Article
Physiology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: The study reveals that Qishen Yiqi dripping pill exerts renal-protective function by inhibiting the Wnt/beta-catenin and TGF-beta/Smad2 signaling pathways in diabetic rats, as evidenced by reduced levels of serum markers and improved kidney histology and fibrosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Yuewen Tang, Feng Wan, Xuanli Tang, Yi Lin, Huaqin Zhang, Jiawei Cao, Ruchun Yang
Summary: Proteinuria is a risk factor for the progression of diabetic nephropathy and an imbalance in podocyte function exacerbates proteinuria. Celastrol, the active ingredient of T. wilfordii, has been effective in treating renal injury in diabetic nephropathy, but its mechanisms are unclear. This study investigated how celastrol prevents podocyte damage in diabetic nephropathy using in vivo and in vitro experiments. Celastrol reduced blood glucose levels, attenuated renal histomorphological injury, and induced anti-inflammatory effects. It upregulated SIRT1 expression and downregulated EZH2, inhibiting the wnt/beta-catenin pathway. SIRT1 repression aggravated podocyte injury, while celastrol protected podocyte injury via SIRT1/EZH2 in the wnt/beta-catenin pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Microbiology
Zhiyu Liu, Xiaoyan Liu
Summary: Research has shown that there is a relationship between alopecia areata and the gut microbiome or metabolome, providing new directions for the prevention, clinical diagnosis, and treatment of this condition.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Cell Biology
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Summary: In this study, it was found that regorafenib treatment activated Wnt/beta-catenin signaling only in hepatoblast-like HCC cell lines and induced enrichment of markers associated with hepatic stem/progenitor cells. On the other hand, regorafenib resistant cells demonstrated diminished Wnt/beta-catenin signaling activity and enhanced TGF-beta signaling activity. The inhibition of TGF-beta pathway in combination with regorafenib administration might increase regorafenib-induced cell death in HCC tumors with aberrant activation in the Wnt/beta-catenin pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Applied
Zheng Gao, Deyin Kong, Wenxin Cai, Jianjun Zhang, Le Jia
Summary: The study found that CMP improved insulin resistance and energy metabolism, suppressed kidney dysfunction, relieved renal oxidative stress and inflammation in diabetic nephropathic mice. Western blot results suggested CMP reversed renal injury by modulating the PTEN/PI3K/Akt and Wnt-1/beta-catenin pathways. The typical characterizations of CMP with galactose major monosaccharide-compositions and proper molecular weight possibly contributed to its anti-diabetic nephropathic effects.
CARBOHYDRATE POLYMERS
(2021)
Article
Endocrinology & Metabolism
Sang Hyun Song, Dawool Han, Kyeonghui Park, Jo Eun Um, Seonghun Kim, Minhee Ku, Jaemoon Yang, Tae-Hyun Yoo, Jong In Yook, Nam Hee Kim, Hyun Sil Kim
Summary: Diabetic nephropathy is a common complication of diabetes. The newly discovered cell death mechanism called ferroptosis, induced by TGF-beta, is involved in kidney damage in diabetic nephropathy. BMP7, a known antagonist of TGF-beta, can inhibit TGF-beta-induced fibrosis and play a role in the regeneration of pancreatic beta cells in diabetic animal models.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Urology & Nephrology
Xinxin Pang, Xiaotao Hou, Chengxiao Hu, Shilong Lu, Huifang Gan, Huifei Yang, Shaowei Xiang, Jun Zhou, Hongjun Gao, Shuangqin Chen
Summary: This study found that TNC is upregulated in diabetic nephropathy patients and diabetic mice, and it induces proliferation and fibrosis of renal tubular interstitial cells through the beta-catenin pathway.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Hong Zhu, Jiarui Peng, Wei Li
Summary: The study demonstrated that FOXA1 transcriptionally suppresses SATB1 expression and inactivates the Wnt/beta-catenin signaling pathway, thereby inhibiting podocyte apoptosis and diabetic nephropathy progression.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Yoshifumi Takahata, Hiromasa Hagino, Ayaka Kimura, Mitsuki Urushizaki, Shiori Yamamoto, Kanta Wakamori, Tomohiko Murakami, Kenji Hata, Riko Nishimura
Summary: This review article summarizes the research progress on the functions and regulatory mechanisms of lubricin and growth differentiation factor 5 (Gdf5) in osteoarthritis (OA), as well as their roles in maintaining articular cartilage homeostasis and the development of OA. Molecular targeting of Prg4 and Gdf5 is expected to provide new insights into the etiology, pathogenesis, and potential treatment of OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agricultural Engineering
Yuekai Su, Jin Zhang, Zhichao Xu, Jingyu Li, Pengfei Wang, Zhenqiao Song, Guoqing Tian, Lei Li, Jingyuan Song, Jianhua Wang
Summary: The study revealed a correlation between tanshinone content and root color in Salvia miltiorrhiza roots, with lower tanshinone levels in white root lines. Downregulation of tanshinone biosynthesis genes in BG impacted tanshinone metabolic flow. Additionally, cytochrome P450 genes and transcription factors were identified as candidate genes for tanshinone synthesis and regulation.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Biochemistry & Molecular Biology
Li Wang, Hong-Lian Wang, Tong-Tong Liu, Hui-Yao Lan
Summary: This review discusses the diverse roles and signaling mechanisms of TGF-beta in diabetic nephropathy, focusing on latent versus active TGF-beta 1, TGF-beta receptors, and downstream Smad signaling molecules. The regulatory mechanisms of TGF-beta/Smad signaling in the development of DN, including Smad-dependent non-coding RNAs, are also dissected. Finally, potential therapeutic strategies for DN targeting TGF-beta signaling with various approaches are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Hao Zhang, Chuanchuan Zheng, Wei Chen, Xiaoqiang Li, Jinshu Wang, Taikun Wang, Qi Zhao, Hao Huang, Yiting Li, Chengliang Yang, Kegong Xie, Shengcai Pan, Binghao Wang, Chong Wang, Yujin Tang, Kai Li, Jia Liu, Liqiang Wang
Summary: Our study demonstrates that targeting Src with PP2 can inhibit Wnt/beta-catenin signaling and activate TGF-beta/Smad signaling, thus protecting against cartilage destruction in OA. This provides a potential therapeutic target for OA treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Qi Tong, Chen Zhang, Yan Tu, Junfeng Chen, Qing Li, Zhen Zeng, Feiyan Wang, Lianna Sun, Doudou Huang, Mingming Li, Shi Qiu, Wansheng Chen
Summary: The study successfully revealed the spatial distributions of different metabolites in the roots and aerial parts of Salvia miltiorrhiza through untargeted metabolomics research and mass spectrometry imaging, providing important insights for understanding the biosynthesis of bioactive metabolites in plants.