Slit/Robo Signaling Pathway in Cancer; a New Stand Point for Cancer Treatment

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function

(2016) Katrin J. Svensson et al.   Cell Metabolism

Slit-Robo signaling

(2016) Heike Blockus et al.   DEVELOPMENT

srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer

(2016) Yuyang Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Slit and Receptor Tyrosine Phosphatase 69D Confer Spatial Specificity to Axon Branching via Dscam1

(2015) Dan Dascenco et al.   CELL

Roundabout4 Suppresses Glioma-Induced Endothelial Cell Proliferation, Migration and Tube Formation in Vitro by Inhibiting VEGR2-Mediated PI3K/AKT and FAK Signaling Pathways

(2015) Heng Cai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis

(2015) Helong Zhao et al.   Molecular Oncology

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

ARF6 Inhibition Stabilizes the Vasculature and Enhances Survival during Endotoxic Shock

(2014) C. T. Davis et al.   JOURNAL OF IMMUNOLOGY

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments

(2014) Céline Delloye-Bourgeois et al.   NATURE NEUROSCIENCE

Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution

(2014) Pavol Zelina et al.   NEURON

Characterization of the interaction between Robo1 and heparin and other glycosaminoglycans

(2013) Fuming Zhang et al.   BIOCHIMIE

Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits

(2013) Michael P. O’Donnell et al.   DEVELOPMENT

Favorable prognosis of operable non-small cell lung cancer (NSCLC) patients harboring an increased expression of tumor endothelial markers (TEMs)

(2013) Andreas Pircher et al.   LUNG CANCER

The Small GTPase ARF6 Stimulates  -Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis

(2013) A. H. Grossmann et al.   Science Signaling

Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability

(2012) Weiquan Zhu et al.   NATURE

A bigger picture: classical cadherins and the dynamic actin cytoskeleton

(2012) Aparna Ratheesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dystroglycan Organizes Axon Guidance Cue Localization and Axonal Pathfinding

(2012) Kevin M. Wright et al.   NEURON

Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis

(2011) Wei-Jie Zhou et al.   CELL RESEARCH

Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm

(2011) Nyall R London et al.   CURRENT OPINION IN HEMATOLOGY

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B

(2011) Alexander W. Koch et al.   DEVELOPMENTAL CELL

Glucocorticoid Regulation of SLIT/ROBO Tumour Suppressor Genes in the Ovarian Surface Epithelium and Ovarian Cancer Cells

(2011) Rachel E. Dickinson et al.   PLoS One

SLIT2 Attenuation during Lung Cancer Progression Deregulates  -Catenin and E-Cadherin and Associates with Poor Prognosis

(2010) R.-C. Tseng et al.   CANCER RESEARCH

The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline

(2010) H. A. Coleman et al.   DEVELOPMENT

Expression of Slit and Robo genes in the developing mouse heart

(2010) Caroline Medioni et al.   DEVELOPMENTAL DYNAMICS

Human ROBO1 is cleaved by metalloproteinases and γ-secretase and migrates to the nucleus in cancer cells

(2010) Motoaki Seki et al.   FEBS LETTERS

Mechanisms of Motility in Metastasizing Cells

(2010) Mahmut Yilmaz et al.   MOLECULAR CANCER RESEARCH

Repulsive axon guidance molecule Slit3 is a novel angiogenic factor

(2009) B. Zhang et al.   BLOOD

The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils

(2009) Soumitra Tole et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

(2009) Christopher A. Jones et al.   NATURE CELL BIOLOGY

Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity

(2009) Jia-Jean Yiin et al.   NEURO-ONCOLOGY

Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration

(2008) John A. Legg et al.   ANGIOGENESIS

Loss of tight junction barrier function and its role in cancer metastasis

(2008) Tracey A. Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Quantification of SLIT-ROBO transcripts in hepatocellular carcinoma reveals two groups of genes with coordinate expression

(2008) Mehmet Ender Avci et al.   BMC CANCER

Silencing of directional migration in roundabout4 knockdown endothelial cells

(2008) Sukhbir Kaur et al.   BMC CELL BIOLOGY

Slit-2 Induces a Tumor-suppressive Effect by Regulating β-Catenin in Breast Cancer Cells

(2008) Anil Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

(2008) Christopher A Jones et al.   NATURE MEDICINE