TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1–Mediated Inactivation of LCK

Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells

(2018) Zhigang Li et al.   JOURNAL OF IMMUNOLOGY

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

(2017) Adrian Britschgi et al.   NATURE

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

(2017) Sanae Ben Mkaddem et al.   Nature Communications

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

SHP-1: the next checkpoint target for cancer immunotherapy?

(2016) H. Angharad Watson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection

(2016) Ryan J. Martinez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders

(2016) Yadhu Sharma et al.   IMMUNOLOGIC RESEARCH

The phosphoproteome of human Jurkat T cell clones upon costimulation with anti-CD3/anti-CD28 antibodies

(2016) Tien Dung Nguyen et al.   Journal of Proteomics

Characterization of Hippo Pathway Components by Gene Inactivation

(2016) Steven W. Plouffe et al.   MOLECULAR CELL

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1

(2016) Eri Ishikawa et al.   Nature Communications

THEMIS: a critical TCR signal regulator for ligand discrimination

(2015) Nicholas RJ Gascoigne et al.   CURRENT OPINION IN IMMUNOLOGY

Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation

(2015) Yun Xiao et al.   JOURNAL OF IMMUNOLOGY

An optimized method for high-titer lentivirus preparations without ultracentrifugation

(2015) Wei Jiang et al.   Scientific Reports

Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors

(2014) E. K. Moon et al.   CLINICAL CANCER RESEARCH

A THEMIS:SHP1 complex promotes T-cell survival

(2014) W. Paster et al.   EMBO JOURNAL

Modulation of T Cell Activation by Stomatin-Like Protein 2

(2014) M. G. Kirchhof et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation Site Dynamics of Early T-cell Receptor Signaling

(2014) Lily A. Chylek et al.   PLoS One

Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection

(2013) Michael Freeley et al.   BIOCHEMICAL JOURNAL

Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau Protein and Are Activated in Tangle-bearing Neurons in Alzheimer Disease

(2013) Ignatius A. Tavares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SHP-1 phosphatase activity counteracts increased T cell receptor affinity

(2013) Michael Hebeisen et al.   JOURNAL OF CLINICAL INVESTIGATION

Shp1 regulates T cell homeostasis by limiting IL-4 signals

(2013) Dylan J. Johnson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation

(2013) A. Stirnweiss et al.   Science Signaling

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

(2012) Etienne Gagnon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial and Plasma Membrane Pools of Stomatin-Like Protein 2 Coalesce at the Immunological Synapse during T Cell Activation

(2012) Darah A. Christie et al.   PLoS One

How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism

(2012) Jérémie Rossy et al.   Frontiers in Immunology

ARID1A, a Factor That Promotes Formation of SWI/SNF-Mediated Chromatin Remodeling, Is a Tumor Suppressor in Gynecologic Cancers

(2011) B. Guan et al.   CANCER RESEARCH

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

(2009) Ulrike Lorenz   IMMUNOLOGICAL REVIEWS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

siRNA stabilization prolongs gene knockdown in primary T lymphocytes

(2008) Andrej Mantei et al.   EUROPEAN JOURNAL OF IMMUNOLOGY