Article
Biology
Hytham N. Fageeh, Hammam Ibrahim Fageeh, Samar Saeed Khan, Prabhadevi C. Maganur, Nishant Vyas, Vikrant R. Patil, A. Thirumal Raj, Hosam Ali Baeshen, Shankargouda Patil
Summary: This study aimed to characterize monocytes isolated from the gingival crevicular fluid (GCF) in patients with periodontitis, evaluating cytokine levels, gene expression, and secreted cytokines and chemokines. CD14+ monocytes from GCF secreted higher levels of CCL2 and expressed genes responsible for monocyte migration, indicating their role in the inflammatory microenvironment of periodontitis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Hikaru Tamura, Toshihito Isono, Satoru Hirayama, Karin Sasagawa, Fumio Takizawa, Koichi Tabeta, Yutaka Terao
Summary: This study reveals the mechanisms by which neutrophil elastase (NE) exacerbates periodontitis. NE induces increased neutrophil recruitment and activity in the periodontal tissue, leading to worsened periodontal bone loss. Administration of an NE inhibitor reduces NE activity and attenuates periodontal bone loss. NE also promotes bacterial invasion in periodontal tissues by cleaving cell adhesion molecules and disrupting the gingival epithelial barrier.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nil Yakar, Gulnur Emingil, Asena Turedi, Cagdas Sahi, Timur Kose, Nagihan Bostanci, Angelika Silbereisen
Summary: This study aimed to investigate the association of GCF TREM-1, PGLYRP1, and IL-1 β levels with periodontal health in pre- and postmenopausal women. The results showed that there were no significant differences in GCF levels of TREM-1, PGLYRP1, and IL-1 β between pre- and postmenopausal women. However, higher GCF TREM-1 levels were observed in women with periodontitis, indicating that TREM-1 may be an indicator for periodontitis in both pre- and postmenopausal women.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Javier Fernandez, Constanza Jimenez, Dafna Benadof, Paulina Morales, Jessica Astorga, Felipe Caceres, Marcela Hernandez, Alejandra Fernandez, Fernando Valenzuela
Summary: The study aimed to evaluate the levels of MMP-2 and MMP-9 in gingival crevicular fluid as novel biomarkers for rosacea. The results showed a significant increase in MMP-9 concentration in the GCF of patients with rosacea compared to healthy patients. MMP-9 levels can be used as a diagnostic biomarker for rosacea.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Berkay Gur, Beral Afacan, Ozge Cevik, Timur Kose, Gulnur Emingil
Summary: This study aimed to evaluate the levels of PLAP-1, sclerostin, and TNF-alpha in gingival crevicular fluid (GCF) of individuals with periodontal disease. The results showed significantly higher levels of PLAP-1, sclerostin, and TNF-alpha in the periodontitis group compared to the gingivitis and periodontally healthy groups. The study suggests that PLAP-1 and sclerostin may be involved in the pathogenesis of periodontal disease.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Buket Acar, Ersin Gumus, Selcen Ozcan-Bulut, Cansu Ozsin-Ozler, Meryem Seda Boyraz, Cagman Tan, Ismail Yaz, Begum Ozbek, Deniz Cagdas, Inci Nur Saltik-Temizel, Hulya Demir, Hasan Ozen, Erdem Karabulut, Ilhan Tezcan, Aysel Yuce, Ezel Berker
Summary: The cytokine profile in gingival crevicular fluid and serum of pediatric inflammatory bowel disease (IBD) patients was evaluated, with 50 IBD patients and 21 healthy children enrolled in the study. Patients with IBD were categorized into subgroups based on disease activity and response to treatment, and the levels of pro- and anti-inflammatory cytokines were measured. Results showed that disease activity might impact gingival inflammation in pediatric patients with IBD due to increased cytokine interactions and severity of inflammation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Maria K. Soderlin, Gosta Rutger Persson, Stefan Renvert, Johan Sanmartin Berglund
Summary: In this population-based elderly RA cohort, neither pro-inflammatory nor anti-inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Simina Chelarescu, Petra Surlin, Mioara Decusara, Madalina Oprica, Eugen Bud, Elina Teodorescu, Mahmoud Nabil Elsaafin, Mariana Pacurar
Summary: The study found that adolescents' periodontal tissues are more responsive to orthodontic forces during treatment. There was a significant increase in IL1 beta and IL6 levels in the gingival crevicular fluid.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ayaz Enver, Nurdan Ozmeric, Sila Cagri Isler, Murat Toruner, Cigdem Fidan, Gulsah Demirci, Serenay Elgun, Andre Paes B. da Silva
Summary: This study aimed to evaluate the levels of cytokines in saliva and gingival crevicular fluid (GCF) in patients with ulcerative colitis (UC), Crohn disease (CD), and non-IBD, and analyze their associations with periodontal conditions. The study found that UC and CD patients with periodontitis and gingivitis had higher levels of TNF-alpha and lower levels of IL-10 compared to non-IBD patients. Additionally, UC patients with periodontitis had higher scores of bleeding on probing and increased levels of IL-1 beta in saliva and GCF compared to CD patients. The study concluded that in the presence of periodontal diseases, UC and CD patients showed different expression levels of TNF-alpha, IL-1 beta, and IL-10 in oral secretions compared to non-IBD patients.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Luigi Nibali, Abish Stephen, Eleni Hagi-Pavli, Robert Allaker, Antonino Di Pino, Valentina Terranova, Marcella Pisano, Salvatore Di Marca, Viviana Ferrara, Roberto Scicali, Mauro Giordano, Francesco Purrello, Nikolaos Donos, Lorenzo Malatino
Summary: The study suggests that GCF markers in patients with metabolic syndrome may be associated with concomitant periodontitis, particularly the levels of markers such as Aggrecan, IL-6, and IL-8 are correlated with the severity of the disease.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bardia Vadiati Saberi, Farouq Yousefi, Tooba Yousefi, Durdi Qujeq
Summary: This study determined the correlation between mucin and alpha-amylase protein levels in gingival crevicular fluid (GCF) with chronic periodontitis. The results showed that the levels of both markers were higher in patients with chronic periodontitis compared to successfully recovered patients, suggesting that they could be used to determine the activity of periodontal disease.
Article
Health Care Sciences & Services
Hammam Ibrahim Fageeh, Hytham N. Fageeh, Shankargouda Patil
Summary: Periodontitis is an inflammatory condition caused by pathogenic bacteria in dental plaque. Macrophages derived from monocytes play a dual role in periodontitis, presenting antigens to lymphocytes while also contributing to periodontal destruction. The study found that GCF samples from periodontitis patients have higher levels of specific cytokines, and that treatment with these samples can induce monocytes to differentiate into destructive macrophages, affecting the phenotype and function of resident cells in the periodontium.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemical Research Methods
Xin Zhang, Xiaoping Xiao, Yue Mu, Yao Ran Liu, Xinxin Lin, Qian Li, Wei Sun
Summary: This study investigated the influence of tooth site, sex, and age on the normal GCF proteome in periodontal health. Results showed that tooth site had a small impact, while sex and age were important factors affecting the GCF proteome, with sex having a significant influence on young adults.
JOURNAL OF PROTEOMICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Cavid Mammadov, Muhittin A. Serdar, Meral Gunhan
Summary: This study aimed to evaluate the levels of ADMA, SDMA, and IL-1 beta in GCF from periodontitis patients. The results showed that the levels of IL-1 beta, ADMA, and SDMA in GCF were significantly higher in periodontitis patients compared to the control group, and they were positively correlated with clinical periodontal parameters. It suggests that ADMA and SDMA may be involved in the pathogenesis of periodontal disease.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Microbiology
Simran Preet Bhalla, Ann Maria Shaju, Carlos Marcelo da Silva Figueredo, Leticia Algarves Miranda
Summary: C5a levels were significantly increased in both gingival crevicular fluid and saliva of patients with periodontal disease, indicating a potential role of this molecule in the pathogenesis of the disease.
Article
Dentistry, Oral Surgery & Medicine
Viveca Wallin Bengtsson, G. Rutger Persson, Johan Berglund, Stefan Renvert
CLINICAL ORAL INVESTIGATIONS
(2019)
Article
Dentistry, Oral Surgery & Medicine
Mohammad Alotaibi, Gary Moran, Brendan Grufferty, Stefan Renvert, Ioannis Polyzois
ACTA ODONTOLOGICA SCANDINAVICA
(2019)
Article
Dentistry, Oral Surgery & Medicine
Chin-Wei Wang, Stefan Renvert, Hom-Lay Wang
Article
Dentistry, Oral Surgery & Medicine
Hideaki Hirooka, Stefan Renvert
Article
Dentistry, Oral Surgery & Medicine
Lewis Winning, Ioannis Polyzois, Johan Sanmartin Berglund, Stefan Renvert
JOURNAL OF CLINICAL PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Cecilia Widen, Helene Holmer, Susanna Sattlin, Stefan Renvert, Ake Lernmark, G. Rutger Persson
JOURNAL OF PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Ahmad Aghazadeh, Rutger G. Persson, Stefan Renvert
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Giovanni Serino, Masahiro Wada, Tomoaki Mameno, Stefan Renvert
Summary: Most implants remained healthy following surgery, but those with residual pockets may progress further. Presence of pockets around the circumference of implants is a risk factor for disease progression.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Viveca Wallin Bengtsson, Gosta Rutger Persson, Johan Sanmartin Berglund, Stefan Renvert
Summary: Individuals with periodontitis have a higher risk of developing ischemic heart diseases and death in this 17-year follow-up study. The association between periodontitis and incidence of ischemic heart disease was particularly notable in women and older individuals. Additionally, periodontitis was more prevalent among men and was associated with mortality in all individuals, particularly in younger age groups.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Stefan Renvert, Jean-Louis Giovannoli, Ann-Marie Roos-Jansaker, Sven Rinke
Summary: The use of DBBM and NBCM in addition to surgical debridement led to significantly more defect fill compared to debridement alone, but there were no significant differences in other clinical parameters or patient-reported outcomes between the two groups.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ahmad Aghazadeh, G. Rutger Persson, Andreas Stavropoulos, Stefan Renvert
Summary: This study assessed the long-term efficacy of reconstructive treatment of peri-implant intraosseous defects, and the results showed that using bovine-derived xenograft (BDX) resulted in more predictable outcomes over 5 years compared to autogenous bone graft (AB).
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sara Henricsson, Viveca Wallin Bengtsson, Stefan Renvert, Johan Sanmartin Berglund, Nina Lundegren, Pia Andersson
Summary: The study aimed to compare self-perceived oral health and orofacial appearance in three different cohorts of 60-year-old individuals. Data from the Swedish National Study of Aging and Care were analyzed, and a cross-sectional design was used. The results showed that the participants reported a low number of self-perceived problems with oral health. However, a higher proportion in the 2014-2015 cohort experienced problems with bleeding gums. Overall, the 60-year-olds irrespective of birth cohort perceived their oral health and orofacial appearance as satisfactory.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Stefan Renvert, Michael J. Noack, Christophe Lequart, Silvia Roldan, Marja L. Laine
CLINICAL COSMETIC AND INVESTIGATIONAL DENTISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Sven Rinke, Marc Nordlohne, Andreas Leha, Stefan Renvert, Gerhard Schmalz, Dirk Ziebolz
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2020)
Meeting Abstract
Rheumatology
Anna Svard, Stefan Renvert, Johan Berglund, Maria Soderlin
ANNALS OF THE RHEUMATIC DISEASES
(2019)