Integration of Precipitation Kinetics From an In Vitro, Multicompartment Transfer System and Mechanistic Oral Absorption Modeling for Pharmacokinetic Prediction of Weakly Basic Drugs

Published 2018 View Full Article

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Title
Integration of Precipitation Kinetics From an In Vitro, Multicompartment Transfer System and Mechanistic Oral Absorption Modeling for Pharmacokinetic Prediction of Weakly Basic Drugs
Authors
Keywords
dissolution, dissolution model(s), in vitro, model(s), precipitation, bioavailability, oral absorption, pharmacokinetics, GastroPlus modeling, solubility, simulation(s)
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 108, Issue 1, Pages 574-583
Publisher
Elsevier BV
Online
2018-11-03
DOI
10.1016/j.xphs.2018.10.051

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