Two compartment pharmacokinetic model describes the intra-articular delivery and retention of rhprg4 following ACL transection in the Yucatan mini pig

Microscale frictional strains determine chondrocyte fate in loaded cartilage

(2018) Edward D. Bonnevie et al.   JOURNAL OF BIOMECHANICS

Proteoglycan 4 and hyaluronan as boundary lubricants for model contact lens hydrogels

(2017) Michael Samsom et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants

(2017) Katherine M. Larson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Early genetic restoration of lubricin expression in transgenic mice mitigates chondrocyte peroxynitrite release and caspase-3 activation

(2017) K.M. Larson et al.   OSTEOARTHRITIS AND CARTILAGE

Lubricin/proteoglycan 4 increases in both experimental and naturally occurring equine osteoarthritis

(2017) H.L. Reesink et al.   OSTEOARTHRITIS AND CARTILAGE

A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear

(2016) Christian Lattermann et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Arthroscopic irrigation of the bovine stifle joint increases cartilage surface friction and decreases superficial zone lubricin

(2016) Erin Teeple et al.   JOURNAL OF BIOMECHANICS

Electrokinetic Properties of Lubricin Antiadhesive Coatings in Microfluidic Systems

(2016) George W. Greene et al.   LANGMUIR

Allometric scaling for implementation of sustained release intra-articular medications–a pilot study

(2016) M. Hurtig et al.   OSTEOARTHRITIS AND CARTILAGE

Projecting Lifetime Risk of Symptomatic Knee Osteoarthritis and Total Knee Replacement in Individuals Sustaining a Complete Anterior Cruciate Ligament Tear in Early Adulthood

(2016) Lisa G. Suter et al.   ARTHRITIS CARE & RESEARCH

Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro

(2016) S.M. Iqbal et al.   Scientific Reports

Synthesis and characterization of a lubricin mimic (mLub) to reduce friction and adhesion on the articular cartilage surface

(2015) Alexandra Lawrence et al.   BIOMATERIALS

Lubricin: A versatile, biological anti-adhesive with properties comparable to polyethylene glycol

(2015) George W. Greene et al.   BIOMATERIALS

Effects of lubricant and autologous bone marrow stromal cell augmentation on immobilized flexor tendon repairs

(2015) Chunfeng Zhao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Anti-Lubricin Monoclonal Antibodies Created Using Lubricin-Knockout Mice Immunodetect Lubricin in Several Species and in Patients with Healthy and Diseased Joints

(2015) Minrong Ai et al.   PLoS One

The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid

(2015) Ali Alquraini et al.   ARTHRITIS RESEARCH & THERAPY

Mechanical Loading of Cartilage Explants with Compression and Sliding Motion Modulates Gene Expression of Lubricin and Catabolic Enzymes

(2015) Oliver R. Schätti et al.   Cartilage

Elastoviscous Transitions of Articular Cartilage Reveal a Mechanism of Synergy between Lubricin and Hyaluronic Acid

(2015) Edward D. Bonnevie et al.   PLoS One

Targeting Nerve Growth Factor (NGF) for Pain Management: What Does the Future Hold for NGF Antagonists?

(2014) Bernard Bannwarth et al.   DRUGS

Technical note: Three-dimensional imaging of rumen tissue for morphometric analysis using micro-computed tomography

(2014) M.A. Steele et al.   JOURNAL OF DAIRY SCIENCE

Synergistic Interactions between Grafted Hyaluronic Acid and Lubricin Provide Enhanced Wear Protection and Lubrication

(2013) Saurabh Das et al.   BIOMACROMOLECULES

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis

(2013) K. A. Waller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis

(2013) M. Z. C. Ruan et al.   Science Translational Medicine

Disposition of Human Recombinant Lubricin in Naive Rats and in a Rat Model of Post-traumatic Arthritis After Intra-articular or Intravenous Administration

(2012) Yulia Vugmeyster et al.   AAPS Journal

Effect of Tibial Plateau Fracture on Lubrication Function and Composition of Synovial Fluid

(2012) Brooke L Ballard et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Anti-NGF painkillers back on track?

(2012) David Holmes   NATURE REVIEWS DRUG DISCOVERY

The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection

(2012) K.A. Elsaid et al.   OSTEOARTHRITIS AND CARTILAGE

Intensity-dependent effect of treadmill running on lubricin metabolism of rat articular cartilage

(2012) Guo-Xin Ni et al.   ARTHRITIS RESEARCH & THERAPY

Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection

(2011) Gregory D. Jay et al.   ARTHRITIS AND RHEUMATISM

Post-traumatic osteoarthritis: Improved understanding and opportunities for early intervention

(2011) Donald D. Anderson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Boundary Lubrication of Chemically Grafted and Cross-Linked Hyaluronic Acid in Phosphate Buffered Saline and Lipid Solutions Measured by the Surface Forces Apparatus

(2011) Jing Yu et al.   LANGMUIR

Effects of Supplemental Intra-articular Lubricin and Hyaluronic Acid on the Progression of Posttraumatic Arthritis in the Anterior Cruciate Ligament–Deficient Rat Knee

(2010) Erin Teeple et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection

(2010) Gregory D. Jay et al.   ARTHRITIS AND RHEUMATISM

The glycosylation of human synovial lubricin: implications for its role in inflammation

(2010) Ruby P. Estrella et al.   BIOCHEMICAL JOURNAL

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin

(2009) Carl R. Flannery et al.   ARTHRITIS AND RHEUMATISM

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfaces

(2009) Debby P. Chang et al.   Soft Matter

The biomechanics of osteoarthritis: Implications for therapy

(2009) Joel A. Block et al.   Current Rheumatology Reports

Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury

(2008) K. A. Elsaid et al.   ARTHRITIS AND RHEUMATISM

Regulation of the friction coefficient of articular cartilage by TGF-β1 and IL-1β

(2008) Grayson DuRaine et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Conformational Mechanics, Adsorption, and Normal Force Interactions of Lubricin and Hyaluronic Acid on Model Surfaces†

(2008) Debby P. Chang et al.   LANGMUIR

The Symptoms of Osteoarthritis and the Genesis of Pain

(2008) David J. Hunter et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Molecular Aspects of Boundary Lubrication by Human Lubricin:  Effect of Disulfide Bonds and Enzymatic Digestion†

(2007) Bruno Zappone et al.   LANGMUIR