Protective Effect of Ethyl Pyruvate against Myocardial Ischemia Reperfusion Injury through Regulations of ROS-Related NLRP3 Inflammasome Activation

Ethyl pyruvate attenuates myocardial ischemia-reperfusion injury exacerbated by hyperglycemia via retained inhibitory effect on HMGB1

(2018) Sarah Soh et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Crosstalk between Nrf2 and Inflammasomes

(2018) Paulina Hennig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3: A Novel Mediator in Cardiovascular Disease

(2018) Wenyi Zhou et al.   Journal of Immunology Research

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

Molecular mechanisms of inflammasome signaling

(2017) Anukriti Mathur et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats

(2017) Zhen Qiu et al.   Oxidative Medicine and Cellular Longevity

Anti-apoptotic and myocardial protective effects of ethyl pyruvate after regional ischaemia/reperfusion myocardial damage in an in vivo rat model

(2017) HS Shim et al.   SINGAPORE MEDICAL JOURNAL

Forkhead box O (FOXO) 3 modulates hypoxia-induced autophagy through AMPK signalling pathway in cardiomyocytes

(2016) Y. Chi et al.   BIOSCIENCE REPORTS

Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries

(2016) Runkuan Yang et al.   Journal of Inflammation-London

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

Erythropoietin protects myocardium against ischemia–reperfusion injury under moderate hyperglycemia

(2014) Ji Hae Jun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NLRP3 Inflammasome as a Novel Player in Myocardial Infarction

(2014) Masafumi Takahashi   International Heart Journal

Erythropoietin Protects Cardiomyocytes from Cell Death during Hypoxia/Reperfusion Injury through Activation of Survival Signaling Pathways

(2014) Asiya Parvin A et al.   PLoS One

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

(2013) Øystein Sandanger et al.   CARDIOVASCULAR RESEARCH

Erythropoietin-activated ERK/MAP kinase enhances GATA-4 acetylation via phosphorylation of serine 261 of GATA-4

(2012) Ji Hae Jun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Control of innate and adaptive immunity by the inflammasome

(2012) Ceren Ciraci et al.   MICROBES AND INFECTION

Role of p38 inhibition in cardiac ischemia/reperfusion injury

(2011) Sarawut Kumphune et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury

(2011) Jun Yoshioka et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY