Article
Agronomy
Xiaolu Jin, Guanggen Huang, Zheng Luo, Yongfei Hu, Dan Liu
Summary: The potential effects of oregano essential oil (OEO) on preventing necrotic enteritis (NE) caused by Clostridium perfringens (Cp) in chickens were evaluated in this study. The results showed that OEO had significant effects on increasing body weight gain and reversing the dropped feed intake. OEO also alleviated histopathological changes in the ileums of broiler chickens and had limited effects on tight junction-related gene expressions. OEO is proposed as a promising substitute for antibiotics against NE induced by Cp during poultry production.
Article
Plant Sciences
Paola Zinno, Barbara Guantario, Gabriele Lombardi, Giulia Ranaldi, Alberto Finamore, Sofia Allegra, Michele Massimo Mammano, Giancarlo Fascella, Antonio Raffo, Marianna Roselli
Summary: Recent studies have shown that oregano essential oils have remarkable biological activities and potential innovative applications in the food and pharmaceutical industries. This study characterized the chemical composition and biological activities of essential oils from two different genotypes of Oregano vulgare, which were widely cultivated in Sicily. The results demonstrated that one genotype with a less complex chemical profile and higher levels of carvacrol, the most active compound, exhibited high antimicrobial activity and could be used as a control agent against foodborne pathogens.
Article
Agriculture, Multidisciplinary
Xiaohan Liu, Yan Zhao, Jian Mu, Jinjie Zhang, Ang Zhang
Summary: This study established a discriminant model based on stable isotopes and mineral elements content in concentrated apple juice to determine its geographic origin. Statistical analyses were employed for regional classification of samples, ultimately identifying eight key variables for characterizing the production area. The results showed that carbon and oxygen isotopes combined with certain mineral elements can effectively indicate the origin of concentrated apple juice.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Food Science & Technology
Antoon Lievens, Valentina Paracchini, Linda Garlant, Danilo Pietretti, Alain Maquet, Franz Ulberth, Athanasios Ladavos, Eleni Mazarakioti
Summary: DNA technology, particularly Next Generation Sequencing (NGS) and metabarcoding, has become popular for compositional analysis of food at the molecular level. By using digital PCR and NGS, the purity of oregano samples from the European market was checked, revealing the presence of adulterants and contaminants. While NGS showed high potential for compositional analysis, its quantitative information was deemed unreliable, requiring other techniques for assessing food authenticity.
Article
Plant Sciences
Dimitrios Mertzanidis, Alexandros Nakas, Andreana N. Assimopoulou, Stella Kokkini
Summary: This study examined the white oregano and black oregano used by the inhabitants of Mount Belles villages in Greece. White oregano was found in lowland regions dominated by certain forest habitats, while black oregano was collected from higher altitudes with a different forest habitat. The white oregano had larger and more noticeable glandular hairs and higher essential oil content compared to the black oregano. The essential oil composition and aroma profile of black oregano were different from those of white oregano.
Review
Infectious Diseases
Larisa Bora, Stefana Avram, Ioana Zinuca Pavel, Delia Muntean, Sergio Liga, Valentina Buda, Daniela Gurgus, Corina Danciu
Summary: Origanum vulgare L. essential oil (OvEo) has gained attention in dermatology due to its cosmeceutical potential and pharmacological activities. It has been extensively studied for its antimicrobial and anti-inflammatory activities, showing potential in wound healing and treatment of skin disorders. Modern formulations, such as microemulsions and nanoemulsions, have also been developed for topical application.
Article
Agriculture, Dairy & Animal Science
Ghasem Rashidian, Javad Tahmasebi Boldaji, Simona Rainis, Marko D. Prokic, Caterina Faggio
Summary: The study found that oregano extract has significant effects on the growth and immune system of zebrafish, improving their antioxidant response and survival rate against bacterial invasion. Zebrafish showed the greatest benefits with 1% dietary inclusion of the extract, suggesting the potential use of Origanum vulgare in the aquaculture industry and zebrafish as an appropriate model for nutrition studies.
Article
Chemistry, Applied
Jing Qi, Yingying Li, Chen Zhang, Cheng Wang, Juanqiang Wang, Wenping Guo, Shouwei Wang
Summary: This study demonstrates that mineral elements analysis assisted by machine learning can effectively distinguish the origin of pork samples within China, leading to a high-performance tracing model with a superior accuracy rate of 95.71% and close to one area under the curve.
Article
Immunology
Na Yao, Qiong Xu, Jia-Kang He, Ming Pan, Zhao-Feng Hou, Dan-Dan Liu, Jian-Ping Tao, Si-Yang Huang
Summary: The study demonstrated that carvanol, the main component of Origanum vulgare essential oil, showed potential as a new and effective drug for treating toxoplasmosis by inhibiting the proliferation of Toxoplasma gondii.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Stefana Avram, Larisa Bora, Lavinia Lia Vlaia, Ana Maria Mut, Gheorghe-Emilian Olteanu, Ioana Olariu, Ioana Zinuca Magyari-Pavel, Daliana Minda, Zorita Diaconeasa, Paula Sfirloaga, Mohd Adnan, Cristina Adriana Dehelean, Corina Danciu
Summary: This study evaluated the morphology, release, permeation, biocompatibility, and anti-angiogenic effects of polymeric-micelles-based hydrogel loaded with oregano essential oil. The results showed that the hydrogel exhibited sustained release of the essential oil and enhanced anti-angiogenic effects, while being well tolerated and non-irritative. This is the first evidence of in vivo anti-angiogenic effects of a polymeric-micelle-loaded oregano essential oil, suggesting its potential application in the treatment of fibroepithelial polyps and other angiogenesis-related conditions.
Article
Mycology
Stefanie Bressan Waller, Marcia Kutscher Ripoll, Luciele Pereira de Melo, Pereira de Melo, Angelita dos Reis Gomes, Otavia de Almeida Martins, Marlete Brum Cleff, Joao Roberto Braga de Mello, Renata Osorio de Faria, Mario Carlos Araujo Meireles
Summary: This study investigated the antifungal activity and action mechanism of four polar extracts and one essential oil (EO) from oregano against itraconazole (ITZ)-susceptible and ITZ-resistant dermatophytes. The results showed that the decoction extract (DEC) demonstrated significant antifungal activity, followed by the 10-minute and 60-minute infusions extracts (INF10 and INF60); hydroxibenzoic acid was the most prevalent compound in all polar extracts. For the EO, carvacrol was the major compound.
JOURNAL DE MYCOLOGIE MEDICALE
(2023)
Article
Engineering, Chemical
Omkulthom Al Kamaly, Ashwag S. Alanazi, Raffaele Conte, Hamada Imtara
Summary: In this study, the components of Origanum vulgare essential oil were analyzed using GC-MS, and the antibacterial efficacy was evaluated using the disc diffusion assay. Molecular docking was used to assess the antimicrobial efficacy against specific microbial proteins. The results identified 18 compounds in the essential oil, with terpinen-4-ol, beta-terpineol, 3-epimoretenol, and alpha-terpineol being the main substances. The essential oil showed significant inhibition against Staphylococcus aureus and Escherichia coli. It can be concluded that Origanum vulgare essential oil has potential as a nutraceutical for the treatment of infectious diseases.
Article
Food Science & Technology
Yuanpeng Hao, Jingyi Li, Wenying Zhang, Meiyu Sun, Hui Li, Fei Xia, Hongxia Cui, Hongtong Bai, Lei Shi
Summary: This study evaluated the essential oil yields and chemical compositions of different oregano cultivars, finding significant differences in oil yield among plant parts and chemical profiles among cultivars. The carvacrol content in the oils was closely related to their activity against Staphylococcus aureus, suggesting the potential of high antibacterial oregano essential oils as bactericides in the food industry.
Article
Chemistry, Multidisciplinary
Calin Jianu, Alexandra Teodora Lukinich-Gruia, Matilda Radulescu, Marius Mioc, Alexandra Mioc, Codruta Soica, Albert Titus Constantin, Ioan David, Gabriel Bujanca, Roxana Ghircau Radu
Summary: This investigation evaluates the chemical composition and antioxidant properties of Origanum vulgare var. aureum L. essential oil (OEO). The main compounds of the OEO are gamma-terpinene, para-cymene, germacrene, beta-trans-ocimene, and cis-beta-ocimene. The OEO exhibits significant scavenging effects in various antioxidant assays and may potentially inhibit ROS-producing enzymes, making it a valuable natural antioxidant source.
