Exocytosis of Weibel–Palade bodies: how to unpack a vascular emergency kit

Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial CellsHighlights

(2018) Maaike Schillemans et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Clathrin-mediated post-fusion membrane retrieval influences the exocytic mode of endothelial Weibel-Palade bodies

(2017) Nicola L. Stevenson et al.   JOURNAL OF CELL SCIENCE

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel–Palade body exocytosis in endothelial cells

(2017) Tarek Chehab et al.   MOLECULAR BIOLOGY OF THE CELL

Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules

(2017) Xiaofan Han et al.   Nature Communications

von Willebrand factor multimerization and the polarity of secretory pathways in endothelial cells

(2016) M. Lopes da Silva et al.   BLOOD

Von Willebrand’s Disease

(2016) Frank W.G. Leebeek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Is there more than one way to unpack a Weibel-Palade body?

(2015) I. L. Conte et al.   BLOOD

Membrane tension and membrane fusion

(2015) Michael M Kozlov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Interaction between MyRIP and the actin cytoskeleton regulates Weibel–Palade body trafficking and exocytosis

(2015) Ianina L. Conte et al.   JOURNAL OF CELL SCIENCE

CLEC4MandSTXBP5gene variations contribute to von Willebrand factor level variation in von Willebrand disease

(2015) Y. V. Sanders et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor

(2015) Qiuyu Zhu et al.   PLoS One

STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a

(2014) D. van Breevoort et al.   BLOOD

von Willebrand factor, Jedi knight of the bloodstream

(2014) T. A. Springer   BLOOD

Von Willebrand factor and ADAMTS13 in arterial thrombosis: a systematic review and meta-analysis

(2014) Michelle A.H. Sonneveld et al.   BLOOD REVIEWS

Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

(2014) Qiuyu Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Cargo Mobilisation within Weibel-Palade Bodies after Transient Fusion with the Plasma Membrane

(2014) Nikolai I. Kiskin et al.   PLoS One

Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease

(2013) J.-W. Wang et al.   BLOOD

cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2

(2013) I. Brandherm et al.   BLOOD

Rab GTPases and membrane identity: Causal or inconsequential?

(2013) Francis A. Barr   JOURNAL OF CELL BIOLOGY

Characterisation of Weibel-Palade body fusion by amperometry in endothelial cells reveals fusion pore dynamics and the effect of cholesterol on exocytosis

(2013) E. A. Cookson et al.   JOURNAL OF CELL SCIENCE

von Willebrand factor remodeling during exocytosis from vascular endothelial cells

(2013) M. J. Mourik et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reduced prevalence of arterial thrombosis in von Willebrand disease

(2013) Y. V. Sanders et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 regulates epinephrine-induced exocytosis of Weibel-Palade bodies

(2013) K. W. E. M. van Hooren et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Identification of Galectin-1 and Galectin-3 as Novel Partners for Von Willebrand Factor

(2012) Nathalie Saint-Lu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner

(2012) J. Huang et al.   BLOOD

Unwinding the von Willebrand factor strings puzzle

(2012) K. De Ceunynck et al.   BLOOD

The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis

(2012) R. Bierings et al.   BLOOD

Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells

(2012) D. Zhu et al.   DIABETOLOGIA

The Epac-Rap1 Signaling Pathway Controls cAMP-mediated Exocytosis of Weibel-Palade Bodies in Endothelial Cells

(2012) Kathinka W. E. M. van Hooren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis

(2012) S. Zografou et al.   JOURNAL OF CELL SCIENCE

Proteomic Screen Identifies IGFBP7 as a Novel Component of Endothelial Cell-Specific Weibel-Palade Bodies

(2012) Dorothee van Breevoort et al.   JOURNAL OF PROTEOME RESEARCH

The Shear Stress-Induced Transcription Factor KLF2 Affects Dynamics and Angiopoietin-2 Content of Weibel-Palade Bodies

(2012) Ellen L. van Agtmaal et al.   PLoS One

Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association

(2012) K. C. Desch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional architecture of Weibel-Palade bodies

(2011) K. M. Valentijn et al.   BLOOD

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

(2011) F. Liu et al.   BLOOD

Vesicle-associated Membrane Protein 8 (VAMP8) Is a SNARE (SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion

(2011) Natasha Behrendorff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actomyosin II contractility expels von Willebrand factor from Weibel–Palade bodies during exocytosis

(2011) Thomas D. Nightingale et al.   JOURNAL OF CELL BIOLOGY

Myosin Va Acts in Concert with Rab27a and MyRIP to Regulate Acute Von-Willebrand Factor Release from Endothelial Cells

(2011) Inés Rojo Pulido et al.   TRAFFIC

VAMP3 is associated with endothelial Weibel–Palade bodies and participates in their Ca2+-dependent exocytosis

(2010) Inés Rojo Pulido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endothelial von Willebrand factor regulates angiogenesis

(2010) R. D. Starke et al.   BLOOD

Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis

(2010) N. L. Smith et al.   BLOOD

A revised model for the secretion of tPA and cytokines from cultured endothelial cells

(2010) L. Knipe et al.   BLOOD

Multigranular exocytosis of Weibel-Palade bodies in vascular endothelial cells

(2010) K. M. Valentijn et al.   BLOOD

Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor

(2010) Nicholas L. Smith et al.   CIRCULATION

Effect of Genetic Variations in Syntaxin-Binding Protein-5 and Syntaxin-2 on von Willebrand Factor Concentration and Cardiovascular Risk

(2010) Janine E. van Loon et al.   Circulation-Cardiovascular Genetics

Cell biology of Ca2+-triggered exocytosis

(2010) Zhiping P Pang et al.   CURRENT OPINION IN CELL BIOLOGY

Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells

(2009) T. D. Nightingale et al.   BLOOD

Vascular Endothelial Growth Factor (VEGF) Receptor-2 Tyrosine 1175 Signaling Controls VEGF-induced von Willebrand Factor Release from Endothelial Cells via Phospholipase C-γ1- and Protein Kinase A-dependent Pathways

(2009) Yan Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein phosphatase 2B inhibition promotes the secretion of von Willebrand factor from endothelial cells

(2009) L. H. NOLASCO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural organization of Weibel-Palade bodies revealed by cryo-EM of vitrified endothelial cells

(2009) J. A. Berriman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basal secretion of von Willebrand factor from human endothelial cells

(2008) J. P. Giblin et al.   BLOOD

Selective release of molecules from Weibel-Palade bodies during a lingering kiss

(2008) V. Babich et al.   BLOOD

Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells

(2008) J. Disse et al.   BLOOD

Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells

(2008) M. G. Rondaij et al.   BLOOD

Protein kinase C-δ mediates von Willebrand factor secretion from endothelial cells in response to vascular endothelial growth factor (VEGF) but not histamine

(2008) O. LORENZI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Assembly of Weibel Palade body-like tubules from N-terminal domains of von Willebrand factor

(2008) R.-H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA