Activation of mGluR1 Mediates C1q-Dependent Microglial Phagocytosis of Glutamatergic Synapses in Alzheimer’s Rodent Models

Amyloid fibrils induce dysfunction of hippocampal glutamatergic silent synapses

(2018) Bihua Bie et al.   HIPPOCAMPUS

Activation of CB 2 receptor system restores cognitive capacity and hippocampal Sox2 expression in a transgenic mouse model of Alzheimer's disease

(2017) Jiang Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in Rats

(2016) Jiang Wu et al.   ANESTHESIOLOGY

Late age increase in soluble amyloid-beta levels in the APP23 mouse model despite steady-state levels of amyloid-beta-producing proteins

(2016) Leen Janssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model

(2016) Carla M. Yuede et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

(2016) Olga Kokiko-Cochran et al.   JOURNAL OF NEUROTRAUMA

Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins

(2016) Keiko Matsuda et al.   NEURON

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome

(2016) Yue Li et al.   Science Translational Medicine

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus

(2015) Iliana Michailidou et al.   ANNALS OF NEUROLOGY

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of theFmr1Knockout Mouse Model of Fragile X Syndrome

(2015) Henry G. S. Martin et al.   CEREBRAL CORTEX

Closed Head Injury in an Age-Related Alzheimer Mouse Model Leads to an Altered Neuroinflammatory Response and Persistent Cognitive Impairment

(2015) S. J. Webster et al.   JOURNAL OF NEUROSCIENCE

Inflammatory cascades mediate synapse elimination in spinal cord compression

(2014) Morito Takano et al.   Journal of Neuroinflammation

Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse

(2014) S H Kim et al.   MOLECULAR PSYCHIATRY

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

(2014) Gonzalo Viana Di Prisco et al.   NATURE NEUROSCIENCE

Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency

(2014) Bihua Bie et al.   NATURE NEUROSCIENCE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Microglial CR3 Activation Triggers Long-Term Synaptic Depression in the Hippocampus via NADPH Oxidase

(2014) Jingfei Zhang et al.   NEURON

Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease

(2014) Alison Hamilton et al.   Molecular Brain

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

(2013) Dorothy P. Schafer et al.   CURRENT OPINION IN NEUROBIOLOGY

Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease

(2013) Valeriy G. Ostapchenko et al.   JOURNAL OF NEUROCHEMISTRY

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

(2013) A. H. Stephan et al.   JOURNAL OF NEUROSCIENCE

The Terminal Pathway of the Complement System Is Activated in Focal Penetrating But Not in Mild Diffuse Traumatic Brain Injury

(2013) Elham Rostami et al.   JOURNAL OF NEUROTRAUMA

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency

(2013) Jiang Wu et al.   NEUROBIOLOGY OF AGING

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3

(2013) X. Chen et al.   NEUROSCIENCE

Early Enriched Environment Exposure Protects Spatial Memory and Accelerates Amyloid Plaque Formation in APPSwe/PS1L166P Mice

(2013) Francesca Montarolo et al.   PLoS One

Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy

(2013) Z. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency

(2012) Jiang Wu et al.   NEUROBIOLOGY OF AGING

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

β-Amyloid Peptide Variants in Brains and Cerebrospinal Fluid from Amyloid Precursor Protein (APP) Transgenic Mice

(2011) Heinke Schieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links

(2011) D. K. Sokol et al.   NEUROLOGY

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Increased synaptic GluR1 subunits in the anterior cingulate cortex of rats with peripheral inflammation

(2010) Bihua Bie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nerve Growth Factor-Regulated Emergence of Functional  -Opioid Receptors

(2010) B. Bie et al.   JOURNAL OF NEUROSCIENCE

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies

(2010) Eun Kyung Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease

(2010) T. Ahmed et al.   NEUROSCIENCE

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatially restricting gene expression by local translation at synapses

(2010) Dan Ohtan Wang et al.   TRENDS IN NEUROSCIENCES

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

(2009) Binggui Sun et al.   Cell Stem Cell

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Rewarding Morphine-Induced Synaptic Function of  -Opioid Receptors on Central Glutamate Synapses

(2009) B. Bie et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Ethanol-induced delta-opioid receptor modulation of glutamate synaptic transmission and conditioned place preference in central amygdala

(2009) B. Bie et al.   NEUROSCIENCE

Synapse- and Stimulus-Specific Local Translation During Long-Term Neuronal Plasticity

(2009) D. O. Wang et al.   SCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis

(2008) Arturas Volianskis et al.   NEUROBIOLOGY OF AGING

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

(2008) Gary J. Bassell et al.   NEURON

Metabotropic Glutamate Receptors and Fragile X Mental Retardation Protein: Partners in Translational Regulation at the Synapse

(2008) J. A. Ronesi et al.   Science Signaling