Targeting primary Sjögren’s syndrome

Short-term and low-dose IL-2 therapy restores the Th17/Treg balance in the peripheral blood of patients with primary Sjögren’s syndrome

(2018) Miao Miao et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased proportion of a CD38 high IgD + B cell subset in peripheral blood is associated with clinical and immunological features in patients with primary Sjögren's syndrome

(2018) Eriko Ishioka-Takei et al.   CLINICAL IMMUNOLOGY

The tolerogenic peptide hCDR1 immunomodulates cytokine and regulatory molecule gene expression in blood mononuclear cells of primary Sjogren's syndrome patients

(2018) Zev Sthoeger et al.   CLINICAL IMMUNOLOGY

Role of the IL-12/IL-35 balance in patients with Sjögren syndrome

(2018) Olivier Fogel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Systemic activation of NLRP3 inflammasome in patients with severe primary Sjögren's syndrome fueled by inflammagenic DNA accumulations

(2018) Aigli G. Vakrakou et al.   JOURNAL OF AUTOIMMUNITY

TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis

(2018) Iris L.A. Bodewes et al.   JOURNAL OF AUTOIMMUNITY

Clinical practice guideline for Sjögren’s syndrome 2017

(2018) Takayuki Sumida et al.   Modern Rheumatology

Primary Sjögren’s Syndrome

(2018) Xavier Mariette et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ectopic germinal centre-like structures in minor salivary gland biopsy predict lymphoma occurrence in patients with primary Sjögren syndrome

(2018) Damien Sène et al.   Arthritis & Rheumatology

Anti-calponin-3 autoantibodies: a new specificity in patients with Sjögren's syndrome

(2018) Julius Birnbaum et al.   Arthritis & Rheumatology

Janus kinase 1 inhibition suppresses interferon-induced B cell activating factor production in human salivary gland: potential therapeutic strategy for primary Sjögren's syndrome

(2018) Jaeseon Lee et al.   Arthritis & Rheumatology

Efficacy of Epratuzumab, an Anti-CD22 Monoclonal IgG Antibody, in Systemic Lupus Erythematosus Patients With Associated Sjögren's Syndrome

(2018) Jacques-Eric Gottenberg et al.   Arthritis & Rheumatology

Clinical Efficacy and Safety of Baminercept, a Lymphotoxin β Receptor Fusion Protein, in Primary Sjögren's Syndrome

(2018) E. William St.Clair et al.   Arthritis & Rheumatology

Effect of bone morphogenetic protein 6 on immunomodulatory functions of salivary gland-derived mesenchymal stem cells in Sjögren’s Syndrome

(2018) Junji Xu et al.   STEM CELLS AND DEVELOPMENT

IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjögren’s Syndrome Patients

(2018) Jing Luo et al.   Frontiers in Immunology

Correction of Ductal CFTR Activity Rescues Acinar Cell and Pancreatic and Salivary Gland Functions in Mouse Models of Autoimmune Disease

(2017) Mei Zeng et al.   GASTROENTEROLOGY

P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy

(2017) Mahmoud G. Khalafalla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human regulatory B cells in health and disease: therapeutic potential

(2017) Claudia Mauri et al.   JOURNAL OF CLINICAL INVESTIGATION

The P2X7 receptor-NLRP3 inflammasome complex predicts the development of non-Hodgkin's lymphoma in Sjogren's syndrome: a prospective, observational, single-centre study

(2017) C. Baldini et al.   JOURNAL OF INTERNAL MEDICINE

Pathogenic role of endogenous TNF-α in the development of Sjögren’s-like sialadenitis and secretory dysfunction in non-obese diabetic mice

(2017) Jing Zhou et al.   LABORATORY INVESTIGATION

Diffusion-weighted magnetic resonance imaging of parotid glands before and after abatacept therapy in patients with Sjögren’s syndrome associated with rheumatoid arthritis: Utility to evaluate and predict response to treatment

(2017) Hiroyuki Takahashi et al.   Modern Rheumatology

Anti-Ro52 antibody level is an important marker of fetal congenital heart block risk in anti-Ro/SSA antibody positive pregnancy

(2017) Mai Miyasato-Isoda et al.   Modern Rheumatology

Ectopic lymphoid neogenesis in rheumatic autoimmune diseases

(2017) Michele Bombardieri et al.   Nature Reviews Rheumatology

Editorial: Rituximab in the Treatment of Sjögren's Syndrome: Is It the Right or Wrong Drug?

(2017) Hendrika Bootsma et al.   Arthritis & Rheumatology

Increased CCL25 and T Helper Cells Expressing CCR9 in the Salivary Glands of Patients With Primary Sjögren's Syndrome: Potential New Axis in Lymphoid Neogenesis

(2017) Sofie L. M. Blokland et al.   Arthritis & Rheumatology

Enhanced Bruton's Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease

(2017) Odilia B. J. Corneth et al.   Arthritis & Rheumatology

Randomized Controlled Trial of Rituximab and Cost-Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjögren's Syndrome

(2017) Simon J. Bowman et al.   Arthritis & Rheumatology

Attenuation of Follicular Helper T Cell-Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjögren's Syndrome

(2017) Gwenny M. Verstappen et al.   Arthritis & Rheumatology

Towards personalised treatment in primary Sjögren's syndrome: baseline parotid histopathology predicts responsiveness to rituximab treatment

(2016) Konstantina Delli et al.   ANNALS OF THE RHEUMATIC DISEASES

2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome

(2016) Caroline H Shiboski et al.   ANNALS OF THE RHEUMATIC DISEASES

RORγt antagonist suppresses M3 muscarinic acetylcholine receptor-induced Sjögren's syndrome-like sialadenitis

(2016) M. Tahara et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytokine-induced STAT1 activation is increased in patients with primary Sjögren's syndrome

(2016) Marja Pertovaara et al.   CLINICAL IMMUNOLOGY

Central role for marginal zone B cells in an animal model of Sjogren's syndrome

(2016) Long Shen et al.   CLINICAL IMMUNOLOGY

Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction

(2016) I Alevizos et al.   GENE THERAPY

New Murine Model of Early Onset Autoimmune Thyroid Disease/Hypothyroidism and Autoimmune Exocrinopathy of the Salivary Gland

(2016) Timothy Daniel Kayes et al.   JOURNAL OF IMMUNOLOGY

B Cell Depletion Therapy Normalizes Circulating Follicular Th Cells in Primary Sjögren Syndrome

(2016) Gwenny M. Verstappen et al.   JOURNAL OF RHEUMATOLOGY

Safety, pharmacokinetics, and pharmacodynamics of RSLV-132, an RNase-Fc fusion protein in systemic lupus erythematosus: a randomized, double-blind, placebo-controlled study

(2016) D J Burge et al.   LUPUS

Cryoglobulinemic vasculitis with primary Sjögren’s syndrome: A case report

(2016) Jumpei Hasegawa et al.   Modern Rheumatology

Effectiveness and safety of tocilizumab in achieving clinical and functional remission, and sustaining efficacy in biologics-naive patients with rheumatoid arthritis: The FIRST Bio study

(2016) Naoki Ishiguro et al.   Modern Rheumatology

Association of plasmacytoid dendritic cells with B cell infiltration in minor salivary glands in patients with Sjögren's syndrome

(2016) Jidong Zhao et al.   Modern Rheumatology

Effectiveness of abatacept for patients with Sjögren’s syndrome associated with rheumatoid arthritis. An open label, multicenter, one-year, prospective study: ROSE (Rheumatoid Arthritis with Orencia Trial toward Sjögren’s syndrome Endocrinopathy) trial

