Transparent tissues bring cells into focus for microscopy

A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing

(2018) Tatsuya C. Murakami et al.   NATURE NEUROSCIENCE

Three-dimensional intact-tissue sequencing of single-cell transcriptional states

(2018) Xiao Wang et al.   SCIENCE

Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy

(2018) Guiping Wang et al.   Scientific Reports

Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy

(2017) Yongxin Zhao et al.   NATURE BIOTECHNOLOGY

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity

(2017) Nobuyuki Tanaka et al.   Nature Biomedical Engineering

CUBIC pathology: three-dimensional imaging for pathological diagnosis

(2017) Satoshi Nojima et al.   Scientific Reports

Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems

(2015) Evan Murray et al.   CELL

Expansion microscopy

(2015) F. Chen et al.   SCIENCE

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis

(2014) Etsuo A. Susaki et al.   CELL

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

Three-dimensional imaging of solvent-cleared organs using 3DISCO

(2012) Ali Ertürk et al.   Nature Protocols