High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation

Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons

(2013) Ruishan Wang et al.   Cell Metabolism

Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2013) Masato Maesako et al.   PLoS One

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

(2013) Y. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Itinerary of Internalised β-Secretase, BACE1, and Its Potential Impact on β-Amyloid Peptide Biogenesis

(2013) Pei Zhi Cheryl Chia et al.   TRAFFIC

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

(2012) Yogikala Prabhu et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamin 1 Regulates Amyloid Generation through Modulation of BACE-1

(2012) Li Zhu et al.   PLoS One

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

(2011) Masato Maesako et al.   NEUROBIOLOGY OF AGING

Midlife overweight and obesity increase late-life dementia risk: A population-based twin study

(2011) W. L. Xu et al.   NEUROLOGY

Glucose tolerance status and risk of dementia in the community: The Hisayama Study

(2011) T. Ohara et al.   NEUROLOGY

Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage

(2011) M. Maesako et al.   NEUROSCIENCE

Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-Fat Diet in APP23 Mice

(2010) N. F. Fitz et al.   JOURNAL OF NEUROSCIENCE

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

Exacerbation of poststroke dementia by type 2 diabetes is associated with synergistic increases of β-secretase activation and β-amyloid generation in rat brains

(2009) T. Zhang et al.   NEUROSCIENCE

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

(2008) Lakshmi Thirumangalakudi et al.   JOURNAL OF NEUROCHEMISTRY

N-cadherin-based adhesion enhances Aβ release and decreases Aβ42/40ratio

(2008) Kengo Uemura et al.   JOURNAL OF NEUROCHEMISTRY

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING