Article
Biochemistry & Molecular Biology
Christine Schweikl, Sigrun Maier-Wohlfart, Holm Schneider, Jung Park
Summary: Pathogenic variants of the gene Eda cause X-linked hypohidrotic ectodermal dysplasia (XLHED), which disrupt bone homeostasis by affecting the activity of osteoclasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Clara-Sophie Kossel, Mandy Wahlbuhl, Sonia Schuepbach-Mallepell, Jung Park, Christine Kowalczyk-Quintas, Michaela Seeling, Klaus von der Mark, Pascal Schneider, Holm Schneider
Summary: X-linked hypohidrotic ectodermal dysplasia, caused by a genetic deficiency of ectodysplasin A1 (EDA1), presents with hypodontia, hypotrichosis, and hypohidrosis. The Tabby mouse, a natural model of EDA1 deficiency, exhibits a kink in the tail possibly due to a skin proliferation defect. Early prenatal replacement of EDA1 can prevent tail kinking and normalize vertebral bone density in Tabby mice.
FRONTIERS IN GENETICS
(2021)
Article
Pediatrics
Victoria-Eugenia Garcia-Martinez, Ximo Galiana-Valles, Otilia Zomeno-Alcala, Raquel Rodriguez-Lopez, Carmen Llena, Maria del Carmen Martinez-Romero, Encarna Guillen-Navarro
Summary: This article describes an 11-year-old Chinese boy with oligodontia, characterized by conical-shaped teeth as the main phenotype and other mild ectodermal signs. Genetic analysis revealed compound heterozygous pathogenic variants in the WNT10A gene and a homozygous polymorphism in the EDAR gene. The findings suggest that WNT10A mutations are primarily responsible for the dental phenotype, while the EDAR polymorphism may attenuate the severity of other ectodermal signs.
Article
Genetics & Heredity
Xingyu Liu, Yuming Zhao, Junxia Zhu
Summary: A novel mutation (c.593G > A, p. Gly198Glu) in the collagen domain of EDA was identified, which impairs the receptor-binding activity of EDA and the transcriptional activity of NF-kappa B, leading to HED.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Peifen Shan, Xiaole Wang, Yanyan Zhang, Zhisheng Teng, Yunxiao Zhang, Qiu Jin, Jiefan Liu, Jianfeng Ma, Xin Nie
Summary: p75NTR plays a crucial role in tooth development and its involvement in odonto/osteogenic differentiation may be regulated through the NF-kappa B pathway.
Article
Oncology
Thomas A. Burley, Emma Kennedy, Georgia Broad, Melanie Boyd, David Li, Timothy Woo, Christopher West, Eleni E. Ladikou, Iona Ashworth, Christopher Fegan, Rosalynd Johnston, Simon Mitchell, Simon P. Mackay, Andrea G. S. Pepper, Chris Pepper
Summary: In this study, the researchers evaluated the effects of an NF-kappa B inducing kinase (NIK) inhibitor, CW15337, on primary chronic lymphocytic leukemia (CLL) cells, CLL and multiple myeloma (MM) cell lines, and normal B- and T-lymphocytes. They found that CW15337 induced apoptosis and inhibited the non-canonical NF-kappa B signaling pathway, reversing BCL2 family-mediated resistance. The combination of CW15337 with fludarabine or ABT-199 showed synergistic cytotoxic effects.
Review
Biochemistry & Molecular Biology
Li Tao, Xiaomeng Ren, Wenhui Zhai, Zheng Chen
Summary: The non-canonical NF-kappa B signaling pathway plays a crucial role in liver diseases by regulating liver homeostasis and participating in various pathological processes. Small-molecule inhibitors targeting this pathway have shown potential in the treatment of liver injuries.
Article
Immunology
Yu Zhang, Dan Zhang, Tingting Meng, Peng Tian, Jianlin Chen, Anbang Liu, Yan Zheng, Guohai Su
Summary: Breast cancer is a common cancer among women worldwide, and the chemotherapy drug DOX has the potential to prolong survival but can cause cardiovascular toxicity. The study found that SGK1 plays an important role in DOX-induced cardiotoxicity, with upregulated expression accompanied by increased levels of inflammatory factors. Inhibition of SGK1 can suppress the production of inflammatory factors and apoptosis of cardiomyocytes, providing cardioprotective effects. In addition, targeting SGK1 can inhibit the proliferation of breast cancer cells. The study suggests that inhibiting SGK1 may be an effective treatment strategy for breast cancer that has both tumor-killing and cardioprotective functions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Vivian Reinhold, Stina Syrjanen, Minna Kankuri-Tammilehto
Summary: This study reports a severe case of oligodontia in a female patient with the EDA gene variant c.742-2A>G. The results strongly suggest that this variant is pathogenic and the oligodontia in the patient is exceptionally severe. Early identification of this variant is crucial for planning adequate treatment and follow-up.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Plant Sciences
Dong Xie, Chao Wu, Dan Wang, Bahaji Azami Nisma Lena, Ningning Liu, Guan Ye, Mingyu Sun
Summary: The study demonstrated that WFC inhibits gastric intestinal metaplasia and gastric dysplasia associated with inflammation by regulating the NF-kappa B pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaohe Li, Qing Liang, Shaoyan Gao, Qiuyan Jiang, Fangxia Zhang, Ruiqin Zhang, Hao Ruan, Shuangling Li, Jiaoyan Luan, Ruxia Deng, Honggang Zhou, Hui Huang, Cheng Yang
Summary: Lenalidomide has potential anti-fibrotic effects by suppressing inflammation-related signaling pathways, thereby reducing pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Liangge He, Xue Yu, Yulin Zhao, Haoran Lin, Yong Zhang, Danqi Lu
Summary: In this study, Epinephelus coioides soluble TLR5 (TLR5S) was identified as a negative regulator of the NF-kappa B signaling pathway. TLR5S specifically responded to Vibrio flagellin and inhibited flagellin-induced activation of NF-kappa B signaling and cytokine expression. This discovery provides insights into the negative regulation of immune signaling and the restoration of homeostasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Nanxin Ma, Jian Guo, Xiaolong Wu, Zhenzhong Liu, Tian Yao, Qian Zhao, Ben Li, Fengjie Tian, Xiaoyan Yan, Wenping Zhang, Yulan Qiu, Yi Gao
Summary: This article systematically reviews and analyzes the changes in TLR4 signaling pathway-related proteins induced by arsenic exposure through meta-analysis, providing important theoretical basis for understanding the toxicity of arsenic and the mechanism of immune system damage.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yiqun Wu, Baoxin Tao, Kengliang Lan, Yihan Shen, Wei Huang, Feng Wang
Summary: This study assessed the accuracy of a real-time dynamic navigation system in zygomatic implant surgery and summarized device-related negative events and their management. The results showed that navigation-supported zygomatic implantation is an accurate and reliable surgical approach, but technical negative events in the navigation process should be given attention.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Feng Wang, Shengchi Fan, Wei Huang, Yihan Shen, Chaolun Li, Yiqun Wu
Summary: The study aimed to investigate the feasibility and accuracy of using surgical navigation for ZI placement in the treatment of extensive maxillary defects. Through virtual planning and surgical navigation, 27 ZIs were successfully placed without any loss of osseointegrated implants. Surgical navigation facilitated the accurate placement of ZIs in patients with extensive maxillary defects.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Wenying Wang, Minjie Zhuang, Shunshun Li, Yue Shen, Rong Lan, Yiqun Wu, Feng Wang
Summary: This study aimed to explore and compare the learning curves for static computer-assisted surgery (s-CAIS) and dynamic computer-assisted implant surgery (d-CAIS) in beginners. The results showed that there was a learning curve effect in d-CAIS but not in s-CAIS in vitro tests. As the practice progressed, accuracy improved in the d-CAIS group but not in the s-CAIS group.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2023)
Article
Chemistry, Multidisciplinary
Zhu-Jun Wang, Zhihua Liang, Xiao Kong, Xiaowen Zhang, Ruixi Qiao, Jinhuan Wang, Shuai Zhang, Zhiqun Zhang, Chaowu Xue, Guoliang Cui, Zhihong Zhang, Dingxin Zou, Zhi Liu, Qunyang Li, Wenya Wei, Xu Zhou, Zhilie Tang, Dapeng Yu, Enge Wang, Kaihui Liu, Feng Ding, Xiaozhi Xu
Summary: This study investigates the etching and growth of graphene in a two-dimensional confined space and reveals that the active bottom graphene layer can feed the growth of the top graphene layer with high efficiency, providing important insights for the design of high-efficiency catalysts.
Article
Surgery
Baoxin Tao, Yuan Feng, Xingqi Fan, Kengliang Lan, Minjie Zhuang, Shigang Wang, Feng Wang, Xiaojun Chen, Yiqun Wu
Summary: This in vitro study validates the high accuracy of a novel image-guided hybrid robotic system (HRS-DIS) for dental implant surgery.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Rong Lan, Yiqun Wu, Qinggang Dai, Feng Wang
Summary: This study reviewed the pathogenic mechanisms and clinical manifestations of syndromes with tooth agenesis, finding that the causes of syndromic TA are highly complex, including gene mutations, abnormal crucial molecules, and chromosomal anomalies.
Article
Dentistry, Oral Surgery & Medicine
Yuwei Gu, Dingzhong Zhang, Baoxin Tao, Feng Wang, Xiaojun Chen, Yiqun Wu
Summary: This study aims to establish a new technique for obtaining the BIC area (BICA) between zygomatic implants and zygomatic bone based on post-operative CBCT images. The technique involves 3D image registration and segmentation to eliminate metal-induced artifacts. The results show that the new technique is more reliable than conventional 2D linear measurements.
DENTOMAXILLOFACIAL RADIOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Xinyan Lin, Xinbo Yu, Feng Wang, Yiqun Wu
Summary: This study assessed marginal bone level change (MBLc), clinical outcomes for soft tissue, and survival rates for immediately restored implants with simultaneous guided bone regeneration (GBR). The results showed that implants with peri-implant gap filling had less marginal bone loss and more predictable soft tissue parameters compared to implants with gap with dehiscence/fenestration grafting. However, more evidence is needed to determine whether immediate provisional prostheses should be used in cases of simultaneous bone defects augmentation.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shufang Jin, Hailong Ma, Xiaowan Ling, Baoxin Tao, Feng Wang, Yiqun Wu
Summary: This study investigated the effects of zygomatic implant placement on the maxillary sinus using radiographic and clinical indicators. The results showed that the thickness of the sinus membrane significantly increased after bilateral zygomatic implant placement, which may lead to maxillary sinus mucositis and osteitis.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Baoxin Tao, Xinbo Yu, Wenying Wang, Haowei Wang, Xiaojun Chen, Feng Wang, Yiqun Wu
Summary: In this study, a deep learning-based automatic segmentation method was proposed for zygomatic bones from cone-beam computed tomography (CBCT) images. The results showed that the proposed method outperformed dentists in terms of accuracy and efficiency. This automatic segmentation model for zygomatic bone has high accuracy and efficiency and is clinically significant for preoperative digital planning, zygoma reconstruction, orbital surgery, zygomatic implant surgery, and orthodontics.
JOURNAL OF DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Xinbo Yu, Baoxin Tao, Feng Wang, Yiqun Wu
Summary: This study evaluated the accuracy of dynamic computer-assisted implant surgery (dCAIS) and compared it with static computer-assisted implant surgery (sCAIS) and freehand implant placement (FH). The results showed that dynamic navigation improved the accuracy of implant placement.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Cailing Jiang, Kang Yu, Yihan Shen, Feng Wang, Qinggang Dai, Yiqun Wu
Summary: The objective of this study was to investigate the associations between PAX9 mutations and clinical features of non-syndromic tooth agenesis patients. Through whole exome sequencing, mutations in PAX9 gene were identified in non-syndromic tooth agenesis patients, and conservation analysis and three-dimensional structure prediction were conducted to analyze the mutated proteins. The study found that PAX9 mutations were associated with non-syndromic tooth agenesis and caused functional impairments of the PAX9 protein.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Engineering, Biomedical
Yuan Feng, BaoXin Tao, JiaCheng Fan, ShiGang Wang, JinQiu Mo, YiQun Wu, QingHua Liang
Summary: In this study, a novel method for automatically reconstructing a three-dimensional model of the maxillary anterior tooth crown is proposed. A pose estimation network and a shape estimation network are developed to jointly estimate the crown point cloud. The results show that the proposed method can automatically and accurately reconstruct the missing maxillary anterior tooth crown, indicating promising application prospects.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ruben Davo, Shengchi Fan, Feng Wang, Yiqun Wu
Summary: The objective of this study was to evaluate the long-term clinical outcomes and complications of severely atrophic edentulous maxillae treated with the quad zygoma protocol (QZP) and Anatomy-Guided Approach (AGA). The study found that this treatment approach had a predictable and high implant survival rate in the long term, and the implementation of an immediate loading protocol offered potential benefits in stabilizing zygomatic implants with cross-arch stabilization.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jie Li, Kun Feng, Lijuan Ye, Yuelian Liu, Yuanyuan Sun, Yiqun Wu
Summary: This study investigated the influence of radiation therapy on dental implants in patients with head and neck cancer. The findings showed that peri-implant bone resorption worsened after radiotherapy, especially when the radiation dose exceeded 40 Gy. However, the presence of implants did not alter the distribution of radiation dose.
CLINICAL ORAL INVESTIGATIONS
(2022)