Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence

Exploring the role of the HNF-1αG319S polymorphism in β cell failure and youth-onset type 2 diabetes: Lessons from MODY and Hnf-1α-deficient animal models

(2015) Michael E. Jonasson et al.   Biochemistry and Cell Biology

Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation

(2014) Corina Lesseur et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity

(2014) Maria Z. Alfaradhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Molecular mechanisms of diabetic cardiomyopathy

(2014) Heiko Bugger et al.   DIABETOLOGIA

Maternal Diet-induced Obesity Programs Cardiovascular Dysfunction in Adult Male Mouse Offspring Independent of Current Body Weight

(2014) Heather L. Blackmore et al.   ENDOCRINOLOGY

Effects of pregnancy on obesity-induced inflammation in a mouse model of fetal programming

(2014) C Ingvorsen et al.   INTERNATIONAL JOURNAL OF OBESITY

Effect of Dietaryn-3Polyunsaturated Fatty Acids on Oxidant/Antioxidant Status in Macrosomic Offspring of Diabetic Rats

(2014) B. Guermouche et al.   Biomed Research International

Maternal chocolate and sucrose soft drink intake induces hepatic steatosis in rat offspring associated with altered lipid gene expression profile

(2013) M. Kjaergaard et al.   Acta Physiologica

Intracellular lipid content is a key intrinsic determinant for hepatocyte viability and metabolic and inflammatory states in mice

(2013) Liang Sheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice

(2013) E. Isganaitis et al.   DIABETES

Earlier Onset of Complications in Youth With Type 2 Diabetes

(2013) A. B. Dart et al.   DIABETES CARE

Maternal Obesity Enhances White Adipose Tissue Differentiation and Alters Genome-Scale DNA Methylation in Male Rat Offspring

(2013) Sarah J. Borengasser et al.   ENDOCRINOLOGY

Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice

(2013) Angelina Mouralidarane et al.   HEPATOLOGY

Experimental Hyperleptinemia in Neonatal Rats Leads to Selective Leptin Responsiveness, Hypertension, and Altered Myocardial Function

(2013) Anne-Maj Samuelsson et al.   HYPERTENSION

Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism

(2013) C C Vega et al.   INTERNATIONAL JOURNAL OF OBESITY

Maternal Exercise Improves Insulin Sensitivity in Mature Rat Offspring

(2013) LINDSAY G. CARTER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic Overactivity

(2013) Maria Paola Canale et al.   International Journal of Endocrinology

Perinatal exercise improves glucose homeostasis in adult offspring

(2012) Lindsay G. Carter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Maternal High-Fat Diet During Gestation or Suckling Differentially Affects Offspring Leptin Sensitivity and Obesity

(2012) B. Sun et al.   DIABETES

Placental Adiponectin Gene DNA Methylation Levels Are Associated With Mothers’ Blood Glucose Concentration

(2012) Luigi Bouchard et al.   DIABETES

Metabolic Consequences of Hepatic Steatosis in Overweight and Obese Adolescents

(2012) B. A. Wicklow et al.   DIABETES CARE

High Burden of Kidney Disease in Youth-Onset Type 2 Diabetes

(2012) A. B. Dart et al.   DIABETES CARE

The Programming of Cardiac Hypertrophy in the Offspring by Maternal Obesity Is Associated with Hyperinsulinemia, AKT, ERK, and mTOR Activation

(2012) Denise S. Fernandez-Twinn et al.   ENDOCRINOLOGY

Exercise Training Attenuates Placental Ischemia-Induced Hypertension and Angiogenic Imbalance in the Rat

(2012) Jeffrey S. Gilbert et al.   HYPERTENSION

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

(2012) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interaction between maternal and postnatal high fat diet leads to a greater risk of myocardial dysfunction in offspring via enhanced lipotoxicity, IRS-1 serine phosphorylation and mitochondrial defects

(2012) Subat Turdi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Maternal obesity, lipotoxicity and cardiovascular diseases in offspring

(2012) Maolong Dong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Intrahepatic Fat Is Increased in the Neonatal Offspring of Obese Women with Gestational Diabetes

(2012) David E. Brumbaugh et al.   JOURNAL OF PEDIATRICS

Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth

(2012) Fredrick J Rosario et al.   JOURNAL OF PHYSIOLOGY-LONDON

Wild-type offspring of heterozygous prolactin receptor-null female mice have maladaptive β-cell responses during pregnancy

(2012) Carol Huang   JOURNAL OF PHYSIOLOGY-LONDON

Gestational diabetes mellitus: risks and management during and after pregnancy

(2012) Thomas A. Buchanan et al.   Nature Reviews Endocrinology

Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition

(2012) M. J. J. Ronis et al.   PHYSIOLOGICAL GENOMICS

Parental Diabetes: The Akita Mouse as a Model of the Effects of Maternal and Paternal Hyperglycemia in Wildtype Offspring

(2012) Corinna Grasemann et al.   PLoS One

Altered adipose tissue metabolism in offspring of dietary obese rat dams

(2011) Nassira Batoul Benkalfat et al.   CLINICAL SCIENCE

Metformin Therapy During Pregnancy: Good for the goose and good for the gosling too?

(2011) D. S. Feig et al.   DIABETES CARE

Metformin in Gestational Diabetes: The Offspring Follow-Up (MiG TOFU): Body composition at 2 years of age

(2011) J. A. Rowan et al.   DIABETES CARE

Maternal Diabetes Compromises the Organization of Hypothalamic Feeding Circuits and Impairs Leptin Sensitivity in Offspring

(2011) Sophie M. Steculorum et al.   ENDOCRINOLOGY

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

(2011) Mariel M Finucane et al.   LANCET

Epigenetics, the life-course and metabolic disease

(2011) Peter D. Gluckman   Nature Reviews Endocrinology

The Influence of Maternal Body Mass Index on Infant Adiposity and Hepatic Lipid Content

(2011) Neena Modi et al.   PEDIATRIC RESEARCH

Offspring of Mothers Fed a High Fat Diet Display Hepatic Cell Cycle Inhibition and Associated Changes in Gene Expression and DNA Methylation

(2011) Kevin J. Dudley et al.   PLoS One

The Early Origins of Cardiovascular Health and Disease: Who, When, and How

(2011) Christian Rueda-Clausen et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Metformin mitigates the impaired development of skeletal muscle in the offspring of obese mice

(2011) J F Tong et al.   Nutrition & Diabetes

Global prevalence and trends of overweight and obesity among preschool children

(2010) Mercedes de Onis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fetal origins of adult diabetes

(2010) Christina Kanaka-Gantenbein   Annals of the New York Academy of Sciences

Maternal Antioxidant Supplementation Prevents Adiposity in the Offspring of Western Diet-Fed Rats

(2010) S. Sen et al.   DIABETES

Type 2 Diabetes, Medication-Induced Diabetes, and Monogenic Diabetes in Canadian Children: A prospective national surveillance study

(2010) S. Amed et al.   DIABETES CARE

Animal Models in Diabetes and Pregnancy

(2010) Alicia Jawerbaum et al.   ENDOCRINE REVIEWS

Maternal Overweight Programs Insulin and Adiponectin Signaling in the Offspring

(2010) Kartik Shankar et al.   ENDOCRINOLOGY

Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart

(2010) Jingying Wang et al.   FASEB JOURNAL

Sex-specificity in transgenerational epigenetic programming

(2010) Gregory A. Dunn et al.   HORMONES AND BEHAVIOR

Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice

(2010) Jude A. Oben et al.   JOURNAL OF HEPATOLOGY

Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2010) Subat Turdi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

RAPID REPORT: Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats

(2010) E. Zambrano et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hepatic and very low-density lipoprotein fatty acids in obese offspring of overfed dams

(2010) Samira Bouanane et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Maternal high fat feeding and gestational dietary restriction: Effects on offspring body weight, food intake and hypothalamic gene expression over three generations in mice

(2010) Silvia Q. Giraudo et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes

(2010) Natalia Igosheva et al.   PLoS One

Altered hepatic insulin signalling in male offspring of obese mice

(2010) M. S. Martin-Gronert et al.   Journal of Developmental Origins of Health and Disease

The Impact of Nutritional Fatty Acids during Pregnancy and Lactation on Early Human Adipose Tissue Development

(2009) H. Hauner et al.   ANNALS OF NUTRITION AND METABOLISM

Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathways

(2009) Benjamin E Reinking et al.   Cardiovascular Diabetology

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Established diet-induced obesity in female rats leads to offspring hyperphagia, adiposity and insulin resistance

(2009) P. Nivoit et al.   DIABETOLOGIA

Maternal High-Fat Diet Promotes Body Length Increases and Insulin Insensitivity in Second-Generation Mice

(2009) Gregory A. Dunn et al.   ENDOCRINOLOGY

Up-Regulation of Toll-Like Receptor 4/Nuclear Factor-κB Signaling Is Associated with Enhanced Adipogenesis and Insulin Resistance in Fetal Skeletal Muscle of Obese Sheep at Late Gestation

(2009) Xu Yan et al.   ENDOCRINOLOGY

Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression

(2009) Kimberley D. Bruce et al.   HEPATOLOGY

Maternal metabolism and obesity: modifiable determinants of pregnancy outcome

(2009) S. M. Nelson et al.   HUMAN REPRODUCTION UPDATE

Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective

(2009) P D Gluckman et al.   INTERNATIONAL JOURNAL OF OBESITY

Overweight and the Metabolic Syndrome in Adult Offspring of Women with Diet-Treated Gestational Diabetes Mellitus or Type 1 Diabetes

(2009) Tine D. Clausen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gestational diabetes: the need for a common ground

(2009) E Albert Reece et al.   LANCET

High–saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL/6 mice

(2009) Chengya Liang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Maternal Obesity Induced by Diet in Rats Permanently Influences Central Processes Regulating Food Intake in Offspring

(2009) Shona L. Kirk et al.   PLoS One

The impact of diet during early life and its contribution to later disease: critical checkpoints in development and their long-term consequences for metabolic health

(2009) Michael E. Symonds et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Time course of changes in serum oxidant/antioxidant status in overfed obese rats and their offspring

(2008) Samira Bouanane et al.   CLINICAL SCIENCE

Maternal and Postnatal Overnutrition Differentially Impact Appetite Regulators and Fuel Metabolism

(2008) Hui Chen et al.   ENDOCRINOLOGY

Prolactin Receptor Is Required for Normal Glucose Homeostasis and Modulation of β-Cell Mass during Pregnancy

(2008) Carol Huang et al.   ENDOCRINOLOGY

Evidence that a maternal “junk food” diet during pregnancy and lactation can reduce muscle force in offspring

(2008) Stéphanie A. Bayol et al.   EUROPEAN JOURNAL OF NUTRITION

Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth

(2008) M J Morris et al.   INTERNATIONAL JOURNAL OF OBESITY

Offspring from mothers fed a ‘junk food’ diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females

(2008) S. A. Bayol et al.   JOURNAL OF PHYSIOLOGY-LONDON

Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet

(2008) G. J. Howie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity

(2008) Naoto Matsuzawa-Nagata et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hyperglycemia and Adverse Pregnancy Outcomes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Maternal obesity at conception programs obesity in the offspring

(2007) Kartik Shankar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia, Adiposity, Hypertension, and Insulin Resistance

(2007) Anne-Maj Samuelsson et al.   HYPERTENSION