(2016) Hiroto Tsuboi et al.   Modern Rheumatology

Aquaporin gene therapy corrects Sjögren’s syndrome phenotype in mice

(2016) Zhennan Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoantibodies in Sjögren’s Syndrome

(2016) Anum Fayyaz et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Sexual dimorphic function of IL-17 in salivary gland dysfunction of the C57BL/6.NOD-Aec1Aec2 model of Sjögren’s syndrome

(2016) Alexandria Voigt et al.   Scientific Reports

2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts

(2016) Caroline H. Shiboski et al.   Arthritis & Rheumatology

A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjögren's syndrome and systemic lupus erythematosus

(2015) K. Szabó et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-6 inhibits apoptosis of exocrine gland tissues under inflammatory conditions

(2015) Jing Zhou et al.   CYTOKINE

High circulating level of interleukin-18 in patients with primary Sjögren's syndrome is associated with disease activity

(2015) Yan Chen et al.   Modern Rheumatology

Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease

(2015) Joseph Tauber et al.   OPHTHALMOLOGY

Brief Report: Ultrasonographic Assessment of Salivary Gland Response to Rituximab in Primary Sjögren's Syndrome

(2015) Sandrine Jousse-Joulin et al.   Arthritis & Rheumatology

Molecular Subsetting of Interferon Pathways in Sjögren's Syndrome

(2015) John C. Hall et al.   Arthritis & Rheumatology

CXCL13 and CCL11 Serum Levels and Lymphoma and Disease Activity in Primary Sjögren's Syndrome

(2015) G. Nocturne et al.   Arthritis & Rheumatology

Prediction of Sjögren's Syndrome Years Before Diagnosis and Identification of Patients With Early Onset and Severe Disease Course by Autoantibody Profiling

(2015) Elke Theander et al.   Arthritis & Rheumatology

Treatment of Primary Sjögren Syndrome With Rituximab

(2014) Valérie Devauchelle-Pensec et al.   ANNALS OF INTERNAL MEDICINE

Abatacept treatment reduces disease activity in early primary Sjögren's syndrome (open-label proof of concept ASAP study)

(2014) P M Meiners et al.   ANNALS OF THE RHEUMATIC DISEASES

Epidemiology of primary Sjögren's syndrome: a systematic review and meta-analysis

(2014) Baodong Qin et al.   ANNALS OF THE RHEUMATIC DISEASES

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Effects of Hydroxychloroquine on Symptomatic Improvement in Primary Sjögren Syndrome

(2014) Jacques-Eric Gottenberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Differentiation of follicular helper T cells by salivary gland epithelial cells in primary Sjögren's syndrome

(2014) Ya-Zhuo Gong et al.   JOURNAL OF AUTOIMMUNITY

IL-17–induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs

(2014) Henrike Fleige et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of IL-18 and Th17 Cells in Salivary Glands of Patients with Sjogren's Syndrome, and Amplification of IL-17-Mediated Secretion of Inflammatory Cytokines from Salivary Gland Cells by IL-18

(2014) A. Sakai et al.   JOURNAL OF IMMUNOLOGY

CXCL13, CCL21, and CXCL12 Expression in Salivary Glands of Patients with Sjogren's Syndrome and MALT Lymphoma: Association with Reactive and Malignant Areas of Lymphoid Organization

(2014) F. Barone et al.   JOURNAL OF IMMUNOLOGY

IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage

(2014) G. L. Stritesky et al.   JOURNAL OF IMMUNOLOGY

A Crucial Role of RORγt in the Development of Spontaneous Sialadenitis-like Sjögren’s Syndrome

(2014) Mana Iizuka et al.   JOURNAL OF IMMUNOLOGY

Inhibition of PI3Kδ Reduces Kidney Infiltration by Macrophages and Ameliorates Systemic Lupus in the Mouse

(2014) Abel Suárez-Fueyo et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of rebamipide for the treatment of dry mouth symptoms in patients with Sjögren’s syndrome: a double-blind placebo-controlled multicenter trial

(2014) Susumu Sugai et al.   Modern Rheumatology

Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren’s syndrome

(2014) Takayuki Sumida et al.   Modern Rheumatology

Efficacy and safety of abatacept for patients with Sjögren's syndrome associated with rheumatoid arthritis: Rheumatoid Arthritis with Orencia Trial toward Sjögren's syndrome Endocrinopathy (ROSE) trial—an open-label, one-year, prospective study—Interim analysis of 32 patients for 24 weeks

(2014) Hiroto Tsuboi et al.   Modern Rheumatology

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

(2014) Ren-Xi Wang et al.   NATURE MEDICINE

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjo¨gren׳s syndrome? Association between clinical, histopathological, and molecular features: A retrospective study

(2014) Francesco Carubbi et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Primary Sjögren's Syndrome Is Characterized by Distinct Phenotypic and Transcriptional Profiles of IgD+ Unswitched Memory B Cells

(2014) Mustimbo E. P. Roberts et al.   Arthritis & Rheumatology

Tear Cathepsin S as a Candidate Biomarker for Sjögren's Syndrome

(2014) Sarah F. Hamm-Alvarez et al.   Arthritis & Rheumatology

The efficacy of topical 0.05 % cyclosporine A in patients with dry eye disease associated with Sjögren’s syndrome

(2014) Hülya Devecı et al.   INTERNATIONAL OPHTHALMOLOGY

Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase II study

(2013) Xavier Mariette et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study

(2013) Daniel J Wallace et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of Bone Morphogenetic Protein 6 With Exocrine Gland Dysfunction in Patients With Sjögren's Syndrome and in Mice

(2013) Hongen Yin et al.   ARTHRITIS AND RHEUMATISM

Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome

(2013) Krisztina Szabo et al.   CLINICAL IMMUNOLOGY

Targeting IL-1 in Sjögren's syndrome

(2013) Akiko Yamada et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Degrading View of Regulatory T Cells

(2013) Arian Laurence et al.   IMMUNITY

Epigenetic dysregulation in salivary glands from patients with primary Sjögren's syndrome may be ascribed to infiltrating B cells

(2013) Yosra Thabet et al.   JOURNAL OF AUTOIMMUNITY

The P2X7receptor-inflammasome complex has a role in modulating the inflammatory response in primary Sjögren's syndrome

(2013) C. Baldini et al.   JOURNAL OF INTERNAL MEDICINE

Diagnostic accuracy of anti-alpha-fodrin antibodies for primary Sjögren's syndrome

(2013) Qin Qin et al.   Modern Rheumatology

Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan

(2013) Hiroto Tsuboi et al.   Modern Rheumatology

Neuromyelitis optica spectrum disorder complicated with Sjogren syndrome successfully treated with tocilizumab: A case report

(2013) Toshihiko Komai et al.   Modern Rheumatology

Targeting the Splicing of mRNA in Autoimmune Diseases: BAFF Inhibition in Sjögren's Syndrome as a Proof of Concept

(2013) N. Roescher et al.   MOLECULAR THERAPY

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

(2013) Christopher J Lessard et al.   NATURE GENETICS

Serum Levels of Beta2-Microglobulin and Free Light Chains of Immunoglobulins Are Associated with Systemic Disease Activity in Primary Sjögren’s Syndrome. Data at Enrollment in the Prospective ASSESS Cohort

(2013) Jacques-Eric Gottenberg et al.   PLoS One

Evaluation of Histologic, Serologic, and Clinical Changes in Response to Abatacept Treatment of Primary Sjögren's Syndrome: A Pilot Study

(2013) Sabine Adler et al.   ARTHRITIS CARE & RESEARCH

Efficacy and safety of rituximab treatment in early primary Sjögren's syndrome: a prospective, multi-center, follow-up study

(2013) Francesco Carubbi et al.   ARTHRITIS RESEARCH & THERAPY

PI3 Kinase δ Is a Key Regulator of Synoviocyte Function in Rheumatoid Arthritis

(2012) Beatrix Bartok et al.   AMERICAN JOURNAL OF PATHOLOGY

Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression

(2012) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

Rituximab modulates the expression of IL-22 in the salivary glands of patients with primary Sjogren's syndrome

(2012) Francesco Ciccia et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy of rituximab in systemic manifestations of primary Sjögren's syndrome: results in 78 patients of the AutoImmune and Rituximab registry

(2012) Jacques-Eric Gottenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

CD22 ligation inhibits downstream B cell receptor signaling and Ca2+flux upon activation

(2012) N. Sieger et al.   ARTHRITIS AND RHEUMATISM

Type I interferons in Sjögren's syndrome

(2012) Yihong Yao et al.   AUTOIMMUNITY REVIEWS

Role of the frequency of blood CD4+ CXCR5+ CCR6+ T cells in autoimmunity in patients with Sjögren’s syndrome

(2012) Xue-yi Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytokine/chemokine profiles contribute to understanding the pathogenesis and diagnosis of primary Sjögren's syndrome

(2012) M. Moriyama et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

STAT5 is a potent negative regulator of TFHcell differentiation

(2012) Robert J. Johnston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Interleukin-1 Inhibition and Fatigue in Primary Sjögren's Syndrome – A Double Blind, Randomised Clinical Trial

(2012) Katrine Brække Norheim et al.   PLoS One

Skewed Production of IL-6 and TGFβ by Cultured Salivary Gland Epithelial Cells from Patients with Sjögren's Syndrome

(2012) Takafumi Kawanami et al.   PLoS One

Local Administration of Soluble CD40:Fc to the Salivary Glands of Non-Obese Diabetic Mice Does Not Ameliorate Autoimmune Inflammation

(2012) Nienke Roescher et al.   PLoS One

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction

(2012) B. J. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BLyS upregulation in Sjogren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands

(2012) L. Quartuccio et al.   RHEUMATOLOGY

The Role of Ectopic Germinal Centers in the Immunopathology of Primary Sjögren's Syndrome: A Systematic Review

(2012) Anna P. Risselada et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

American College of Rheumatology classification criteria for Sjögren's syndrome: A data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance Cohort

(2012) S. C. Shiboski et al.   ARTHRITIS CARE & RESEARCH

Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome

(2012) Hongen Yin et al.   ARTHRITIS RESEARCH & THERAPY

Gene therapy using IL-27 ameliorates Sjögren's syndrome-like autoimmune exocrinopathy

(2012) Byung Lee et al.   ARTHRITIS RESEARCH & THERAPY

Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjogren's syndrome

(2011) E. Theander et al.   ANNALS OF THE RHEUMATIC DISEASES

Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjögren's syndrome

(2011) Francesco Ciccia et al.   ANNALS OF THE RHEUMATIC DISEASES

The anti-CD20 antibody rituximab reduces the Th17 cell response

(2011) Frank L. van de Veerdonk et al.   ARTHRITIS AND RHEUMATISM

In Sjögren's syndrome, B lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase C delta activation

(2011) Marie-Michèle Varin et al.   AUTOIMMUNITY REVIEWS

Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjögren's syndrome: clinical implications and effects of B cell-targeted therapies

(2011) A. Vossenkämper et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Enhanced Phosphoinositide 3-Kinase   Activity Is a Frequent Event in Systemic Lupus Erythematosus That Confers Resistance to Activation-Induced T Cell Death

(2011) A. Suarez-Fueyo et al.   JOURNAL OF IMMUNOLOGY

Effect of Soluble ICAM-1 on a Sjögren's Syndrome-like Phenotype in NOD Mice Is Disease Stage Dependent

(2011) Nienke Roescher et al.   PLoS One

Expression of Interleukin-22 in Sjögren’s Syndrome: Significant Correlation with Disease Parameters

(2011) T. N. Lavoie et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer

(2011) Cuong Q Nguyen et al.   ARTHRITIS RESEARCH & THERAPY

Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome

(2011) Roy A Fava et al.   ARTHRITIS RESEARCH & THERAPY

Disturbance of cytokine networks in Sjögren's syndrome

(2011) Pierre Youinou et al.   ARTHRITIS RESEARCH & THERAPY

Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands

(2011) Kwi Kang et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin-1 as a Phenotypic Immunomodulator in Keratinizing Squamous Metaplasia of the Ocular Surface in Sjögren's Syndrome

(2010) Ying-Ting Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Effectiveness of rituximab treatment in primary Sjögren's syndrome: A randomized, double-blind, placebo-controlled trial

(2010) J. M. Meijer et al.   ARTHRITIS AND RHEUMATISM

Functional role of M3 muscarinic acetylcholine receptor (M3R) reactive T cells and anti-M3R autoantibodies in patients with Sjögren's syndrome

(2010) Takayuki Sumida et al.   AUTOIMMUNITY REVIEWS

Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome

(2010) G Nordmark et al.   GENES AND IMMUNITY

Treatment of Primary Sjögren Syndrome

(2010) Manuel Ramos-Casals et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjögren’s syndrome-like sialoadenitis

(2010) Mana Iizuka et al.   JOURNAL OF AUTOIMMUNITY

IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer

(2010) Cuong Q Nguyen et al.   LABORATORY INVESTIGATION

B-cell Activating Factor of the Tumour Necrosis Factor Family Expression in Blood Monocytes and T Cells from Patients with Primary Sjögren’s Syndrome

(2010) F. Lavie et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Systemic and Local Interleukin-17 and Linked Cytokines Associated with Sjögren’s Syndrome Immunopathogenesis

(2009) Gikas E. Katsifis et al.   AMERICAN JOURNAL OF PATHOLOGY

Sjögren’s Syndrome-Like Ocular Surface Disease in Thrombospondin-1 Deficient Mice

(2009) Bruce Turpie et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome

(2009) Jelle L. Vosters et al.   ARTHRITIS AND RHEUMATISM

Clinical and histologic evidence of salivary gland restoration supports the efficacy of rituximab treatment in Sjögren's syndrome

(2009) J. Pijpe et al.   ARTHRITIS AND RHEUMATISM

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

(2009) Lakshmi Srinivasan et al.   CELL

Janus kinases in immune cell signaling

(2009) Kamran Ghoreschi et al.   IMMUNOLOGICAL REVIEWS

Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome

(2009) Maria I. Christodoulou et al.   JOURNAL OF AUTOIMMUNITY

Integrins in immunity

(2009) R. Evans et al.   JOURNAL OF CELL SCIENCE

Targeted but not trouble-free: efalizumab and PML

(2009) Eamonn S. Molloy et al.   Nature Reviews Rheumatology

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efalizumab binding to the LFA-1  L I domain blocks ICAM-1 binding via steric hindrance

(2009) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren syndrome in salivary glands of non-obese diabetic mice

(2009) Margaret K Gatumu et al.   ARTHRITIS RESEARCH & THERAPY

Reduction of fatigue in Sjogren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study

(2008) S Dass et al.   ANNALS OF THE RHEUMATIC DISEASES

Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: Findings in humans and mice

(2008) Cuong Q. Nguyen et al.   ARTHRITIS AND RHEUMATISM

Systemic increase in type I interferon activity in Sjögren's syndrome: A putative role for plasmacytoid dendritic cells

(2008) Manon E. Wildenberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of PI3Kδ and PI3Kγ in inflammatory arthritis and tissue localization of neutrophils

(2008) Tara M. Randis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

(2008) Tomoki Ito et al.   IMMUNITY

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

(2008) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY