Article
Chemistry, Multidisciplinary
Jia Huang, Guiming Deng, Shuya Wang, Tianjiao Zhao, Qiaohui Chen, Yuqi Yang, Yongqi Yang, Jinping Zhang, Yayun Nan, Zhaoqian Liu, Ke Cao, Qiong Huang, Kelong Ai
Summary: A multifunctional nanoplatform (MCPQZ) with high-density cuprous (Cu2O) supported molybdenum disulfide (MoS2) nanoflowers (MC NFs) is developed for efficient tumor killing through a potent ROS storm. This work provides a novel insight to solve the bottleneck of ROS-based cancer therapy.
Article
Biotechnology & Applied Microbiology
Dongdong Wang, Xiaoyi Zhang, Bingbing Xu
Summary: Efforts to design and develop advanced drug delivery systems for targeted cancer chemotherapy remain a major challenge. A reduction-responsive PEGylated doxorubicin prodrug was reported, which self-assembled into biodegradable micelles in solutions and exhibited enhanced therapeutic efficacy with low side effects for targeted tumors. The reduction-sensitive micelles could also encapsulate free DOX drug into polymer cargo, showing potential as an intelligent and multifunctional chemotherapeutic payload transporter for effective tumor therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biophysics
Tao Wang, Wei He, Yawei Du, Ji Wang, Xinsong Li
Summary: A novel irinotecan encapsulated redox-responsive liposome was developed, which showed efficient loading and controlled release of irinotecan. The liposome exhibited superior antitumor activity and pharmacokinetic properties in cell and animal experiments, highlighting its potential as a new generation of irinotecan liposomal formulation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Jingjun Sun, Shuangjiu Zhu, Weixuan Xu, Guoqin Jiang
Summary: In this study, a complex nanoparticle was developed for synergistic chemo-photothermal therapy of breast cancer. The nanoparticles exhibited good photothermal effects and triggered drug release through temperature and redox responsiveness. In vitro studies showed effective induction of apoptosis in breast cancer cells through inhibition of heat shock proteins and the JAK-STAT signaling pathway. In a breast tumor-bearing mice model, the nanoparticles demonstrated significant inhibitory effects on cancer growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yaru Li, Simin Feng, Peipei Dai, Fang Liu, Yaqi Shang, Qian Yang, Juan Qin, Zhiguang Yuchi, Zheng Wang, Yanjun Zhao
Summary: A tailored Trojan horse nanocarrier with pH-labile zeolitic imidazolate framework-8 (ZIF-8) as the core and disulfide-linked amphiphilic polymer-drug conjugate as the steric shell is designed. The nanocarrier exhibits improved drug release and therapeutic efficacy through the collapse of ZIF-8 under low pH conditions, inducing the liberation and further cleavage of the drug.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Shirong Zheng, Manh Cuong Hoang, Van Du Nguyen, Gwangjun Go, Minghui Nan, Bobby Aditya Darmawan, Seokjae Kim, Seung-hyun Im, Taeksu Lee, Doyeon Bang, Jong-Oh Park, Eunpyo Choi
Summary: A magnetically guided helical microrobot with a Gyroid surface is proposed for high drug-loading efficiency and precise drug delivery. All spaces inside the microrobot are interconnected, enabling drug loading deep inside the structure. Gold nanostars are introduced for near-infrared-induced photothermal therapy and triggering drug release.
Article
Polymer Science
Arjaree Jobdeedamrong, Man Theerasilp, Nutthanit Thumrongsiri, Paweena Dana, Nattika Saengkrit, Daniel Crespy
Summary: In this study, GSH-responsive and self-immolative polyprodrug nanoparticles were prepared for cancer treatment. These nanoparticles showed high drug loading and efficient redox-responsive release, displaying high cytotoxicity against cancer cells and low cytotoxicity against cancer cells treated with GSH scavenger or normal cells.
Review
Biochemistry & Molecular Biology
Danielle M. Beaupre, Richard G. Weiss
Summary: The review focuses on the properties and applications of synthetic thiol- and disulfide-based materials, particularly polymers. The emphasis is on soft and self-assembling materials, where interconversion of thiol and disulfide groups can trigger stimulus-responses and self-healing, for both biomedical and non-biomedical applications.
Article
Materials Science, Multidisciplinary
Huaming He, Fang Zhao, Wukun Zhong, Yuling Yang, Yuhong Lin, Yihang Ding, Jiajia Yang, Chunhua Lu, Xiankun Tu
Summary: Mitochondria-targeting nanoparticles responsive to glutathione (GSH) were developed for precise targeting of mitochondria in tumor cells for photothermal-enhanced chemodynamic therapy (CDT). The nanoagents showed effective damage to mitochondrial function and induction of tumor cell apoptosis. This study provides a new treatment path in the field of cancer therapy.
MATERIALS & DESIGN
(2022)
Article
Oncology
Jian Song, Bingbing Xu, Hui Yao, Xiaofang Lu, Yang Tan, Bingyang Wang, Xing Wang, Zheng Yang
Summary: The study demonstrated a pH-responsive PEGylated doxorubicin prodrug that could achieve high drug loading and pH-responsive drug release within tumor cells, with good stability. Furthermore, the nanoparticles showed similar cytotoxicity to MCF-7 tumor cells as free DOX drug, and were able to encapsulate small DOX drugs with enhanced therapeutic effects.
FRONTIERS IN ONCOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Shabnam Sattari, Mohsen Adeli, Siamak Beyranvand, Mohammad Nemati
Summary: Two-dimensional nanomaterials, such as graphene, are promising candidates for various biomedical applications due to their high surface area and efficient cellular uptake. Functionalization of graphene is essential to improve its dispersion in water and functionality for future nanomedicine applications. Techniques involving covalent or non-covalent methods have been explored to enhance the physicochemical properties of graphene and graphene oxide.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biophysics
Jiaqian Li, Na Yang, Mei Yang, Chao Lu, Meng Xie
Summary: The targeted drug delivery system based on nanomaterials has great potential for cancer therapy as it can improve treatment efficacy and reduce side effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Jinsong Tao, Zhengjie Wei, Yaxin Cheng, Meng Xu, Qiuxia Li, Simon Ming-Yuen Lee, Wei Ge, Kathy Qian Luo, Xueqing Wang, Ying Zheng
Summary: A transparent zebrafish model offers advantages for preclinical screening and evaluation. In this study, an apoptosis-sensing xenograft zebrafish tumor model was established to evaluate the anti-cancer effects of redox-responsive cross-linked Pluronic polymeric micelles. The model provides a visual, rapid, effective, and noninvasive assessment of anti-cancer effects at the cellular level.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Weirong Kang, Yuwei Liu, Weiping Wang
Summary: Immunotherapy has revolutionized cancer treatments by activating the immune system to effectively inhibit cancer progression. Recent advances in cancer immunotherapy, such as checkpoint blockades and adoptive cellular therapy, have shown remarkable clinical outcomes. However, low response rates and side effects limit the widespread use of immunotherapy. Nanomedicine, specifically light-responsive nanoplatforms, show promise in enhancing immunotherapy by precise drug delivery and modulation of the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Engineering, Biomedical
Xuan Meng, Lin Wang, Ning Zhao, Delong Zhao, Yongli Shen, Yuan Yao, Wenjie Jing, Shuli Man, Yujie Dai, Yanjun Zhao
Summary: This study reports a hybrid nanocarrier that targets glycolysis and redox balance simultaneously for cancer therapy. The nanocarrier, composed of pH-and ATP-responsive ZIF-8 core and poloxamer 407 coating, delivers glucose oxidase and 3-bromopyruvate to liver hepatocellular carcinoma cells, effectively inhibiting cellular energy metabolism and reducing cell viability. This approach enriches the available strategies for anti-tumor treatment.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Menglin Wang, Jin Sun, Yinglei Zhai, He Lian, Cong Luo, Lin Li, Yuqian Du, Dong Zhang, Wenya Ding, Shuhong Qiu, Yuhai Liu, Longfa Kou, Xiangfei Han, Rongwu Xiang, Yongjun Wang, Zhonggui He
Article
Biochemical Research Methods
Peng Xue, Dan Liu, Jing Wang, Na Zhang, Jiahua Zhou, Lin Li, Weiling Guo, Mengchi Sun, Xiangfei Han, Yongjun Wang
BIOCONJUGATE CHEMISTRY
(2016)
Article
Biophysics
Xiangfei Han, Menglin Wang, Zhihui Ma, Peng Xue, Yongjun Wang
COLLOIDS AND SURFACES B-BIOINTERFACES
(2016)
Article
Pharmacology & Pharmacy
Yingli Wang, Xiangfei Han, Jing Wang, Yongjun Wang
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2016)
Article
Chemistry, Multidisciplinary
Mengjuan Jiang, Xiangfei Han, Weiling Guo, Wei Li, Jinling Chen, Guolian Ren, Bingjun Sun, Yongjun Wang, Zhonggui He
Review
Biophysics
Peng Xue, Jing Wang, Xiangfei Han, Yongjun Wang
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Review
Nanoscience & Nanotechnology
Boyi Song, Ershuai Zhang, Xiangfei Han, Hui Zhu, Yuanjie Shi, Zhiqiang Cao
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Nanoscience & Nanotechnology
Xiangfei Han, Yang Lu, Jinbing Xie, Ershuai Zhang, Hui Zhu, Hong Du, Ke Wang, Boyi Song, Chengbiao Yang, Yuanjie Shi, Zhiqiang Cao
NATURE NANOTECHNOLOGY
(2020)
Review
Materials Science, Biomaterials
Xiangfei Han, Ershuai Zhang, Yuanjie Shi, Boyi Song, Hong Du, Zhiqiang Cao
JOURNAL OF MATERIALS CHEMISTRY B
(2019)