Article
Materials Science, Multidisciplinary
Tun Naw Sut, Elba R. Valle-Gonzalez, Bo Kyeong Yoon, Soohyun Park, Joshua A. Jackman, Nam-Joon Cho
Summary: Lipid bicelles have the potential to be designed as functional nanostructures with membrane-disruptive properties for anti-infective applications.
APPLIED MATERIALS TODAY
(2021)
Article
Nanoscience & Nanotechnology
Lorena Simon-Gracia, Pablo Scodeller, William S. Fisher, Valeria Sidorenko, Victoria M. Steffes, Kai K. Ewert, Cyrus R. Safinya, Tambet Teesalu
Summary: Novel lipid-based carriers (CLsPTX and nanodiscsPTX) with improved pharmacokinetics and therapeutic efficacy can be achieved by increasing the PEG coverage. The addition of a cone-shaped PEG-lipid promotes the formation of PEGylated CLsPTX and PTX-containing fluid lipid nanodiscs, showing significantly enhanced cellular uptake and cytotoxicity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Public, Environmental & Occupational Health
V. A. Leslie, Khaloud Mohammed Alarjani, Arunkumar Malaisamy, Balamuralikrishnan Balasubramanian
Summary: The study isolated a bacteriocin-producing strain Lactobacillus plantarum LA21 from the fermented food shidal, which showed antibacterial activity against pathogens, with the lowest minimum inhibitory concentration observed in Listeria monocytogenes. Additionally, molecular docking studies demonstrated relatively intense interactions between bacteriocins and their targets.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Food Science & Technology
Yan-Mei Zhang, Lin-Yu Yang, Jian-Ping Ying, Chao-Min Fu, Gang Wu, Xiao-Ran Li, Qi-Lin Zhang
Summary: Milk is prone to microbial contamination and spoilage, but lactic acid bacteria (LAB) bacteriocins have shown great potential in preserving food due to their antibacterial effects. This study purified and characterized a novel bacteriocin RSQ01 from Lactococcus lactis, which exhibited a broad-spectrum antimicrobial activity against both gram-positive and gram-negative bacteria. RSQ01 also maintained the nutritional composition, antioxidant parameters, and sensory properties of milk, and caused abundance changes in metabolomes, which contributed to the milk quality. Overall, this study highlights the potential of RSQ01 in milk preservation.
Article
Agriculture, Dairy & Animal Science
Yu-Hang Jiang, Wei-Gang Xin, Lin-Yu Yang, Jian-Ping Ying, Zi-Shun Zhao, Lian-Bing Lin, Xiu-Zhang Li, Qi-Lin Zhang
Summary: A novel LAB bacteriocin LSX01 isolated from traditional fermented yogurt in Yunnan, China was found to possess antibacterial and antibiofilm activity against Staphylococcus aureus, suggesting its potential in improving dairy product safety.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Microbiology
Longcheng Guo, Joseph Wambui, Chenhui Wang, Francis Muchaamba, Maria Victoria Fernandez-Cantos, Jaap Broos, Taurai Tasara, Oscar P. Kuipers, Roger Stephan
Summary: This study discovered a new variant of lantibiotic called cesin, which kills bacteria by inhibiting cell wall synthesis without pore formation. The lantibiotic demonstrated potent antimicrobial activity and stability, making it a potential antimicrobial compound for food and/or health applications.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Longcheng Guo, Joseph Wambui, Chenhui Wang, Francis Muchaamba, Maria Victoria Fernandez-Cantos, Jaap Broos, Taurai Tasara, Oscar P. Kuipers, Roger Stephan
Summary: Cesin, a novel variant of nisin, efficiently kills bacteria by inhibiting cell wall synthesis without pore formation. It demonstrates a broad and potent antimicrobial profile, attributed to lipid II binding and electrostatic interactions with teichoic acids. The stability tests show that cesin is highly stable under different environmental conditions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Materials Science, Multidisciplinary
Tun Naw Sut, Bo Kyeong Yoon, Won-Yong Jeon, Joshua A. Jackman, Nam-Joon Cho
Summary: Supported lipid bilayer (SLB) coatings, versatile cell-membrane-mimicking biointerfaces, have been expanded for medical and biotechnology applications, facilitating various studies and applications like biosensors, diagnostics, and antifouling surfaces.
APPLIED MATERIALS TODAY
(2021)
Article
Engineering, Environmental
Maryam Khalili Samani, Zahra Noormohammadi, Mohammad Reza Fazeli, Nasrin Samadi
Summary: This study investigated the antibacterial activity of Iranian honey from different regions, identifying Bacillus subtilis SB1 from Sabalan honey as a potent source of antibacterial compounds. Optimal conditions for bacteriocin production were found to be a yeast extract-based medium at 34 degrees C with near neutral pH. Production of antibacterial compounds in bioreactor was found to be more rapid than in shake flask.
JOURNAL OF ENVIRONMENTAL HEALTH SCIENCE AND ENGINEERING
(2021)
Article
Microbiology
Jessica Vaca, Aurelio Ortiz, Estibaliz Sansinenea
Summary: Antibiotic-resistant bacteria are a global threat, emphasizing the importance of developing new antibiotic substances. Bacillus is known for its production of a wide range of chemical compounds, including bacteriocins, which are small peptides with stable antibacterial activity in various pH and temperature conditions. This study aimed to isolate and compare the bacteriocins from three related species of B. cereus group and analyze their bactericidal activity. The results showed that bacteriocins can be distinguished based on the Bacillus species they are isolated from.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Food Science & Technology
Yan-Mei Zhang, Yu-Hang Jiang, Hong-Wei Li, Xiu-Zhang Li, Qi-Lin Zhang
Summary: S. argenteus is a pathogen that can cause food poisoning, and its biofilms pose a potential risk to food safety. This study introduces a novel bacteriocin, LSB1, derived from Lactobacillus plantarum CGMCC 1.12934, which exhibits strong antibacterial and antibiofilm activity against S. argenteus. LSB1 shows excellent stability and a wide antimicrobial spectrum, making it a potential natural food preservative.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Engineering, Environmental
Qikai Liu, Jianyu Wang, Chengyu Duan, Tong Wang, Yanbo Zhou
Summary: A bifunctional cationic cyclodextrin material (GD-DTAC) was designed for environmentally friendly water cleaning and recycling technologies, with adsorption and bactericidal function. The material showed great potential in removing pollutants from wastewater and suppressing micro-pollutants, with the ability to regulate surface positive charge and wettability through the introduction of rich quaternary ammonium groups by DTAC.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Agriculture, Dairy & Animal Science
Zhu Qiao, Jiaxin Chen, Qiaqia Zhou, Xin Wang, Yuanyuan Shan, Yanglei Yi, Bianfang Liu, Yuan Zhou, Xin Lu
Summary: Bacteriocin BM173 was successfully expressed and purified, showing broad-spectrum antibacterial activity, high thermal and pH stability, as well as efficacy in disrupting cell membrane integrity and inhibiting biofilm formation. These findings suggest that BM173 has promising potential as a preservative in the dairy industry.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Polymer Science
Shusu Ren, Xiang Xu, Jiyuan Sun, Haitao Zhao, Weiwei He, Lifen Zhang, Zhenping Cheng
Summary: This study synthesized a series of cationic porphyrin-based star-shaped copolymers using photo-controlled bromine-iodine transformation reversible-deactivation radical polymerization. The effects of alkyl chain length, degree of polymerization, and hydrophilic-hydrophobic balance on the antibacterial activity of the polymers were investigated. The resulting copolymer Zn@P6 showed excellent photodynamic inhibition activity against both S. aureus and E. coli, with low cytotoxicity and promising biological application prospects.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Romana Vrzonova, Alzbeta Cizova, Lucia Rackova, Jana Mecarova, Sandra Bielikova, Slavomir Bystricky
Summary: The rise of multidrug-resistant bacteria has increased the demand for new biocompatible and biodegradable antibacterial compounds. Cationic polysaccharides, such as derivatives of commercial dextrans, show promising antimicrobial properties. The study found that derivatives with higher degree of substitution and varying molar masses had better antimicrobial efficiency. However, as the molar mass increased, the biocompatibility of the cationic dextran decreased, showing hemagglutination and toxicity to human cells. The derivatives of 76 kDa dextran with higher degree of substitution were identified as the best antimicrobial agents for further clinical testing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Brenda Cardoso, Fernanda Esposito, Herrison Fontana, Bruna Fuga, Quezia Moura, Elder Sano, Maria I. Z. Sato, Carlos J. Brandao, Flavio A. Oliveira, Carlos E. Levy, Nilton Lincopan
Summary: The convergence of resistance and virulence in Klebsiella pneumoniae is a global public health issue. A multidrug-resistant CTX-M-15-producing strain (TIES-4900) was isolated from a highly impacted urban river in Brazil. This strain exhibited a broad resistome and virulome, and showed significant virulence in the Galleria mellonella infection model.
