Topical Drug Delivery to the Posterior Segment of the Eye: Addressing the Challenge of Preclinical to Clinical Translation

The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

(2018) Christopher M. Adams et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases

(2017) Chiara Platania et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches

(2016) Evgeni Y. Zernii et al.   CNS & Neurological Disorders-Drug Targets

Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data

(2015) Eva M. del Amo et al.   EXPERIMENTAL EYE RESEARCH

Delivery of Topically Applied Calpain Inhibitory Peptide to the Posterior Segment of the Rat Eye

(2015) Taku Ozaki et al.   PLoS One

Multi-country real-life experience of anti-vascular endothelial growth factor therapy for wet age-related macular degeneration

(2014) Frank G Holz et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

CLINICAL EVALUATION OF PAZOPANIB EYE DROPS IN HEALTHY SUBJECTS AND IN SUBJECTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

(2014) Rishi Singh et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5-associated Liposomes

(2014) Benjamin M. Davis et al.   Small

Anti-angiogenic effects of the receptor tyrosine kinase inhibitor, pazopanib, on choroidal neovascularization in rats

(2011) Yousef Yafai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recent advances in the use of cell-penetrating peptides for medical and biological applications☆

(2009) Sonali B. Fonseca et al.   ADVANCED DRUG DELIVERY REVIEWS

Cell-penetrating peptide TAT-mediated delivery of acidic FGF to retina and protection against ischemia-reperfusion injury in rats

(2009) Yi Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cell penetrating peptide POD mediates delivery of recombinant proteins to retina, cornea and skin

(2009) Leslie N. Johnson et al.   VISION RESEARCH

Ocular novel drug delivery: impacts of membranes and barriers

(2008) Jaleh Barar et al.   Expert Opinion on Drug Delivery

Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema

(2008) John Doukas et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Safety Evaluation of Ocular Drug Delivery Formulations: Techniques and Practical Considerations

(2008) Brian G. Short   TOXICOLOGIC PATHOLOGY