PP1 (1-NA-PP1), in inhibiting the proliferation, migration, and invasion ability of CCA cells. These findings provide new therapeutic targets for CCA.
Article
Biochemistry & Molecular Biology
Izumi Matsuba, Rikako Fujita, Kaoruko Iida
Summary: In this study, the effect of palmitic acid (PA), the most common fatty acid component in human fat, on muscle fiber type was assessed, focusing on the expression of fiber-type-specific myosin heavy chain (MHC). The study found that PA selectively suppresses the mRNA and protein expression of fast-twitch MHC, potentially providing a pathogenic mechanism for age-related sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Xue-feng Shi, Xiang He, Ze-rui Sun, Jian-xiang Wang, Yu-hai Gu, You-bang Xie, Jie Duo
Summary: This study identifies distinct miRNA signatures in Tibetan COPD patients that could be used as diagnostic biomarkers or describe differential molecular mechanisms. Functional analysis of the target genes of differentially expressed miRNAs showed their influence on cell morphogenesis and signaling pathways. Age, plasma miRNA, and SP-D mRNA expression were found to be correlated with COPD risk factors.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Chao Chen, Zhenxing Zhang, Caiyun Liu, Bin Wang, Ping Liu, Shu Fang, Fan Yang, Yongping You, Xinjian Li
Summary: Excessive consumption of fructose contributes to cancer development. This study reveals that glucose deprivation induces fructolysis in glioblastoma cells, which is mediated by ATF4. Inhibition of ATF4-dependent fructolysis significantly suppresses growth and colony formation of glioblastoma cells in vitro and in vivo.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Xiao-Li Yang, Yu-Shui Ma, Yu-Shan Liu, Xiao-Hui Jiang, Hua Ding, Yi Shi, Cheng-You Jia, Gai-Xia Lu, Dan-Dan Zhang, Hui-Min Wang, Pei-Yao Wang, Zhong-Wei Lv, Fei Yu, Ji-Bin Liu, Da Fu
Summary: miR-873 can suppress the self-renewal and proliferation of pancreatic cancer stem cells by blocking PLEK2-dependent PI3K/AKT pathway. This study contributes to understanding the role of miR-873 in pancreatic cancer stem cells and its underlying molecular mechanisms to aid in the development of effective pancreatic cancer therapeutics.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Guan-Man Li, Lei Li, Meng-Qing Li, Xu Chen, Qiao Su, Zhi-Juan Deng, Hai-Bo Liu, Bin Li, Wen-Hui Zhang, Yong-Xu Jia, Wen-Jian Wang, Jie-Yi Ma, Hai-Liang Zhang, Dan Xie, Xiao-Feng Zhu, Yu-Long He, Xin-Yuan Guan, Jiong Bi
Summary: The study demonstrates that tumor-suppressive function of DAPK3 is dependent on autophagy process through direct phosphorylation of ULK1 at Ser556, enhancing ULK1 complex formation and VPS34 complex activation. Clinical samples also show that coordinated expression of DAPK3 with ULK1 Ser556 phosphorylation is associated with favorable survival outcomes in gastric cancer patients. This suggests that DAPK3 may serve as a promising prognostic autophagy-associated marker in gastric cancer.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Medical Laboratory Technology
Lucia Salvioni, Filippo Testa, Adela Sulejmani, Francesca Pepe, Pietro Giorgio Lovaglio, Paolo Berta, Roberto Dominici, Valerio Leoni, Davide Prosperi, Giorgio Vittadini, Miriam Colombo, Luisa Fiandra
Summary: SP-D can serve as a predictive biomarker for COVID-19 disease and its outcome. Elevated plasma levels of SP-D are associated with disease severity and mortality. Monitoring SP-D levels in hospitalized patients can guide therapeutic interventions.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Siming Zhang, Qifeng Tu, Xiaowei Qian, Junpei Wang, Chao Ma, Liu Yang, Yan Liu, Ronghua Wu, Mei Liu
Summary: In this study, the knockout of the Kif15 gene was found to significantly inhibit tumor growth, and this inhibition was related to the activation of the immune system.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Raquel Arroyo, Shawn N. Grant, Miriam Colombo, Lucia Salvioni, Fabio Corsi, Marta Truffi, Davide Ottolina, Brett Hurst, Marc Salzberg, Davide Prosperi, Paul S. Kingma
Summary: SARS-CoV-2 infection of host cells is driven by the binding of the virus spike protein to lung cells, and the study aims to measure pulmonary SP-D levels in COVID-19 patients and demonstrate its activity against the virus. Results show that SP-D can bind to the SARS-CoV-2 spike protein, initiate aggregation, and inhibit viral replication in cells.
Article
Biochemistry & Molecular Biology
Taisuke Tomonaga, Hiroto Izumi, Yukiko Yoshiura, Chinatsu Nishida, Kazuhiro Yatera, Yasuo Morimoto
Summary: The study found that there are different levels of lung toxicity between high-toxicity and low-toxicity nanomaterials, as well as differences in the expression levels of SP-D in lung tissue and in the body. SP-D in BALF and serum can serve as biomarkers for evaluating pulmonary toxicity of nanomaterials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
David Schneberger, Jane M. DeVasure, Kristina L. Bailey, Debra J. Romberger, Todd A. Wyatt
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2017)
Article
Toxicology
Deepak Chandra, Jill A. Poole, Kristina L. Bailey, Elizabeth Staab, Jenea M. Sweeter, Jane M. DeVasure, Debra J. Romberger, Todd A. Wyatt
INHALATION TOXICOLOGY
(2018)
Article
Substance Abuse
Kristina L. Bailey, Harry Smith, Susan K. Mathai, Jonathan Huber, Mark Yacoub, Ivana Yang, Todd A. Wyatt, Katerina Kechris, Ellen L. Burnham
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Environmental Sciences
Upkardeep Pandher, Shelley Kirychuk, David Schneberger, Brooke Thompson, Gurpreet Aulakh, R. S. Sethi, Baljit Singh
Summary: The combined exposure of LPS and glyphosate resulted in more severe inflammatory responses in the respiratory system of mice compared to individual exposure, but the inflammation decreased after 10 days, with leukocyte infiltration persisting. Glyphosate exposure modified LPS-induced inflammatory responses, and TLR-2 might play a crucial role in modulating the inflammatory response.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Immunology
Sannette C. Hall, Deandra R. Smith, Shetty Ravi Dyavar, Todd A. Wyatt, Derrick R. Samuelson, Kristina L. Bailey, Daren L. Knoell
Summary: Zinc is essential for immune function and host defense, regulated by zinc transporters. Zinc deficiency can increase susceptibility to bacterial infections, especially Streptococcus pneumoniae. Myeloid cells, such as macrophages and dendritic cells, play a critical role in shaping the immune response in the lung against bacterial pathogens.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Pathology
Todd A. Wyatt, Kristi J. Warren, Tanner J. Wetzel, Troy Suwondo, Gage P. Rensch, Jane M. DeVasure, Deanna D. Mosley, Kusum K. Kharbanda, Geoffrey M. Thiele, Ellen L. Burnham, Kristina L. Bailey, Samantha M. Yeligar
Summary: Alcohol misuse and smoking can lead to decreased levels of secretory IgA (sIgA) and increased levels of Transforming growth factor-beta (TGF-beta) in the lungs, potentially impacting the immune response against pneumonia. Experiments showed that MAA-adducted surfactant protein can stimulate lung epithelial cells to release TGF-beta, decreasing pIgR and sIgA transcytosis. This provides a potential mechanism for the observed decrease in sIgA levels in smokers who misuse alcohol.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Substance Abuse
Kristina L. Bailey, Harlan Sayles, James Campbell, Neha Khalid, Madyson Anglim, Jana Ponce, Todd A. Wyatt, James C. McClay, Ellen L. Burnham, Alfred Anzalone, Corrine Hanson
Summary: This study reveals that alcohol use disorder (AUD) may increase the severity and mortality of COVID-19 infection. This emphasizes the importance for clinicians to obtain accurate alcohol history from patients hospitalized with COVID-19.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Substance Abuse
Abenaya Muralidharan, Christopher Bauer, Dawn M. Katafiasz, Danielle Pham, Opeoluwa O. Oyewole, M. Jane Morwitzer, Enakshi Roy, Kristina L. Bailey, St Patrick Reid, Todd A. Wyatt
Summary: This study investigates the possible mechanism underlying the severity and mortality of SARS-CoV-2 infection in patients who misuse alcohol. The research reveals that alcohol overconsumption can lead to oxidative damage in the lungs, causing the adduction of SPD protein with acetaldehyde. This impairs the ability of SPD to bind with the spike protein of SARS-CoV-2, weakening its neutralizing effect on the virus.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Toxicology
Amber. N. N. Johnson, John Dickinson, Amy Nelson, Rohit Gaurav, Katrina Kudrna, Scott. E. E. Evans, Katherine Janike, Todd. A. A. Wyatt, Jill. A. A. Poole
Summary: The Toll-like receptor (TLR) adaptor protein MyD88 plays an important role in airway inflammatory response. Experiments show that deficiency in MyD88 inhibits airway neutrophil influx and release of pro-inflammatory cytokines induced by organic dust exposure, but increases airway epithelial cell mucin expression. MyD88-dependent signaling in specific lung airway epithelial cells is crucial in mediating neutrophil influx and mucin production in response to acute organic dust exposures.
JOURNAL OF IMMUNOTOXICOLOGY
(2023)
Article
Pathology
Divya T. Chemparathy, Susmita Sil, Shannon Callen, Hitendra S. Chand, Mohan Sopori, Todd A. Wyatt, Arpan Acharya, Siddappa N. Byrareddy, Howard S. Fox, Shilpa Buch
Summary: This study investigated the progression of lung tissue remodeling in a rhesus macaque model of SIV infection with morphine exposure. The results showed that SIV independently induced fibrotic changes in the lungs, which were further aggravated by morphine.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Toxicology
T. A. Wyatt, M. Nemecek, D. Chandra, J. M. DeVasure, A. J. Nelson, D. J. Romberger, J. A. Poole
JOURNAL OF IMMUNOTOXICOLOGY
(2020)
Article
Substance Abuse
Muna Sapkota, Ellen L. Burnham, Jane M. DeVasure, Jenea M. Sweeter, Carlos D. Hunter, Michael J. Duryee, Lynell W. Klassen, Kusum K. Kharbanda, Joseph H. Sisson, Geoffrey M. Thiele, Todd A. Wyatt
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2017)
Review
Cell Biology
Ram S. Sethi, David Schneberger, Chandrashekhar Charavaryamath, Baljit Singh
CELL AND TISSUE RESEARCH
(2017)