APPLIED SCIENCES-BASEL
(2023)
Article
Biology
Lidija Milenkovic, Zoran S. Ilic, Ljubomir Sunic, Nadica Tmusic, Ljiljana Stanojevic, Jelena Stanojevic, Dragan Cvetkovic
Summary: The study showed that growing thyme, marjoram, and oregano under shading conditions resulted in higher essential oil yields and better antioxidant activity.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Applied
Sara Vitalini, Luca Nalbone, Cristian Bernardi, Marcello Iriti, Rosaria Costa, Nicola Cicero, Filippo Giarratana, Lisa Vallone
Summary: This study evaluated the chemical composition and in vitro antimicrobial activity of store-bought parsley and ginger essential oils. Parsley essential oil showed the best compromise between sensory influence and antimicrobial activity. It effectively prevented the growth of A. flavus in cheese.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Luca Gammeri, Claudia Panzera, Fabrizio Calapai, Nicola Cicero, Sebastiano Gangemi
Summary: Chronic urticaria is a pathological condition characterized by wheals and angioedema lasting for more than six weeks. Treatment commonly involves antihistamines, but corticosteroids and monoclonal antibodies can also be used. Herbal medicine is an alternative approach, with some herbs possessing anti-inflammatory, anti-allergic, and antioxidant properties.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Giovanna Loredana La Torre, Archimede Rotondo, Andrea Salvo
Summary: This study investigates the effects of different vineyard management practices on the concentrations of biogenic amines (BAs) in experimental red wines. The results indicate a correlation between vine management and the content of BAs in the wine.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Eleonora Di Salvo, Marco Casciaro, Concetto Mario Giorgianni, Nicola Cicero, Sebastiano Gangemi
Summary: Aging is a natural process that affects all living beings, leading to a decline in their ability to adapt to external changes. Oxidative stress, particularly from halogen compounds like chloride, plays a significant role in this process.
Review
Biochemistry & Molecular Biology
Lucia Peterle, Serena Sanfilippo, Francesco Borgia, Nicola Cicero, Sebastiano Gangemi
Summary: Alopecia areata is characterized by non-scarring hair loss and oxidative stress plays an important role in its pathogenesis. Oxidative stress markers are altered in patients with alopecia areata, indicating a pro-oxidative status. Oxidative stress induces the destabilization of the hair follicle immune-privileged site through the activation of MICA and NKG2D receptors. In addition, autophagy is reduced during the progression of alopecia areata. Potential biomarkers of oxidative stress in alopecia areata include MDA, AGEs, and IMA. JAK inhibitors and nutraceuticals that modulate oxidative stress balance show promise as therapeutic tools.
Review
Biochemistry & Molecular Biology
Alessandro Allegra, Nicola Cicero, Giuseppe Mirabile, Concetto Mario Giorgianni, Sebastiano Gangemi
Summary: Lower-than-normal platelet counts are a hallmark of immune thrombocytopenia, an acquired autoimmune illness. The lack of a valid biomarker or gold-standard diagnostic test leads to high rates of misdiagnosis. Recent studies have revealed various factors involved in the disease's etiology, such as immune-activating substances and genetic mutations. This review aims to compile information on novel biomarkers for immune thrombocytopenia to enhance patient management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Vita Di Stefano, Nicola Cicero, Maria Grazia Melilli, Enrico Ganguzza, Massimo Lucarini, Alessandra Durazzo
Summary: Quality control is crucial for protein supplements aimed at a large consumer base like sportspeople. A study analyzed 16 sports supplements from various European countries and found discrepancies in amino acid quantities compared to the label. Some samples exceeded the maximum tolerance regulated by the European Commission, while others had amino acid concentrations exceeding the analytical tolerance percentage. However, essential and branched amino acid supplements were found to conform to the declared quantities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kristian Riolo, Archimede Rotondo, Giovanna Loredana La Torre, Ylenia Marino, Gianluca Antonio Franco, Rosalia Crupi, Roberta Fusco, Rosanna Di Paola, Sabrina Oliva, Giuseppe De Marco, Domenico Savastano, Salvatore Cuzzocrea, Enrico Gugliandolo, Alessia Giannetto
Summary: In this study, protein hydrolysates (BPHs) produced from black soldier fly larvae were characterized and evaluated for their potential biological activity. The BPHs showed antioxidant activity and could protect cells from oxidative stress. These findings suggest that BPHs could be used as ingredients to promote animal health in feed formulations.
