Article
Biochemistry & Molecular Biology
Chien-Yu Huang, Po-Li Wei, Uyanga Batzorig, Precious Takondwa Makondi, Cheng-Chin Lee, Yu-Jia Chang
Summary: CRC is the second leading cause of cancer-related death, and identifying new therapeutic targets for CRC is essential. This study investigated the role of MSN in CRC progression and found that high MSN expression in CRC tissues was associated with poor patient outcomes. Further research revealed that MSN accelerated CRC progression via the beta-catenin-RUNX2 axis. These findings suggest that MSN holds potential as a new target for CRC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Young Yun Jung, Jae-Young Um, Arunachalam Chinnathambi, Chandramohan Govindasamy, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of Withaferin A (WFA) on apoptosis and autophagy in human colorectal cancer cells. The results showed that WFA could induce cell cycle arrest, increase apoptotic cell death, and activate autophagy. The WFA-induced effects on apoptosis and autophagy were mediated through the modulation of the beta-catenin pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Zhiyu Ji, Aoning Mi, Mengmeng Li, Quanying Li, Changjiang Qin
Summary: The study revealed that high expression of KIF23 is associated with the malignancy and prognosis of CRC, and its knockdown can inhibit cell proliferation, migration, and invasion. Mechanistic studies showed that KIF23 regulates the malignant behavior of CRC cells by activating the Wnt/beta-catenin signaling pathway.
Article
Oncology
Hongyan Li, Ning Zhang, Xueli Jiao, Cong Wang, Wenhao Sun, Yanyu He, Ganglin Ren, Shirui Huang, Mengjie Li, Yixin Chang, Zihui Jin, Qipeng Xie, Xiaodong Zhang, Haishan Huang, Honglei Jin
Summary: MiR-6125 is downregulated in CRC, negatively correlated with tumor size and prognosis. MiR-6125 targets YTHDF2, downregulates its protein, stabilizes m6A-modified GSK3 beta mRNA. Increased GSK3 beta protein inhibits Wnt/beta-catenin/Cyclin D1 pathway proteins, leading to G0-G1 phase arrest and inhibiting CRC cell proliferation.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
XiaoJuan Xie, HuiJin Li, JingJing Pan, Xi Han
Summary: TRIM26 is upregulated in bladder cancer tissues and its absence inhibits cellular behaviors, while overexpression promotes cell proliferation, migration and invasion. TRIM26 regulates cell proliferation, migration, and invasion in bladder cancer through the Akt/GSK3 beta/beta-catenin pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant
Summary: The incidence of early-onset colorectal cancer (EO-CRC) is rising, with lifestyle factors and genetic background playing a potential role. The study found a missense mutation, HNF1AA98V, in the Hepatic Nuclear Factor 1α (HNF1A) gene, which reduces DNA binding ability. In mice, introducing the HNF1AA98V variant and feeding a high-fat or high-sugar diet led to an increased formation of colonic polyps. The study also revealed alterations in gene expression and signaling pathways related to metabolism, immunity, and lipid biogenesis.
Article
Oncology
Xinyu Jiang, Wenfei Du, Chenglong Yang, Shuying Wang, Yifei Li, Xinzhuang Shen, Xiaowen Yang, Jie Yao, Renle Du, Xiaoyuan Zhang, Yongming Huang, Wenzhi Shen
Summary: This study found that the expression of TBX21 is significantly decreased in colorectal cancer and negatively correlated with tumor stages. Ectopic expression of TBX21 inhibits cell proliferation and promotes apoptosis. Furthermore, TBX21 inhibits colorectal tumor progression through the ARHGAP29/RSK/GSK3 beta signaling pathway.
Article
Biochemistry & Molecular Biology
Siyang Chen, Hui Ding, Kaiyun Wang, Kaiwen Guo
Summary: This study found that Wnt7b is highly expressed in colorectal cancer cells and may affect the proliferation, migration, and invasion of colorectal cancer cells by activating the Wnt/beta-catenin signaling pathway.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Multidisciplinary Sciences
Yanlin Chen, Liping Yang, Yilu Qin, Shuiqing Liu, Yina Qiao, Xueying Wan, Huan Zeng, Xiaoli Tang, Manran Liu, Yixuan Hou
Summary: The study revealed that the cellular localization of JUP in gastric cancer is closely related to tumor progression and invasion, with a loss of membrane and/or cytoplasmic JUP exacerbating the malignancy, while the nuclear function of JUP in cooperation with B-catenin promotes gastric cancer cell invasion.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cell Biology
Yan Sun, Lin Wang, Xuehu Xu, Puqing Han, Jinghao Wu, Xuan Tian, Mingsong Li
Summary: The study demonstrated that downregulated FOXO4 in CRC tissues inhibits migration and metastasis of CRC cells by upregulating APC2 expression and enhancing beta-catenin degradation. Overexpressed FOXO4 suppressed the expression of stemness genes, epithelial-mesenchymal transition, migration of CRC cell lines, and metastasis in nude mice, which was reversed by APC2 knockdown.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yuanzhe Zhu, Huala Wu, Xi Yang, Zhijuan Xiong, Tiantian Zhao, Xin Gan
Summary: This study revealed that LINC00514 is upregulated in NSCLC and plays a role in the proliferation, migration, and invasion of NSCLC cells through activation of the Wnt/β-catenin pathway and EMT. Silencing LINC00514 restored the biological phenotypes of NSCLC cells by inhibiting the Wnt/β-catenin pathway. Additionally, silencing LINC00514 attenuated the growth of xenograft tumors in vivo.
Article
Oncology
Himanshu Singh Saroha, Rohith Kumar Guddeti, Jasmine P. Jacob, Kiran Kumar Pulukuri, Prashanthi Karyala, Suresh B. Pakala
Summary: The expression of MORC2 is positively correlated with beta-catenin in breast cancer, and overexpression of MORC2 increases beta-catenin and its target genes. The target gene of beta-catenin, c-Myc, regulates the MORC2-beta-catenin signaling axis through a feedback mechanism. MORC2 regulates beta-catenin expression and function by modulating AKT phosphorylation, promoting proliferation and migration of breast cancer cells.
Review
Chemistry, Medicinal
Manjinder Singh Phull, Surender Singh Jadav, Rambabu Gundla, Prathama S. Mainkar
Summary: Colorectal cancer is a major cause of carcinogenic mortality, with mutations in the APC gene playing a key role. Current research is focused on developing new anti-colorectal cancer drugs by targeting essential cellular components.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Li Gao, Ying Lu, Hai-Ning Chen, Zhigui Li, Meng Hu, Rou Zhang, Xiuxuan Wang, Zhiqiang Xu, Yanqiu Gong, Rui Wang, Dan Du, Shan Hai, Shuangqing Li, Dan Su, Yuan Li, Heng Xu, Zong-Guang Zhou, Lunzhi Dai
Summary: This study found that the expression of GSK3 alpha, but not GSK30, was significantly correlated with the overall survival of colon cancer patients. Through analysis of its phosphorylation substrates and protein interactions, specific functions of GSK3 alpha in colon cancer were revealed, suggesting it as a potential therapeutic target.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Dermatology
Kyung-Il Kim, Kyung Eun Jung, Young-Bin Shin, Chang-Deok Kim, Tae-Jin Yoon
Summary: In this study, we conducted a large-scale screening test on drugs approved for other diseases to find pigmentation-modulating agents. Among the potential drugs, sorafenib was selected for further investigation on its effect on pigmentation in melanoma cells. The results showed that sorafenib promoted pigmentation by increasing the melanin content and tyrosinase activity. Mechanistic studies revealed that this effect was mediated by the activation of beta-catenin signaling through the regulation of GSK3 beta phosphorylation.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.