Article
Microbiology
Nada T. Felifel, Mahmoud A. Sliem, Zienat Kamel, Joanna Bojarska, Mohamed G. Seadawy, Rehab M. Amin, Sherif M. Elnagdy
Summary: Multidrug-resistant microorganisms pose a significant public health threat, and the use of traditional antibiotics is becoming less effective. Photodynamic therapy (PDT), which utilizes photosensitizers and light to generate Reactive Oxygen Species (ROS) for microorganism killing, shows promise as an alternative. Zinc phthalocyanine (ZnPc) is a potentially suitable photosensitizer due to its antimicrobial properties and ability to be encapsulated in nanoemulsions. In this study, a nanoemulsion was prepared using Miglyol 812N and distilled water, serving as an efficient nanocarrier system for hydrophobic drugs such as ZnPc. The results demonstrated that ZnPc encapsulated in the nanoemulsion significantly reduced cell survival percentages of Staphylococcus aureus and Escherichia coli, highlighting the potential of nanoemulsion-based PDT as an effective alternative for treating multidrug-resistant microorganisms.
Review
Pharmacology & Pharmacy
Tulio Morandin Ferrisse, Luana Mendonca Dias, Analu Barros de Oliveira, Claudia Carolina Jordao, Ewerton Garcia de Oliveira Mima, Ana Claudia Pavarina
Summary: This study performed a systematic review and meta-analysis to evaluate the efficacy of antimicrobial photodynamic therapy (aPDT) mediated by photosensitizers (PS) conjugated with inorganic nanoparticles. The results showed that this combination approach significantly reduced the number of microorganisms cultured in suspension, particularly for E. coli and Gram-negative bacteria. However, further studies are needed to evaluate the efficacy of this therapy on microorganisms cultured in biofilm.
Article
Chemistry, Applied
Ranulfo Combuca da Silva Junior, Katieli da Silva Souza Campanholi, Fabiana dos Santos Rando, Renato Sonchini Goncalves, Daniele Lazarin-Bidoia, Flavia Amanda Pedroso de Morais, Ana Paula Alves dos Santos Silva, Celso Vataru Nakamura, Magali Soares dos Santos Pozza, Wilker Caetano
Summary: The study aimed to evaluate the photodynamic efficiency of Safranine-O in inactivating Escherichia coli and Staphylococcus aureus, with promising results showing effective inactivation of both bacteria.
Article
Acoustics
Yixuan Xu, Shiyang Liu, Hongyou Zhao, Yi Li, Chao Cui, Wenxin Chou, Yuxia Zhao, Jiyong Yang, Haixia Qiu, Jing Zeng, Defu Chen, Shengnan Wu, Yizhou Tan, Ying Wang, Ying Gu
Summary: Combining ultrasonic irradiation with antimicrobial photodynamic therapy (aPDT) enhances the efficacy of aPDT against MRSA biofilm by increasing the penetration depth of the photosensitizer (PS) and without affecting the viability of human dermal fibroblasts. This study suggests that the combination of aPDT and ultrasound is a potential and promising strategy for eradicating biofilm-associated infections of MRSA.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Physical
Pinar Sen, John Mack, Tebello Nyokong
Summary: In this study, a series of new tetra-substituted indium phthalocyanine (InPc) complexes were prepared and their photodynamic antimicrobial activities were evaluated. The results showed that one of the complexes, 4, exhibited high antimicrobial activity under specific conditions.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Pharmacology & Pharmacy
Aiman Batool, Mercy Bore, Jingwen Wu, Chaoyu Li, Hongjuan Zeng
Summary: The combination of silver nanoparticles and cefazolin can enhance the antibacterial effectiveness of cefazolin, exhibiting strong antibacterial activity against Escherichia coli and Staphylococcus aureus.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Oncology
Isabelle de Paula Ribeiro, Juliana Guerra Pinto, Beatriz Muller Nunes Souza, Alejandro Guillermo Minan, Juliana Ferreira-Strixino
Summary: Antimicrobial Photodynamic Therapy (aPDT) with curcumin was shown to reduce the growth of MRSA biofilm without cytotoxicity, providing a relevant alternative possibility for the inactivation of this strain.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Infectious Diseases
Michela Galgano, Paolo Capozza, Francesco Pellegrini, Marco Cordisco, Alessio Sposato, Sabina Sblano, Michele Camero, Gianvito Lanave, Giuseppe Fracchiolla, Marialaura Corrente, Francesco Cirone, Adriana Trotta, Maria Tempesta, Domenico Buonavoglia, Annamaria Pratelli
Summary: The study found that essential oils such as lemon, pine, fennel, basil, melissa, thyme, and ginger have broad-spectrum antimicrobial activity. The activity of ginger oil against Staphylococcus aureus strains showed a dose-effect correlation, while fennel oil showed low activity. Pine, melissa, and basil oils showed bactericidal effects against S. aureus, and lemon oil had different effects on different strains. Thyme oil showed complete inhibition of growth for both E. coli and S. aureus.
Article
Infectious Diseases
Viviana Teresa Orlandi, Eleonora Martegani, Nicola Trivellin, Fabrizio Bolognese, Enrico Caruso
Summary: Photodynamic Antimicrobial Chemotherapy (PACT) has gained attention for its effectiveness in treating oral and skin infections and its ability to overcome antimicrobial resistance. This study investigated the potential of 13 diaryl-porphyrins as photosensitizers against Staphylococcus aureus. Among the compounds tested, the neutral photosensitizer P4 showed the highest inhibitory activity against biofilm formation.
Article
Multidisciplinary Sciences
Jace A. Willis, Vsevolod Cheburkanov, Shaorong Chen, Jennifer M. Soares, Giulia Kassab, Kate C. Blanco, Vanderlei S. Bagnato, Paul de Figueiredo, Vladislav V. Yakovlev
Summary: The widespread use of antibiotics contributes to the evolution of antimicrobial-resistant bacteria, posing a threat to patients and healthcare professionals. Developing strategies to combat resistance is recognized as a global healthcare priority. In this study, a method using antimicrobial photodynamic therapy (aPDT) in conjunction with antibiotics is proposed to reduce resistance and extend the lifespan of current antibiotics. The results show that concurrent treatment of bacteria with antibiotics and aPDT significantly decreases the resistance of methicillin-resistant Staphylococcus aureus (MRSA) strains, suggesting a potential alternative for overcoming the challenge of growing MRSA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yeseul Kim, Sanghun Kim, Kiu-Hyung Cho, Jin-Hyung Lee, Jintae Lee
Summary: Bacterial biofilm formation can be effectively inhibited by cinnamaldehyde and its derivatives, especially 4-nitrocinnamaldehyde. These compounds exhibit strong antibiofilm activities against UPEC and S. aureus, making them promising candidates for the treatment of biofilm-associated diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
L. Collen Makola, Sithi Mgidlana, Tebello Nyokong
Summary: This study focuses on the synthesis, characterization, and application of indium porphyrins linked to silver core-shell magnetic nanoparticles for in vitro photodynamic antimicrobial chemotherapy. The research compares the photophysicochemical properties and activities of different indium porphyrin complexes based on their structure and charges, and examines the hydrophilic and hydrophobic characteristics of the amphiphilic porphyrins by comparing different alkyl halides quaternizing agents. Furthermore, the porphyrin complexes are linked to magnetic nanoparticles to enhance antimicrobial synergy and allow for recovery after use, resulting in high Log reduction values.
Article
Biochemistry & Molecular Biology
Mafalda Bispo, Sabrina Suhani, Jan Maarten van Dijl
Summary: This study revealed that human serum albumin could reduce the efficacy of targeted antimicrobial photodynamic therapy against MRSA, while the addition of non-toxic potassium iodide could enhance the eradication of MRSA.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Chemistry, Physical
Pinar Sen, Tebello Nyokong
Summary: In this study, Schiff base substituted neutral phthalocyanines derived from aldehyde substituted phthalocyanine were conjugated to silver nanoparticles through strong interactions. The photophysicochemical properties and photodynamic antimicrobial chemotherapy activities of the nanoconjugates were investigated, showing excellent antimicrobial activity with 100% reduction against Staphylococcus aureus.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biotechnology & Applied Microbiology
So-Seum Yong, Jae-Ik Lee, Dong-Hyun Kang
Summary: This study investigated the photocatalytic activity of TiO2-based photocatalysts in inactivating foodborne pathogens in various environments. The results showed that Degussa P25 under UVA exhibited the highest bactericidal effects.
Article
Pharmacology & Pharmacy
Naz Ugur, Ersan Harputlu, Canan Vejselova Sezer, Ruken Esra Demirdogen, Mine Ince, C. Gokhan Unlu, Fatma Yurt, Fatih Mehmet Emen, Hatice Mehtap Kutlu, Kasim Ocakoglu
Summary: Uniformly dispersed hollow mesoporous carbon nanoparticles (HMCNPs) were successfully synthesized by hard-template methods, and D-NMAPPD (B13) was loaded onto the nanoparticle surface for the first time. The structural properties of the loaded nanoparticles were investigated, and their inhibitory effect on lung cancer cells was determined in vitro.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Umit Toktas, Nazli Boke Sarikahya, Cemal Parlak, Ismail Ozturk, Husniye Kayalar
Summary: This study identified the phytochemical content and biological effects of Galium as-paragifolium, revealing a new compound, galiumic acid, along with other known compounds. The compounds and extracts showed varying levels of antimicrobial activity and antioxidant effects, with the new compound's structure elucidated through computational studies.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Crystallography
Selma Erat, Artur Braun, Samed cetinkaya, Saadet Yildirimcan, Ahmet Emre Kasapoglu, Emre Guer, Ersan Harputlu, Kasim Ocakoglu
Summary: Intrinsic and dandelion-like microflower nano-rod structures of boron-doped ZnO thin films were successfully synthesized using an ecofriendly and cost-effective chemical bath deposition technique. The doping of boron decreased the optical band gap of ZnO and affected the arrangement of crystallites. The 1% B-doped ZnO film showed the lowest activation energy at both low and high temperatures, suggesting potential applications in gas sensors and solar cells.
Article
Pharmacology & Pharmacy
Huseyin Istanbullu, Gulsah Bayraktar, Ismail Ozturk, Gunes Coban, Merve Saylam
Summary: This study aimed to develop novel compounds to combat antimicrobial resistance. The synthesized compounds showed promising antimicrobial activity against various bacterial and fungal strains, with hybrid compound H5 exhibiting significant activity against Enterococcus faecalis and inhibition of biofilm production in Escherichia coli and Pseudomonas aeruginosa. Furthermore, it demonstrated a decreasing effect on the relative accumulation of ethidium bromide in P. aeruginosa. The study also reported the novel heterocyclic core structure of 2,5-disubstitued[1,2,4]triazolo[1,5-a]pyrimidinone and its antimicrobial activity for the first time.
JOURNAL OF RESEARCH IN PHARMACY
(2022)
Article
Biochemistry & Molecular Biology
Ayca Tuncel, Fatma Yurt
Summary: In this study, the chemo-PTT potential of a synthesized drug-loaded and targeted GEM/TRA-MC@Si nanocomposite was investigated on Her2 positive breast cancer cell line (SK-BR-3) and human triple-negative breast cancer cell line (MDA-MB-231) using NIR application as in vitro. The results demonstrated that the nanocomposite significantly reduced the cell viability of Her2 positive cells and induced cell death through the apoptosis pathway under optimized irradiation conditions.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Svetlana Yefimova, Vladimir Klochkov, Nataliya Kavok, Anton Tkachenko, Anatolii Onishchenko, Tatyana Chumachenko, Nadir Dizge, Sadin Ozdemir, Serpil Gonca, Kasim Ocakoglu
Summary: The study evaluated the antimicrobial activity of cerium oxide nanoparticles and their cytotoxicity towards eukaryotic cells. The results showed that these nanoparticles exhibited moderate antimicrobial activity and low cytotoxicity towards erythrocytes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Chemistry, Physical
Buse Sert, Zeynep Bilici, Kasim Ocakoglu, Nadir Dizge, Tannaz Sadeghi Rad, Alireza Khataee
Summary: In this study, a g-C3N4-based ZnO heterostructure was synthesized using a calcination method with urea and zinc nitrate hexahydrate. The SEM images showed spherical ZnO particles on the g-C3N4 nanosheets. XRD analysis confirmed the successful synthesis of the g-C3N4/ZnO. The photocatalytic activity of the catalyst was tested for crystal violet (CV) decolorization, and the degradation efficiency was affected by ZnO molar ratio, catalyst amount, CV concentration, and H2O2 concentration.
Article
Thermodynamics
Ridvan Kucukosman, Huseyin Degirmenci, Ahmet Alper Yontar, Kasim Ocakoglu
Summary: This study demonstrates that gasoline-based fuels containing boron-based particles can reduce ignition delay time, increase flame speed, and raise flame temperature, which is significant for storing and transporting abundant energy.
COMBUSTION AND FLAME
(2023)
Article
Materials Science, Multidisciplinary
Wenjin Zeng, Chaochao Yuan, Yuting Shi, Enzhi Li, Wei Hua, Qiaoli Niu, Kasim Ocakoglu, Ruidong Xia, Yong Min
Summary: The additive AO can improve the quality of the FASnI3 perovskite film by suppressing defects and increasing crystal grain size, resulting in higher photovoltaic conversion efficiency and stability.
ORGANIC ELECTRONICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sifa Dogan, Mine Ince, Fatma Sogutlu, Cigir Biray Avci, Derya Ozel, Fatma Yurt
Summary: This study investigates the efficacy of photodynamic therapy (PDT) on triple-negative breast cancer (TNBC) cells and finds that PDT can effectively reduce the survival ability of TNBC cells and induce their apoptosis. The activation of phthalocyanine derivative with specific dose of red light enhances the effect of PDT.
Article
Chemistry, Physical
Aslihan Uzun, Adem Sengul, Fatma Yurt
Summary: This study aims to find a cheaper and more accessible alternative to CyberKnife for the treatment of trigeminal neuralgia. Retrospective analysis of tomography images of 20 patients treated with CyberKnife was conducted, comparing treatment plans on Tomotherapy and Versa HD devices. Evaluation was done on the doses received by the target volume and critical organs, as well as the doses in healthy tissue. Versa HD stood out in terms of maximum doses of optical structures.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Fatma Yurt, Derya Ozel, Ayca Tuncel, Ozde Gokbayrak, Safiye Aktas
Summary: Triple-negative breast cancer (TNBC) is more aggressive compared to other breast cancer subtypes because of the lack of receptors and limited targeting therapy. Nanotechnology has allowed the development of various nanoparticle platforms for targeted cancer treatment. In this study, HSA-NPs encapsulated with docetaxel (DTX) and functionalized with polyethylene glycol (PEG) and durvalumab (DVL) were used to target TNBC cells. The results showed that the HSA-DTX@PEG-DVL NPs exhibited better cytotoxicity than DTX alone in all three cell lines.
Article
Energy & Fuels
Ridvan Kucukosman, Ahmet Alper Yontar, Kasim Ocakoglu
Summary: This study investigated the combustion and atomization behaviors of various types of alcohols, ketones, alkanes, esters, methyl benzenes, and ethers. The experiments were conducted by suspending fuel droplets on a ceramic wire and analyzing the ignition process. The results showed that the flame of oxygenated fuel droplets had a high non-luminous region throughout combustion, and the diameter reduction of the droplets followed the D2-law. Hexane, diethyl ether, and ethyl acetate had the shortest extinction times among the fuels studied here.
JOURNAL OF THE ENERGY INSTITUTE
(2023)
Article
Medicine, General & Internal
Fadime Aydin Kose, Ismail Ozturk, Seden Cin, Sura Baykan
Summary: This study is the first detailed investigation of the antioxidant and cytotoxic properties of the endemic Marrubium rotundifolium, with particular emphasis on the methanol extract, which showed high activity in both antioxidant and cytotoxic assays.
EUROPEAN JOURNAL OF THERAPEUTICS
(2022)
