Safeguarding clinical translation of pluripotent stem cells with suicide genes

Protecting against wayward human induced pluripotent stem cells with a suicide gene

(2012) Fuyi Cheng et al.   BIOMATERIALS

Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells

(2012) Fei Chen et al.   BIOMATERIALS

A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

(2012) Qiurong Ding et al.   Cell Stem Cell

A Scalable Approach to Prevent Teratoma Formation of Human Embryonic Stem Cells

(2012) Zhili Rong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The promise of induced pluripotent stem cells in research and therapy

(2012) Daisy A. Robinton et al.   NATURE

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A

(2012) R. Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Targeting of Genetically Engineered Mesenchymal Stem Cells to Tumor Stroma Microenvironments Using Tissue-Specific Suicide Gene Expression Suppresses Growth of Hepatocellular Carcinoma

(2011) Hanno Niess et al.   ANNALS OF SURGERY

Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis

(2011) Man Tong et al.   CELL RESEARCH

Derivation of Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling

(2011) Kamileh Narsinh et al.   CIRCULATION RESEARCH

Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors

(2011) Y Zhao et al.   GENE THERAPY

Safeguarding Nonhuman Primate iPS Cells With Suicide Genes

(2011) Bonan Zhong et al.   MOLECULAR THERAPY

Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

Karyotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells

(2011) Seth M Taapken et al.   NATURE BIOTECHNOLOGY

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells

(2011) Chad Tang et al.   NATURE BIOTECHNOLOGY

Mifepristone-Inducible Caspase-1 Expression in Mouse Embryonic Stem Cells Eliminates Tumor Formation but Spares Differentiated Cells In Vitro and In Vivo

(2011) Yi Wang et al.   STEM CELLS

The bioethics of stem cell research and therapy

(2010) Insoo Hyun   JOURNAL OF CLINICAL INVESTIGATION

Systematic Comparison of Constitutive Promoters and the Doxycycline-Inducible Promoter

(2010) Jane Yuxia Qin et al.   PLoS One

Quantitative Comparison of Constitutive Promoters in Human ES cells

(2010) Karin Norrman et al.   PLoS One

Selective Removal of Undifferentiated Embryonic Stem Cells from Differentiation Cultures Through HSV1 Thymidine Kinase and Ganciclovir Treatment

(2010) Ortwin Naujok et al.   Stem Cell Reviews and Reports

Genetic Control of Wayward Pluripotent Stem Cells and Their Progeny after Transplantation

(2009) Maija Kiuru et al.   Cell Stem Cell

Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy

(2009) Chunxiao Wu et al.   MOLECULAR THERAPY

Variation in the safety of induced pluripotent stem cell lines

(2009) Kyoko Miura et al.   NATURE BIOTECHNOLOGY

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

(2009) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

Zinc finger nuclease technology heralds a new era in mammalian transgenesis

(2009) Fabienne Le Provost et al.   TRENDS IN BIOTECHNOLOGY

Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research

(2008) Stefanie Liedtke et al.   BIOLOGICAL CHEMISTRY

Neuron-like Differentiation and Selective Ablation of Undifferentiated Embryonic Stem Cells Containing Suicide Gene with Oct-4 Promoter

(2008) Akira Hara et al.   STEM CELLS AND DEVELOPMENT