Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress

DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex

(2018) Nathalia Varejão et al.   EMBO JOURNAL

Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase

(2017) Michael C. Reubens et al.   MOLECULAR AND CELLULAR BIOLOGY

Specialized interfaces of Smc5/6 control hinge stability and DNA association

(2017) Aaron Alt et al.   Nature Communications

SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion

(2017) Minghua Nie et al.   PLoS Genetics

Multi-BRCT scaffolds use distinct strategies to support genome maintenance

(2016) Bingbing Wan et al.   CELL CYCLE

Rtt107 BRCT domains act as a targeting module in the DNA damage response

(2016) Grace P. Leung et al.   DNA REPAIR

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

SMC complexes: from DNA to chromosomes

(2016) Frank Uhlmann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Rtt107 BRCT scaffold and its partner modification enzymes collaborate to promote replication

(2016) Lisa Hang et al.   Nucleus

Non-Smc element 5 (Nse5) of the Smc5/6 complex interacts with SUMO pathway components

(2016) Denise E. Bustard et al.   Biology Open

The Rtt107 BRCT scaffold and its partner modification enzymes collaborate to promote replication

(2016) Lisa Hang et al.   Nucleus

Resolving complex chromosome structures during meiosis: versatile deployment of Smc5/6

(2015) Dideke E. Verver et al.   CHROMOSOMA

Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA

(2015) Katerina Zabrady et al.   NUCLEIC ACIDS RESEARCH

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

The Smc5/6 Complex Is an ATP-Dependent Intermolecular DNA Linker

(2015) Takaharu Kanno et al.   Cell Reports

Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants

(2015) Arancha Sánchez et al.   G3-Genes Genomes Genetics

A Novel Histone Deacetylase Complex in the Control of Transcription and Genome Stability

(2014) N. Zilio et al.   MOLECULAR AND CELLULAR BIOLOGY

A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks

(2013) Yang Yu et al.   DNA REPAIR

 H2A-Binding Protein Brc1 Affects Centromere Function in Fission Yeast

(2013) S. Y. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Smc5/6 Coordinates Formation and Resolution of Joint Molecules with Chromosome Morphology to Ensure Meiotic Divisions

(2013) Alice Copsey et al.   PLoS Genetics

Smc5/6-Mms21 Prevents and Eliminates Inappropriate Recombination Intermediates in Meiosis

(2013) Martin Xaver et al.   PLoS Genetics

Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair

(2012) Xinxin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplex

(2012) S. Wehrkamp-Richter et al.   NUCLEIC ACIDS RESEARCH

RAD18–BRCTx interaction is required for efficient repair of UV-induced DNA damage

(2011) Ting Liu et al.   DNA REPAIR

Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway

(2011) Wei Yan et al.   FEBS LETTERS

Rtt107 Is Required for Recruitment of the SMC5/6 Complex to DNA Double Strand Breaks

(2011) Grace P. Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation

(2011) I. Chung et al.   JOURNAL OF CELL SCIENCE

DNA Repair and Global Sumoylation Are Regulated by Distinct Ubc9 Noncovalent Complexes

(2011) J. Prudden et al.   MOLECULAR AND CELLULAR BIOLOGY

Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes

(2011) Claudia Tapia-Alveal et al.   MOLECULAR BIOLOGY OF THE CELL

γH2A binds Brc1 to maintain genome integrity during S-phase

(2010) Jessica S Williams et al.   EMBO JOURNAL

The Smc5/6 Complex and Esc2 Influence Multiple Replication-associated Recombination Processes in Saccharomyces cerevisiae

(2010) Koyi Choi et al.   MOLECULAR BIOLOGY OF THE CELL

DNA Damage Signaling Recruits the Rtt107-Slx4 Scaffolds via Dpb11 to Mediate Replication Stress Response

(2010) Patrice Y. Ohouo et al.   MOLECULAR CELL

The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages

(2010) M. Bermudez-Lopez et al.   NUCLEIC ACIDS RESEARCH

Smc5/6 maintains stalled replication forks in a recombination-competent conformation

(2009) Anja Irmisch et al.   EMBO JOURNAL

Smc5-Smc6-Dependent Removal of Cohesin from Mitotic Chromosomes

(2009) E. A. Outwin et al.   MOLECULAR AND CELLULAR BIOLOGY

Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively

(2008) Stephanie Pebernard et al.   EMBO JOURNAL

Nse1 RING-like Domain Supports Functions of the Smc5-Smc6 Holocomplex in Genome Stability

(2008) Stephanie Pebernard et al.   MOLECULAR BIOLOGY OF THE CELL