Review
Cell Biology
Renjun Gu, Yawen Xia, Pengfei Li, Defang Zou, Keqin Lu, Lang Ren, Hongru Zhang, Zhiguang Sun
Summary: Gastric cancer is a common type of cancer with surgery as the main treatment method. However, it is expensive and painful, and patients often experience recurrence. Ferroptosis, a form of cell death dependent on iron, provides a new perspective in cancer therapy. This review summarizes the latest findings on ferroptosis regulation in gastric cancer, discusses the potential of drugs and genes in inducing ferroptosis for treatment and drug resistance, explores the relationship between ferroptosis and the tumor microenvironment in gastric cancer, and suggests areas for future research to accelerate the clinical utility of ferroptosis induction as a treatment strategy for gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Polymer Science
Urushi Rehman, Mohammed A. S. Abourehab, Amit Alexander, Prashant Kesharwani
Summary: Pancreatic cancer (PC) is a deadly disease with a low 5-year survival rate and is expected to become the second leading cause of cancer-related deaths in the United States by 2030. Treatment options are limited and the tumor microenvironment hinders therapeutic agents. Combining chemotherapeutics using nanoparticle-mediated delivery, such as micelles, shows promise in improving treatment outcomes and reducing side effects.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Oncology
Sin Hye Park, Sang Soo Eom, Hyewon Lee, Bang Wool Eom, Hong Man Yoon, Young-Woo Kim, Keun Won Ryu
Summary: This study aimed to evaluate the effect of vitamin B12 replacement intervals on the clinical characteristics of patients after total gastrectomy. The results showed that regular replacement led to higher vitamin B12 levels, but no significant changes were observed in hemoglobin levels. There was also no significant difference in symptoms between the regular replacement group and the lab-based replacement group.
Article
Chemistry, Medicinal
Xinguang Cao, Rui Li, Huihua Xiong, Jinfang Su, Changqing Guo, Tianqi An, Hong Zong, Ruihua Zhao
Summary: Among the four Pt(IV) complexes, complex 14 shows promising potential in reversing cisplatin resistance and enhancing anticancer efficiency through multiple mechanisms. Its low systematic toxicity makes it a potential novel P-gp-mediated MDR modulator with increased tumor inhibition compared to cisplatin and oxaliplatin.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang
Summary: Gastric cancer is a common malignancy with poor prognosis. Gastric cancer stem cells (GCSCs) are closely associated with drug resistance, recurrence, and metastasis, indicating their potential as therapeutic targets for gastric cancer. However, the relationship and mechanism between GCSCs and gastric cancer still require further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Stefano Ughetto, Cristina Migliore, Filippo Pietrantonio, Maria Apicella, Annalisa Petrelli, Laura D'Errico, Stefania Durando, Daniel Moya-Rull, Sara E. Bellomo, Sabrina Rizzolio, Tania Capeloa, Salvatore Ribisi, Maurizio Degiuli, Rossella Reddavid, Ida Rapa, Uberto Fumagalli, Stefano De Pascale, Dario Ribero, Carla Baronchelli, Giovanni Sgroi, Emanuele Rausa, Gian Luca Baiocchi, Sarah Molfino, Stefania Manenti, Maria Bencivenga, Michele Sacco, Claudia Castelli, Salvatore Siena, Andrea Sartore-Bianchi, Federica Tosi, Federica Morano, Alessandra Raimondi, Michele Prisciandaro, Annunziata Gloghini, Silvia Marsoni, Antonino Sottile, Ivana Sarotto, Anna Sapino, Caterina Marchio, Paola Cassoni, Simonetta Guarrera, Simona Corso, Silvia Giordano
Summary: This study demonstrates that in patients with HER2-amplified gastric cancer, a dual HER2 blockade is crucial for optimal efficacy, leading to complete and durable responses in most cases. A selected subpopulation of HER2-hyper-amplified GC patients could greatly benefit from this treatment strategy.
Article
Medicine, Research & Experimental
Jing Mao, Lipeng Qiu, Lu Ge, Juan Zhou, Qian Ji, Yang Yang, Miaomiao Long, Danhui Wang, Liping Teng, Jinghua Chen
Summary: The KSV micelles can enhance cellular uptake and anticancer effect of the drug, while reducing the toxicity of doxorubicin.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Marie Piantino, Masahiko Nakamoto, Michiya Matsusaki
Summary: Efficient and selective drug delivery systems (DDS) in cancer therapy remain a major challenge. A recent study introduced a molecular block (MB) therapy targeting the cancer cell microenvironment, which induced cancer cell death through self-aggregation and cell membrane disruption. The optimized MB showed increased sensitivity to the cancer microenvironment and avoided off-target accumulation in the bloodstream, making it a promising approach for improved cancer cell targeting.
Review
Oncology
Na Wang, Qingyun Mei, Ziwei Wang, Lu Zhao, Dou Zhang, Dongying Liao, Jinhui Zuo, Hongxia Xie, Yingjie Jia, Fanming Kong
Summary: Gastric cancer is a prevalent and difficult-to-treat malignant tumor. Antibody-drug conjugates hold promise as a novel therapeutic option, but drug resistance is a challenge.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Yu-Ling Bin, Hong-Sai Hu, Feng Tian, Zhen-Hua Wen, Mei-Feng Yang, Ben-Hua Wu, Li-Sheng Wang, Jun Yao, De-Feng Li
Summary: This review summarizes the impact of metabolic reprogramming on the tumor microenvironment and overcoming drug resistance in gastric cancer, and discusses clinical studies on combination treatments with conventional chemotherapy or molecular targeted therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Toru Aoyama, Kentaro Hara, Yukio Maezawa, Keisuke Kazama, Itaru Hashimoto, Sho Sawazaki, Keisuke Komori, Hiroshi Tamagawa, Ayako Tamagawa, Kazuki Kano, Haruhiko Cho, Junya Morita, Kenki Segami, Mie Ishimoto, Takashi Oshima, Norio Yukawa, Yasushi Rino
Summary: The aim of this study was to clarify the clinical course and risk factors for vitamin B12 deficiency after total gastrectomy for gastric cancer patients. The results showed that nearly half of the patients were diagnosed with vitamin B12 deficiency at 6 months after surgery, and postoperative complications and adjuvant chemotherapy were risk factors for vitamin B12 deficiency.
ANTICANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
M. Kathiravan, S. Kavitha, R. Shanthi
Summary: The study reveals that long-term phenytoin treatment significantly impacts the concentration of Folate and Vitamin B12 among epileptic patients, potentially leading to anemia. The mean values of Folate and Vitamin B12 decrease as the duration of phenytoin treatment increases, with significant differences compared to the short-term treatment group.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Multidisciplinary
Dongshi Liang, Meiqian Yu, Shuaishuai Huang, Jinglin Wang, Zijin Xu, Daai Li, Zhongyu Li, Huamin Wang
Summary: This study developed a new approach to address the limitations of magnolol as an anti-tumor agent, by creating an acid-responsive polymeric prodrug that can self-assemble into polymeric micelles. In vitro and in vivo studies showed that these micelles released magnolol selectively at an acidic pH, demonstrated superior inhibition of tumor growth, and had increased accumulation in tumor tissues. Pharmacokinetic analysis also showed a longer half-life and extended duration of action for these prodrugs. These findings indicate the potential of this synthesized prodrug as a promising therapeutic option for gastric cancer.
MATERIALS & DESIGN
(2023)
Review
Oncology
Yue Deng, Sicheng Cai, Jian Shen, Huiming Peng
Summary: Tetraspanins play diverse roles in the progression of gastric cancer, including promoting or inhibiting cell proliferation and invasion, regulating cell motility, and impacting lymph node metastasis. They also have significant clinical implications in therapeutic targeting, drug resistance development, and prognosis prediction for gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Zhifu Gui, Zhenguo Zhao, Qi Sun, Guoyi Shao, Jianming Huang, Wei Zhao, Yuting Kuang
Summary: Long non-coding RNA FEZF1-AS1 is upregulated in gastric cancer tissues and cell lines, and is associated with chemoresistance. High expression of FEZF1-AS1 is an independent predictor for poor overall survival in gastric cancer patients, potentially regulating multi-drug resistance through modulating autophagy in gastric cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yaopeng Qiu, Xinxin Zhang, Xiangqian Deng, Renyi Zhang, Zhen Cai, Zhenzhan Zhang, Hao Liu
Summary: The presence of circulating tumor cell (CTC)-associated white blood cell clusters (CTC-WBC clusters) is associated with poor prognosis in patients with gastric cancer (GC) after radical gastrectomy.
Article
Engineering, Biomedical
Zechan Chen, Junbo Zhuang, Jiadong Pang, Zehao Liu, Penghao Zhang, Haijun Deng, Liming Zhang, Baoxiong Zhuang
Summary: A novel modification for single-walled carbon nanotubes (SWNTs) with amylose derivatives containing poly(L-lysine) dendrons (ADP@SWNT) is developed in this study. The ADP@SWNT complex exhibits good water dispersion stability and pDNA transfection capacity. It has been demonstrated to inhibit tumor growth and metastasis both in vitro and in vivo, and the anti-tumor effect can be enhanced by near-infrared irradiation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Medicine, Research & Experimental
Tao Chen, Xunjun Li, Qingyi Mao, Yiyun Wang, Hanyi Li, Chen Wang, Yuyang Shen, Erjia Guo, Qinglie He, Jie Tian, Mansheng Zhu, Jing Wu, Weiqi Liang, Hao Liu, Jiang Yu, Guoxin Li
Summary: This study developed a model based on ImmunoScore and Radiomic ImmunoScore to assess the tumor microenvironment (TME), predict prognosis, and determine the benefits of adjuvant chemotherapy in gastric cancer (GC) patients. The model outperformed the traditional TNM staging system.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Surgery
Changming Huang, Hao Liu, Yanfeng Hu, Yihong Sun, Xiangqian Su, Hui Cao, Jiankun Hu, Kuan Wang, Jian Suo, Kaixiong Tao, Xianli He, Hongbo Wei, Mingang Ying, Weiguo Hu, Xiaohui Du, Jiang Yu, Chaohui Zheng, Fenglin Liu, Ziyu Li, Gang Zhao, Jiachen Zhang, Pingyan Chen, Guoxin Li
Summary: The study found that laparoscopic distal gastrectomy with D2 lymphadenectomy performed by experienced surgeons in high-volume specialized institutions resulted in similar 5-year overall survival compared with open distal gastrectomy among patients with locally advanced gastric cancer. This randomized clinical trial reports 5-year overall survival data from the CLASS-01 trial of laparoscopic vs open distal gastrectomy among patients with locally advanced gastric cancer.
Article
Pharmacology & Pharmacy
Huikang Yang, Nianhua Wang, Ruimeng Yang, Liming Zhang, Xinqing Jiang
Summary: Folic acid-decorated reduction-sensitive star polymeric nanoparticles were synthesized and used for tumor-targeted MRI and chemotherapy. The nanoparticles efficiently delivered drugs and superparamagnetic iron oxide particles into tumor cells through folate receptor-mediated endocytosis and disulfide bond cleavage.
Article
Multidisciplinary Sciences
Chaoping Fu, Weisen Huang, Xiaochang Lu, Shibin Wang, Liming Zhang, Aizheng Chen
Summary: Hydrogels are highly dense polymeric structures with softness, elasticity, and high water content, resembling biological tissues. Self-healing hydrogels that can prolong their life and improve durability, reliability, and safety have been designed. They can be classified into physical and chemical hydrogels based on the interactions between polymer chains. Physical hydrogels rely on non-covalent interactions, while chemical hydrogels rely on reversible covalent interactions.
CHINESE SCIENCE BULLETIN-CHINESE
(2022)
Article
Oncology
Chen Xinhua, Lin Tian, Huang Huilin, Zhao Mingli, Chen Tao, Chen Hao, Mai Jinsheng, Zhong Qinglei, Liu Hao, Zhao Liying, Hu Yanfeng, Li Guoxin, Yu Jiang
Summary: This study demonstrates that OGT-assisted overlap esophagojejunostomy is safe and feasible for patients with G/GEJ tumors, with good short-term outcomes.
Article
Immunology
Xinhua Chen, Huimin Zhang, Minghao Wang, Hao Liu, Yanfeng Hu, Tian Lin, Hao Chen, Mingli Zhao, Tao Chen, Guoxin Li, Jiang Yu, Liying Zhao
Summary: The study confirmed intratumoral heterogeneity of PD-L1 expression in gastric cancer and identified age, Ki-67 index, and Lauren classification as potential biomarkers for predicting the efficacy of anti-PD-1 therapy in GC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Weicai Huang, Zhen Han, Zepang Sun, Hao Feng, Liying Zhao, Qingyu Yuan, Chuanli Chen, Shitong Yu, Yanfeng Hu, Jiang Yu, Hao Liu, Guoxin Li, Yuming Jiang
Summary: The study identifies PAK6 as an important regulator of the DNA damage response (DDR) and chemoresistance in gastric cancer (GC). PAK6 enhances homologous recombination (HR) to facilitate DNA double-strand break repair, leading to chemoresistance. These findings provide insights for reversing chemoresistance in clinical decision-making.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Zhenzhan Zhang, Binshu Weng, Yaopeng Qiu, Hao Feng, Renyi Zhang, Jiachen Zhang, Yanfeng Hu, Jiang Yu, Guoxin Li, Hao Liu
Summary: The study found that perioperative serum interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF alpha) levels are negatively associated with 5-year survival outcomes in locally advanced gastric cancer patients, indicating the potential survival benefits from perioperative anti-inflammatory treatment.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Chaorui Wu, Yaopeng Qiu, Renyi Zhang, Xiaoqing Li, Huayuan Liang, Minghao Wang, Fengping Li, Mansheng Zhu, Gengtai Ye, Hao Liu, Guoxin Li, Liying Zhao
Summary: This study retrospectively analyzed the association between baseline peripheral basophils and clinical outcomes in gastric cancer patients treated with anti-PD-1 plus chemotherapy. The study found that peripheral basophil count could be a potential biomarker for predicting the efficacy of anti-PD-1 treatment in advanced gastric cancer. The study also revealed that basophils may induce an immune-evasive tumor microenvironment by increasing M2 macrophage infiltration.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Weicai Huang, Yuming Jiang, Wenjun Xiong, Zepang Sun, Chuanli Chen, Qingyu Yuan, Kangneng Zhou, Zhen Han, Hao Feng, Hao Chen, Xiaokun Liang, Shitong Yu, Yanfeng Hu, Jiang Yu, Yan Chen, Liying Zhao, Hao Liu, Zhiwei Zhou, Wei Wang, Yikai Xu, Guoxin Li
Summary: In this study, the authors used CT-based radiomics to predict the response to immunotherapy in gastric cancer patients, and found that radiomics imaging biomarker is closely associated with tumor immune microenvironment and may correlate with prognosis and response to anti PD-1 immunotherapy.
NATURE COMMUNICATIONS
(2022)
Article
Surgery
Xunjun Li, Zhongya Zhai, Wenfu Ding, Li Chen, Yuyun Zhao, Wenjun Xiong, Yunfei Zhang, Dingyi Lin, Zequn Chen, Wei Wang, Yongshun Gao, Shirong Cai, Jiang Yu, Xinhua Zhang, Hao Liu, Guoxin Li, Tao Chen
Summary: This study developed a support vector machine model to predict overall survival (OS) and disease-free survival (DFS) in gastric cancer patients. It also assessed the benefit of adjuvant chemotherapy for TNM stage II and III patients. The model showed better performance than the TNM staging system and successfully identified low, moderate, and high-risk patients.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Biochemical Research Methods
Heng-Cong Luo, Kai-Jin Mai, En Liu, Hui Chen, Yi-Juan Xie, Yong-Xiong Zheng, Rong Lin, Li-Ming Zhang, Ying Zhang
Summary: This study demonstrates the potential of a Dextran-PAMAM/siMMP-9 complex as a gene carrier for downregulating MMP-9 expression in diabetic foot ulcers. The complex effectively accelerated wound healing in diabetic rat models, indicating its promising regenerative capabilities for improving DFU healing.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Medicine, General & Internal
Xinhua Chen, Yuehong Chen, Tao Li, Weiqi Liang, Huilin Huang, Hongtao Su, Chuyang Sui, Yanfeng Hu, Hao Chen, Tian Lin, Tao Chen, Liying Zhao, Hao Liu, Guoxin Li, Jiang Yu
Summary: This study reveals that diabetes mellitus (DM) is an independent risk factor for promoting lymph node (LN) metastasis in gastric cancer (GC). The presence of DM is associated with more advanced LN metastasis and higher number of metastatic LN. The severity of LN involvement increases with the advancement of primary tumor depth.
CHINESE MEDICAL JOURNAL
(2022)
