Mitochondria and NMDA Receptor-Dependent Toxicity of Berberine Sensitizes Neurons to Glutamate and Rotenone Injury

Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid

(2014) Chandraiah Godugu et al.   PLoS One

Neurotoxic effects of berberine on long-term l-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson’s disease

(2013) Keon Sung Shin et al.   ARCHIVES OF PHARMACAL RESEARCH

Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1

(2013) Jinbum Bae et al.   MOLECULES AND CELLS

Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth

(2013) Ya-Yun Hsu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia

(2012) Q. Zhang et al.   ACTA PHYSIOLOGICA HUNGARICA

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling

(2012) Kai Kysenius et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells

(2012) Ya-Yun Hsu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials

(2012) Giuseppe Derosa et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Microembolism, silent brain infarcts and dementia

(2012) I. Goldberg et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

(2012) Siva Sundara Kumar Durairajan et al.   NEUROBIOLOGY OF AGING

Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

(2012) Lihong Wang et al.   PLoS One

Rapid generation of mitochondrial superoxide induces mitochondrion-dependent but caspase-independent cell death in hippocampal neuronal cells that morphologically resembles necroptosis

(2012) Masayuki Fukui et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Expression of GluK1c underlies the developmental switch in presynaptic kainate receptor function

(2012) Aino Vesikansa et al.   Scientific Reports

Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent

(2011) DJ Hausenloy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease

(2011) Hong-Fang Ji et al.   MOLECULES

Berberine-induced Haemolysis Revisited: Safety of Rhizoma coptidis and Cortex phellodendri in Chronic Haematological Diseases

(2011) Yeh-ching Linn et al.   PHYTOTHERAPY RESEARCH

Effect of Berberine on Cell Survival in the Developing Rat Brain Damaged by MK-801

(2011) Taehwan Lee et al.   Experimental Neurobiology

Oxidative Stress and Energy Crises in Neuronal Dysfunction

(2010) David G. Nicholls   Annals of the New York Academy of Sciences

Identification of the toxic constituents in Rhizoma Coptidis

(2010) Bing-Liang Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research

(2010) Minzhong Ye et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease

(2010) Ik Hyun Kwon et al.   NEUROSCIENCE LETTERS

Berberine reduces the hypoxic-ischemic insult in rat pup brain

(2009) F. Benaissa et al.   ACTA PHYSIOLOGICA HUNGARICA

Berberine Exerts Neuroprotective Actions against in Vitro Ischemia-Induced Neuronal Cell Damage in Organotypic Hippocampal Slice Cultures: Involvement of B-Cell Lymphoma 2 Phosphorylation Suppression

(2009) Hu-Shan Cui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids

(2009) Hyun Ah Jung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

(2008) N. Turner et al.   DIABETES

Neuroprotective effects of berberine on stroke models in vitro and in vivo

(2008) Xi-Qiao Zhou et al.   NEUROSCIENCE LETTERS

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

(2008) Mohsen Imanshahidi et al.   PHYTOTHERAPY RESEARCH

Mechanisms of Berberine (Natural Yellow 18)–Induced Mitochondrial Dysfunction: Interaction with the Adenine Nucleotide Translocator

(2008) Cláudia V. Pereira et al.   TOXICOLOGICAL SCIENCES