Article
Chemistry, Analytical
Gemma De Grazia, Lorenzo Cucinotta, Danilo Sciarrone, Paola Donato, Emanuela Trovato, Nacera Riad, Mohamed El Hattab, Luigi Mondello, Archimede Rotondo
Summary: In this study, novel compounds were isolated from brown algae using preparative multidimensional gas chromatography. The correct 3D structures were determined by matching the experimental NMR data with density functional theory simulations. This research provides a new approach for structure elucidation of highly asymmetric molecules.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Applied
Giovanna Loredana La Torre, Rossella Vadala, Nicola Cicero, Giovanni Lo Cascio, Antonello Cicero, Vittorio Calabrese, Vincenzo Ferrantelli, Cinzia Ingallina, Andrea Salvo
Summary: This study investigated the impact of a new bio-packaging on histamine formation in mackerel for the first time. A treatment with innovative polymeric film and a soaking procedure in liquid new biomaterial were adopted to monitor the preservation of fresh fish samples. Ultra HPLC diode array detection (UHPLC-DAD) analyses showed that histamine levels were affected by application of biomaterial after 7 days. The new biofilm extended the shelf-life and showed potential in preventing histamine biosynthesis.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Clara Naccari, Nicola Cicero, Rossella Vadala, Giovanni Bartolomeo, Ernesto Palma
Summary: The agro-food surplus is a valuable renewable resource with economic and environmental impact. Before using agro-food wastes, toxicological analysis is necessary to prevent potential risks. This study evaluated the metals content in agro-food wastes and found that most of them can be safely reused, especially as animal feed supplements.
NATURAL PRODUCT RESEARCH
(2023)
Review
Nutrition & Dietetics
Santino Caserta, Claudia Genovese, Nicola Cicero, Valeria Toscano, Sebastiano Gangemi, Alessandro Allegra
Summary: The gut microbiota, a community of bacteria in the gastrointestinal tract, undergoes changes in response to various factors such as diseases, diet, antibiotics, and probiotics. Dysbiosis, characterized by altered communication between the host and the microbes, is associated with obesity, diabetes, cancer, and cardiovascular diseases. Certain plants have been shown to have anticancer properties and the ability to modulate the gut microbiota. This review highlights the potential use of medicinal plants in improving gut dysbiosis and aiding cancer treatment.
Review
Nutrition & Dietetics
Fabiana Furci, Nicola Cicero, Alessandro Allegra, Sebastiano Gangemi
Summary: Acute leukaemia is a common cancer in children and younger adults, but its etiology is still not fully understood. Studies have shown that dysbiosis of gut microbiota can lead to an inflammatory immune response and contribute to the development of leukaemia. This paper examines the role of dietary factors and gut microbiota alterations in leukaemia development and proposes potential preventive and therapeutic strategies.
Article
Green & Sustainable Science & Technology
Rossella Vadala, Giovanna Lo Vecchio, Rossana Rando, Michelangelo Leonardi, Nicola Cicero, Rosaria Costa
Summary: The present study developed a cost-effective, energy-saving, and ecofriendly methodology for producing ethanol from citrus fruit waste. This involved pretreating the waste through physical means, followed by enzymatic hydrolysis and fermentation. The process resulted in the production of 40.1 g/L ethanol in 48 hours, and an additional fed batch step increased the ethanol yield to 52.3 g/L. The study successfully achieved its objectives of sustainability.
Article
Environmental Sciences
Eleonora Di Salvo, Roberta Tardugno, Vincenzo Nava, Clara Naccari, Antonio Virga, Andrea Salvo, Filomena Corbo, Maria Lisa Clodoveo, Nicola Cicero
Summary: The concentration of mineral elements in 10 different commercially available salts in southern Italy varied according to their type and geographical origin. Some salts showed elevated levels of certain elements such as iron and zinc, which could be beneficial in specific conditions, however, nickel levels were high in certain salts and lead exceeded the maximum level in all samples. Additional monitoring of mineral contents in table salts is recommended for human health.
