Cubosome nanoparticles for enhanced delivery of mitochondria anticancer drug elesclomol and therapeutic monitoring via sub-cellular NAD(P)H multi-photon fluorescence lifetime imaging

Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD

(2018) Olivia I. Kolenc et al.   ANTIOXIDANTS & REDOX SIGNALING

Applications of fluorescence lifetime imaging in clinical medicine

(2018) Zhanwen Wang et al.   Journal of Innovative Optical Health Sciences

Time-resolved fluorescence microscopy (FLIM) as an analytical tool in skin nanomedicine

(2017) Ulrike Alexiev et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

ROS-modulated therapeutic approaches in cancer treatment

(2017) Muhammad Hassan Raza et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Self-assembled Lyotropic Liquid Crystalline Phase Behavior of Monoolein–Capric Acid–Phospholipid Nanoparticulate Systems

(2017) Jiali Zhai et al.   LANGMUIR

DiAna, an ImageJ tool for object-based 3D co-localization and distance analysis

(2017) Jean-François Gilles et al.   METHODS

The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo

(2017) Ye Liu et al.   Small

Chemotherapy with cisplatin: insights into intracellular pH and metabolic landscape of cancer cells in vitro and in vivo

(2017) Marina V. Shirmanova et al.   Scientific Reports

Investigation of Mitochondrial Metabolic Response to Doxorubicin in Prostate Cancer Cells: An NADH, FAD and Tryptophan FLIM Assay

(2017) Shagufta Rehman Alam et al.   Scientific Reports

Lipidic Cubic-Phase Nanoparticles-Cubosomes for Efficient Drug Delivery to Cancer Cells

(2017) Ewa Nazaruk et al.   ChemPlusChem

Imaging Reactive Oxygen Species-Induced Modifications in Living Systems

(2016) Giuseppe Maulucci et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidation of NADH and ROS production by respiratory complex I

(2016) Andrei D. Vinogradov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cubosomes: remarkable drug delivery potential

(2016) Zahra Karami et al.   DRUG DISCOVERY TODAY

Amphiphilic brush polymers produced using the RAFT polymerisation method stabilise and reduce the cell cytotoxicity of lipid lyotropic liquid crystalline nanoparticles

(2016) Jiali Zhai et al.   FARADAY DISCUSSIONS

Investigating mitochondrial redox state using NADH and NADPH autofluorescence

(2016) Thomas S. Blacker et al.   FREE RADICAL BIOLOGY AND MEDICINE

A phase I study of elesclomol sodium in patients with acute myeloid leukemia

(2016) David Hedley et al.   LEUKEMIA & LYMPHOMA

Amphiphilic brush polymers produced using the RAFT polymerisation method stabilise and reduce the cell cytotoxicity of lipid lyotropic liquid crystalline nanoparticles

(2016) Jiali Zhai et al.   FARADAY DISCUSSIONS

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Cupreous Complex-Loaded Chitosan Nanoparticles for Photothermal Therapy and Chemotherapy of Oral Epithelial Carcinoma

(2015) Min Lin et al.   ACS Applied Materials & Interfaces

Physical Principles of Nanoparticle Cellular Endocytosis

(2015) Sulin Zhang et al.   ACS Nano

Stealth monoolein-based nanocarriers for delivery of siRNA to cancer cells

(2015) Ana C.N. Oliveira et al.   Acta Biomaterialia

Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II)

(2015) Brian B. Hasinoff et al.   BIOCHEMICAL PHARMACOLOGY

Monoolein-based cubosomes affect lipid profile in HeLa cells

(2015) Antonella Rosa et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents

(2015) Josephine Modica-Napolitano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Direct visualization of dispersed lipid bicontinuous cubic phases by cryo-electron tomography

(2015) Davide Demurtas et al.   Nature Communications

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells

(2015) Angela Maria Falchi et al.   Toxicology Research

In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment

(2015) Amy T. Shah et al.   NEOPLASIA

In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting

(2015) Mohamed Nasr et al.   Acta Pharmaceutica Sinica B

Versatile RNA Interference Nanoplatform for Systemic Delivery of RNAs

(2014) Ki Young Choi et al.   ACS Nano

Quantitative Optical Imaging of Primary Tumor Organoid Metabolism Predicts Drug Response in Breast Cancer

(2014) A. J. Walsh et al.   CANCER RESEARCH

The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II)

(2014) Brian B. Hasinoff et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM

(2014) Thomas S. Blacker et al.   Nature Communications

Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II)

(2013) Arun A. Yadav et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Characterization of cisplatin-loaded cubosomes and hexosomes: Effect of mixing with human plasma

(2013) I.D. Mat Azmi et al.   Journal of Geriatric Oncology

Bicontinuous cubic phase nanoparticle lipid chemistry affects toxicity in cultured cells

(2013) Tracey M. Hinton et al.   Toxicology Research

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

(2012) Masazumi Nagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disposition and association of the steric stabilizer Pluronic® F127 in lyotropic liquid crystalline nanostructured particle dispersions

(2012) Adam J. Tilley et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol

(2012) Ronald K. Blackman et al.   PLoS One

Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays

(2012) Sephra N. Rampersad   SENSORS

Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines

(2011) S.B. Rizwan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Time-Correlated Single Photon Counting For Simultaneous Monitoring Of Zinc Oxide Nanoparticles And NAD(P)H In Intact And Barrier-Disrupted Volunteer Skin

(2011) Lynlee L. Lin et al.   PHARMACEUTICAL RESEARCH

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Monoolein: a magic lipid?

(2010) Chandrashekhar V. Kulkarni et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Phase II, Randomized, Controlled, Double-Blinded Trial of Weekly Elesclomol Plus Paclitaxel Versus Paclitaxel Alone for Stage IV Metastatic Melanoma

(2009) Steven O'Day et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization and potential applications of nanostructured aqueous dispersions

(2008) Anan Yaghmur et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Elesclomol induces cancer cell apoptosis through oxidative stress

(2008) J. R. Kirshner et al.   MOLECULAR CANCER THERAPEUTICS

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING

Effect of Copper Sulfate on Performance of a Serum-Free CHO Cell Culture Process and the Level of Free Thiol in the Recombinant Antibody Expressed

(2005) Wendy B. Chaderjian et al.   BIOTECHNOLOGY PROGRESS