The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury

Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils

(2017) Chunling Jiang et al.   JOURNAL OF IMMUNOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rab1 in cell signaling, cancer and other diseases

(2016) X-Z Yang et al.   ONCOGENE

Pathogenesis of Macrophage Activation Syndrome and Potential for Cytokine- Directed Therapies

(2015) Grant S. Schulert et al.   Annual Review of Medicine

Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier FunctionSignificance

(2015) Zhibo Yan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization

(2015) Ying-Cing Lin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

(2015) Junghyung Park et al.   NEUROSCIENCE LETTERS

A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling

(2015) Heide Christine Patterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas

(2015) Claudia R Oliva et al.   Oncotarget

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation

(2015) Prajwal Gurung et al.   Scientific Reports

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Differential Role for p120-Catenin in Regulation of TLR4 Signaling in Macrophages

(2014) Zhiyong Yang et al.   JOURNAL OF IMMUNOLOGY

Activation of NLRP3 Inflammasome in Alveolar Macrophages Contributes to Mechanical Stretch-Induced Lung Inflammation and Injury

(2013) J. Wu et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Cytochrome c oxidase dysfunction in oxidative stress

(2012) Satish Srinivasan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Acute Respiratory Distress Syndrome

(2012)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Period of Irreversible Therapeutic Intervention during Sepsis Correlates with Phase of Innate Immune Dysfunction

(2012) David M. Cauvi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR4-Mediated AKT Activation Is MyD88/TRIF Dependent and Critical for Induction of Oxidative Phosphorylation and Mitochondrial Transcription Factor A in Murine Macrophages

(2012) C. P. Bauerfeld et al.   JOURNAL OF IMMUNOLOGY

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes

(2010) Harald Husebye et al.   IMMUNITY

Acquisition of Temozolomide Chemoresistance in Gliomas Leads to Remodeling of Mitochondrial Electron Transport Chain

(2010) Claudia R. Oliva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Integrin β1 Recycling to Lipid Rafts by Rab1a to Promote Cell Migration

(2010) Chenran Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane

(2010) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagosome Formation Depends on the Small GTPase Rab1 and Functional ER Exit Sites

(2010) Felipe Carlos Martín Zoppino et al.   TRAFFIC

Mechanisms of interleukin-1β release

(2009) Claudia Eder   IMMUNOBIOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme

(2008) L. Verstrepen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interleukin-1β Causes Acute Lung Injury via αvβ5 and αvβ6 Integrin–Dependent Mechanisms

(2008) Michael T. Ganter et al.   CIRCULATION RESEARCH