Article
Microbiology
Fabio P. Sellera, Miriam R. Fernandes, Bruna Fuga, Herrison Fontana, Felipe Vasquez-Ponce, Daphne W. Goldberg, Daniel F. Monte, Larissa Rodrigues, Adriana R. Cardenas-Arias, Ralf Lopes, Brenda Cardoso, Daniela G. C. Costa, Fernanda Esposito, Nilton Lincopan
Summary: This study in Brazil assessed critical priority pathogens circulating at the human-animal-environment interface and identified multidrug-resistant Citrobacter portucalensis in green sea turtles. The genomic analysis revealed the dissemination of different arrays of clinically relevant genes, making C. portucalensis a global priority pathogen.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Caroline Rodrigues da Silva, Marlon do Valle Barroso, Katia Suemi Gozi, Herrison Fontana, Mara Correa Lelles Nogueira, Nilton Lincopan, Tiago Casella
Summary: The study reveals the presence of a variety of antimicrobial resistance genes in Escherichia coli strains circulating in the Brazilian poultry sector, which pose a potential threat to human and animal health. Additionally, the strains show high genomic diversity.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Caetano P. Sabino, Martha S. Ribeiro, Mark Wainwright, Carolina Dos Anjos, Fabio P. Sellera, Milena Dropa, Nathalia B. Nunes, Guilherme T. P. Brancini, Gilberto U. L. Braga, Victor E. Arana-Chavez, Raul O. Freitas, Nilton Lincopan, Mauricio S. Baptista
Summary: The uncontrolled spread of multidrug-resistant pathogens is a major global health threat. Antimicrobial photodynamic therapy (aPDT) offers a promising approach to treating localized infections without being limited by drug resistance. In this study, various techniques were used to investigate the biochemical mechanisms of aPDT. The results suggest that protein degradation correlates with microbial inactivation kinetics, providing important insights for the development of optimized photosensitizing drugs and combination therapies with antimicrobial chemotherapy.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Environmental Sciences
Andre Becker Simoes Saidenberg, Leticia Soares Franco, Jessica Nacarato Reple, Yaovi Mahuton Gildas Hounmanou, Monique Ribeiro Tiba Casas, Brenda Cardoso, Fernanda Esposito, Nilton Lincopan, Anders Dalsgaard, Marc Stegger, Terezinha Knobl
Summary: Salmonella serovars Heidelberg and Minnesota with resistance to third-generation cephalosporins and fluoroquinolones are frequently found in Brazilian poultry. Genomic analysis revealed the presence of virulent and multidrug-resistant characteristics in these isolates, with AmpC beta-lactamase (bla(CMY-2)) predominance in Salmonella Minnesota (SM) and some Salmonella Heidelberg (SH) on IncC plasmid replicons. The study also identified close genetic similarity between the Brazilian isolates and poultry/food isolates from Europe, as well as human isolates from European countries importing Brazilian poultry meat. Overall, this research highlights the ongoing acquisition and dissemination of antimicrobial resistance in SH and Minnesota, raising concerns for importing countries and emphasizing the need to control AMR in major poultry-exporting countries like Brazil.
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2023)
Article
Environmental Sciences
Danny Fuentes-Castillo, Daniela Castro-Tardon, Fernanda Esposito, Ingrith Neves, Larissa Rodrigues, Herrison Fontana, Bruna Fuga, Jose L. Catao-Dias, Nilton Lincopan
Summary: A study found ESBL-producing Escherichia coli in wild birds from a remote island in Chilean Patagonia, indicating the potential transhemispheric movement of international clones of critical priority ESBL-producing pathogens. These strains carried a wide range of resistance and virulence genes associated with human and animal infections.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Editorial Material
Immunology
Gerson Nakazato, Renata Katsuko Takayama Kobayashi, Marcia Regina Eches Perugini, Nilton Lincopan, Eliana Carolina Vespero
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Carolina dos Anjos, Leon G. Leanse, Martha S. Ribeiro, Fabio P. Sellera, Milena Dropa, Victor E. Arana-Chavez, Nilton Lincopan, