Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Altered expression of TRAIL on mouse T cells via ERK phosphorylation by Rhodiola rosea L. and its marker compounds

(2017) Andrey S. Marchev et al.   FOOD AND CHEMICAL TOXICOLOGY

Rapid screening of potential α-amylase inhibitors from Rhodiola rosea by UPLC-DAD-TOF-MS/MS-based metabolomic method

(2017) Chaoyang Ma et al.   Journal of Functional Foods

Treatment with Rhodiola crenulata root extract ameliorates insulin resistance in fructose-fed rats by modulating sarcolemmal and intracellular fatty acid translocase/CD36 redistribution in skeletal muscle

(2016) Ting Chen et al.   BMC Complementary and Alternative Medicine

Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathway

(2016) Kuen-Tze Lin et al.   BMC Complementary and Alternative Medicine

Quantitative Analysis of Salidroside and p-Tyrosol in the Traditional Tibetan Medicine Rhodiola crenulata by Fourier Transform Near-Infrared Spectroscopy

(2016) Tao Li et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Antihyperalgesic Activity ofRhodiolaroseain a Diabetic Rat Model

(2016) Myrna Déciga-Campos et al.   DRUG DEVELOPMENT RESEARCH

Beneficial effect of commercial Rhodiola extract in rats with scopolamine-induced memory impairment on active avoidance

(2016) Liliya V. Vasileva et al.   JOURNAL OF ETHNOPHARMACOLOGY

Characterization of chemical constituents in Rhodiola Crenulate by high-performance liquid chromatography coupled with Fourier-transform ion cyclotron resonance mass spectrometer (HPLC-FT-ICR MS)

(2016) Fei Han et al.   JOURNAL OF MASS SPECTROMETRY

In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products

(2016) Ole Kristian Thu et al.   PHARMACEUTICAL BIOLOGY

Rhodiola crenulata induces an early estrogenic response and reduces proliferation and tumorsphere formation over time in MCF7 breast cancer cells

(2016) Lotfi M. Bassa et al.   PHYTOMEDICINE

Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

(2016) Tzong-Huei Lee et al.   PLANTA MEDICA

A rapid and sensitive UHPLC-FT-ICR MS/MS method for identification of chemical constituents in Rhodiola crenulata extract, rat plasma and rat brain after oral administration

(2016) Fei Han et al.   TALANTA

From Traditional Resource to Global Commodities:—A Comparison of Rhodiola Species Using NMR Spectroscopy—Metabolomics and HPTLC

(2016) Anthony Booker et al.   Frontiers in Pharmacology

Effects of rhodiola crenulata on mice hearts under severe sleep apnea

(2015) Mei-Chih Lai et al.   BMC Complementary and Alternative Medicine

Rhodiola rosea suppresses thymus T-lymphocyte apoptosis by downregulating tumor necrosis factor-α-induced protein 8-like-2 in septic rats

(2015) MING-WEI LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Rhodiola crenulata inhibits Wnt/β-catenin signaling in glioblastoma

(2015) Maria Carmen Mora et al.   JOURNAL OF SURGICAL RESEARCH

Phenolic Compounds from the Roots of Rhodiola crenulata and Their Antioxidant and Inducing IFN-γ Production Activities

(2015) Jiang-Tao Zhou et al.   MOLECULES

Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial

(2015) Jun J. Mao et al.   PHYTOMEDICINE

Rhodiola crenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway

(2015) Shih-Yu Lee et al.   PHYTOMEDICINE

Antineoplastic effects of Rhodiola crenulata treatment on B16-F10 melanoma

(2015) Maxine C. Dudek et al.   TUMOR BIOLOGY

Survey of commercial Rhodiola products revealed species diversity and potential safety issues

(2015) Tianyi Xin et al.   Scientific Reports

Bioactivity-Guided Fractionation of an Antidiarrheal Chinese Herb Rhodiola kirilowii (Regel) Maxim Reveals (-)–Epicatechin-3-Gallate and (-)–Epigallocatechin-3-Gallate as Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator

(2015) Lei Chen et al.   PLoS One

Adjunctive Treatment with Rhodiola Crenulata in Patients with Chronic Obstructive Pulmonary Disease – A Randomized Placebo Controlled Double Blind Clinical Trial

(2015) Ming-Lung Chuang et al.   PLoS One

Antihyperglycemic action of rhodiola-aqeous extract in type1-like diabetic rats

(2014) Chiang-Shan Niu et al.   BMC Complementary and Alternative Medicine

The efficacy and safety of Chinese herbal medicine, Rhodiola formulation in treating ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials

(2014) Lei Yu et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Hydroalcoholic extract of Rhodiola rosea L. (Crassulaceae) and its hydrolysate inhibit melanogenesis in B16F0 cells by regulating the CREB/MITF/tyrosinase pathway

(2014) Hsiu-Mei Chiang et al.   FOOD AND CHEMICAL TOXICOLOGY

Isolation and characterization of α-glucosidase inhibitory constituents from Rhodiola crenulata

(2014) Yung-Hung Chu et al.   FOOD RESEARCH INTERNATIONAL

Rhodiola crenulata- and Cordyceps sinensis-Based Supplement Boosts Aerobic Exercise Performance after Short-Term High Altitude Training

(2014) Chung-Yu Chen et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Inhibition of Xanthine Oxidase by Rhodiola crenulata Extracts and Their Phytochemicals

(2014) Yung-Hung Chu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Application and recovery of ionic liquids in the preparative separation of four flavonoids fromRhodiola roseaby on-line three-dimensional liquid chromatography

(2014) Shufeng Ma et al.   JOURNAL OF SEPARATION SCIENCE

Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: An interactive pathway analysis of the downstream effects using RNA microarray data

(2014) Alexander Panossian et al.   PHYTOMEDICINE

The Protective Effects ofRhodiola crenulataExtracts onDrosophila melanogasterGut Immunity Induced by Bacteria and SDS Toxicity

(2014) Caixia Zhu et al.   PHYTOTHERAPY RESEARCH

Rhodiola Rosea for Mental and Physical Fatigue in Nursing Students: A Randomized Controlled Trial

(2014) Salima Punja et al.   PLoS One

Rhodiola crenulata extract for prevention of acute mountain sickness: a randomized, double-blind, placebo-controlled, crossover trial

(2013) Te-Fa Chiu et al.   BMC Complementary and Alternative Medicine

Rhodiola roseaImpairs Acquisition and Expression of Conditioned Place Preference Induced by Cocaine

(2013) Federica Titomanlio et al.   Evidence-based Complementary and Alternative Medicine

Separation of four flavonoids from Rhodiola rosea by on-line combination of sample preparation and counter-current chromatography

(2013) Chaoyang Ma et al.   JOURNAL OF CHROMATOGRAPHY A

Alleviation of Kidney Damage Induced by Unilateral Ureter Obstruction in Rats by Rhodiola rosea

(2013) Ugur Uyeturk et al.   JOURNAL OF ENDOUROLOGY

Pharmacokinetic Interaction between Losartan andRhodiola roseain Rabbits

(2013) M. Spanakis et al.   PHARMACOLOGY

Synergistic interactions between the antinociceptive effect of Rhodiola rosea extract and B vitamins in the mouse formalin test

(2013) Rosa Mariana Montiel-Ruiz et al.   PHYTOMEDICINE

A Rhodiola Rosea Root Extract Protects Skeletal Muscle Cells Against Chemically Induced Oxidative Stress by Modulating Heat Shock Protein 70 (HSP70) Expression

(2013) Aaron Hernández-Santana et al.   PHYTOTHERAPY RESEARCH

Characterization of the Anxiolytic Activity of Nunavik Rhodiola rosea

(2013) Christian Cayer et al.   PLANTA MEDICA

Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction

(2013) Samuel E. Schriner et al.   PLoS One

Rhodiola rosea L. extract and its active compound salidroside antagonized both induction and reinstatement of nicotine place preference in mice

(2013) Federica Titomanlio et al.   PSYCHOPHARMACOLOGY

Prevention of Torsion-induced Testicular Injury by Rhodiola rosea

(2013) Ugur Uyeturk et al.   UROLOGY

Protective Effects of Salidroside on Epirubicin-Induced Early Left Ventricular Regional Systolic Dysfunction in Patients with Breast Cancer

(2013) Hua Zhang et al.   Drugs in research & development

Rhodiola rosea for physical and mental fatigue: a systematic review

(2012) Sana Ishaque et al.   BMC Complementary and Alternative Medicine

Neuropharmacological and Toxicity Evaluations of Ethanol Extract from RhodiolaRosea

(2012) Rosa Mariana Montiel-Ruiz et al.   DRUG DEVELOPMENT RESEARCH

Isolation, identification and antioxidative capacity of water-soluble phenylpropanoid compounds from Rhodiola crenulata

(2012) Danjun Chen et al.   FOOD CHEMISTRY

Lignans from the Root of Rhodiola crenulata

(2012) Ya-nan Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Two new compounds from the roots ofRhodiola crenulata

(2012) Ya-Nan Yang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Increase of myocardial performance by Rhodiola–ethanol extract in diabetic rats

(2012) Yung-Ze Cheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rhodiola crenulata root ameliorates derangements of glucose and lipid metabolism in a rat model of the metabolic syndrome and type 2 diabetes

(2012) Jianwei Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR

(2012) Kang In Choe et al.   MOLECULES

Purification of Phenylalkanoids and Monoterpene Glycosides fromRhodiola roseaL. Roots by High-speed Counter-current Chromatography

(2012) Elizabeth Mudge et al.   PHYTOCHEMICAL ANALYSIS

Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats

(2012) C. Mannucci et al.   PHYTOMEDICINE

Therapeutic Effects and Safety of Rhodiola rosea Extract WS® 1375 in Subjects with Life-stress Symptoms - Results of an Open-label Study

(2012) D. Edwards et al.   PHYTOTHERAPY RESEARCH

Protective Effects of a Rhodiola Crenulata Extract and Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced Neural Injury in the Rat

(2012) Ze-qiang Qu et al.   PLoS One

Effects of a Rhodiola rosea L. extract on the acquisition, expression, extinction, and reinstatement of morphine-induced conditioned place preference in mice

(2012) Laura Mattioli et al.   PSYCHOPHARMACOLOGY

Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy

(2011) Zhongbo Liu et al.   MOLECULAR CARCINOGENESIS

The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae

(2011) Maria M. Bayliak et al.   PHYTOMEDICINE

In VivoTh1 and Th2 Cytokine Modulation Effects ofRhodiola roseaStandardised Solution and its Major Constituent, Salidroside

(2011) Shih-Shen Chou Lin et al.   PHYTOTHERAPY RESEARCH

Rhodiola rosea Extract Protects Human Cortical Neurons against Glutamate and Hydrogen Peroxide-induced Cell Death Through Reduction in the Accumulation of Intracellular Calcium

(2011) Dora Rita Palumbo et al.   PHYTOTHERAPY RESEARCH

Evaluation of salidrosidein vitroandin vivogenotoxicity

(2010) Jiangbo Zhu et al.   DRUG AND CHEMICAL TOXICOLOGY

Mating system and pollination biology of a high-mountain perennial plant, Rhodiola dumulosa (Crassulaceae)

(2010) L. Zhu et al.   Journal of Plant Ecology

Effects of a Rhodiola rosea L. extract on acquisition and expression of morphine tolerance and dependence in mice

(2010) Laura Mattioli et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells

(2010) Li Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating

(2010) Carlo Cifani et al.   PHYSIOLOGY & BEHAVIOR

Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions

(2010) G. Aslanyan et al.   PHYTOMEDICINE

Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy

(2010) A. Panossian et al.   PHYTOMEDICINE

The effectiveness and efficacy of Rhodiola rosea L.: A systematic review of randomized clinical trials

(2010) Shao Kang Hung et al.   PHYTOMEDICINE

Rhodiola-induced inhibition of adipogenesis involves antioxidant enzyme response associated with pentose phosphate pathway

(2010) Ok-Hwan Lee et al.   PHYTOTHERAPY RESEARCH

The Extract of Rhodiolae Crenulatae Radix et Rhizoma Induces the Accumulation of HIF-1αvia Blocking the Degradation Pathway in Cultured Kidney Fibroblasts

(2010) Ken Zheng et al.   PLANTA MEDICA

ChronicRhodiola roseaExtract Supplementation Enforces Exhaustive Swimming Tolerance

(2009) Fang-Tsai Lee et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Rhodiola rosea ability to enrich cellular antioxidant defences of cultured human keratinocytes

(2009) Cinzia Calcabrini et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Pretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective Effects

(2009) ZE-QIANG QU et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

RP-HPLC determination of phenylalkanoids and monoterpenoids inRhodiola roseaand identification by LC-ESI-TOF

(2009) Bharathi Avula et al.   BIOMEDICAL CHROMATOGRAPHY

Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities

(2009) Hyung Jae Jeong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance performance in healthy volunteers

(2009) Zhang-jin Zhang et al.   Chinese Journal of Integrative Medicine

Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses

(2009) Samuel E. Schriner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased mitochondrial superoxide levels and enhanced protection against paraquat inDrosophilamelanogastersupplemented withRhodiola rosea

(2009) Samuel E. Schriner et al.   FREE RADICAL RESEARCH

Monoamine oxidase inhibition by Rhodiola rosea L. roots

(2009) Daphne van Diermen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rhodiosin, an Antioxidant Flavonol Glycoside from Rhodiola rosea

(2009) Hyung-Jun Kwon   Journal of the Korean Society for Applied Biological Chemistry

The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats

(2009) Q.G. Chen et al.   PHYTOMEDICINE

Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones

(2009) Alexander Panossian et al.   PHYTOMEDICINE

Anti-inflammatory activity ofRhodiola rosea- “a second-generation adaptogen”

(2009) Pooja et al.   PHYTOTHERAPY RESEARCH

Potentin vitroInhibition of CYP3A4 and P-Glycoprotein byRhodiola rosea

(2009) Bent Hellum et al.   PLANTA MEDICA

Bioactive Constituents from Chinese Natural Medicines. XXIX. Monoterpene and Monoterpene Glycosides from the Roots of Rhodiola sachalinensis

(2008) Xuezheng Li et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Reinvestigation of Absolute Stereostructure of (−)-Rosiridol: Structures of Monoterpene Glycosides, Rosiridin, Rosiridosides A, B, and C, from Rhodiola sachalinensis

(2008) Masayuki Yoshikawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Bioactive Constituents from Chinese Natural Medicines. XXVIII. Chemical Structures of Acyclic Alcohol Glycosides from the Roots of Rhodiola crenulata

(2008) Seikou Nakamura et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

A dose dependent adaptogenic and safety evaluation of Rhodiola imbricata Edgew, a high altitude rhizome

(2008) V. Gupta et al.   FOOD AND CHEMICAL TOXICOLOGY

A Pilot Study of Rhodiola rosea (Rhodax®) for Generalized Anxiety Disorder (GAD)

(2008) Alexander Bystritsky et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Autonomic nervous system mediates the cardiovascular effects of Rhodiola sacra radix in rats

(2008) Cheng-Dean Shih et al.   JOURNAL OF ETHNOPHARMACOLOGY

Quality Evaluation ofRhodiola crenulata: Quantitative and Qualitative Analysis of Ten Main Components by HPLC

(2008) Hao Huang et al.   JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES

Rhodiola crenulata Induces Death and Inhibits Growth of Breast Cancer Cell Lines

(2008) Yifan Tu et al.   JOURNAL OF MEDICINAL FOOD

The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3

(2008) Haibo Wang et al.   PHYTOMEDICINE

Phenylalkanoids and Monoterpene Analogues from the Roots of Rhodiola rosea

(2008) Zulfiqar Ali et al.   PLANTA MEDICA

Constituents ofRhodiola roseaShowing Inhibitory Effect on Lipase Activity in Mouse Plasma and Alimentary Canal

(2008) Kyoko Kobayashi et al.   PLANTA MEDICA

A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Standardised Extract SHR-5 of the Roots ofRhodiola roseain the Treatment of Subjects with Stress-Related Fatigue

(2008) Erik Olsson et al.   PLANTA MEDICA

Anti-inflammatory activity of caffeic acid phenethyl ester (CAPE) extracted from Rhodiola sacra against lipopolysaccharide-induced inflammatory responses in mice

(2008) Won-Kyo Jung et al.   PROCESS BIOCHEMISTRY

Extraction of flavonoids fromRhodiola sachlinesisA. Bor by UPE and the antioxidant activity of its extract

(2007) Shouqin Zhang et al.   NATURAL PRODUCT RESEARCH

Comparative study of Rhodiola preparations on behavioral despair of rats

(2007) A. Panossian et al.   PHYTOMEDICINE