A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis

Association of chronic rhinosinusitis with nasal polyps and asthma: Clinical and radiological features, allergy and inflammation markers

(2018) Jūratė Staikūnienė et al.   Medicina-Lithuania

EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists

(2018) W.J. Fokkens et al.   RHINOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

(2017) Florence Demenais et al.   NATURE GENETICS

Diversity in non-repetitive human sequences not found in the reference genome

(2017) Birte Kehr et al.   NATURE GENETICS

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

(2017) Manuel A Ferreira et al.   NATURE GENETICS

A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma

(2017) Dirk Smith et al.   PLoS Genetics

Rare coding variants pinpoint genes that control human hematological traits

(2017) Abdou Mousas et al.   PLoS Genetics

Whole genome characterization of sequence diversity of 15,220 Icelanders

(2017) Hákon Jónsson et al.   Scientific Data

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

Weighting sequence variants based on their annotation increases power of whole-genome association studies

(2016) Gardar Sveinbjornsson et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

A review of nasal polyposis

(2016) Jonathan Newton   Therapeutics and Clinical Risk Management

Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms

(2015) Hansjörg Baurecht et al.   AMERICAN JOURNAL OF HUMAN GENETICS

15-Lipoxygenase inhibitors: a patent review

(2015) Hamid Sadeghian et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

(2015) Lavinia Paternoster et al.   NATURE GENETICS

Large-scale whole-genome sequencing of the Icelandic population

(2015) Daniel F Gudbjartsson et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells

(2015) Åsa Brunnström et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

(2015) Louise V Wain et al.   Lancet Respiratory Medicine

Biology of nasal polyposis

(2014) Whitney W. Stevens et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Influence of Aspirin on Release of Eoxin C4, Leukotriene C4 and 15-HETE, in Eosinophilic Granulocytes Isolated from Patients with Asthma

(2013) Anna James et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma

(2012) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis

(2011) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular Basis for the Reduced Catalytic Activity of the Naturally Occurring T560M Mutant of Human 12/15-Lipoxygenase That Has Been Implicated in Coronary Artery Disease

(2011) Kathrin Schurmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A microarray study of gene expression profiles in nasal polyps

(2010) Beata Rostkowska-Nadolska et al.   AURIS NASUS LARYNX

Mice Lacking 12/15-Lipoxygenase Have Attenuated Airway Allergic Inflammation and Remodeling

(2008) Cecilia K. Andersson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

(2008) S. Feltenmark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma

(2008) Hans-Erik Claesson   PROSTAGLANDINS & OTHER LIPID MEDIATORS

A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease

(2007) Themistocles L. Assimes et al.   ATHEROSCLEROSIS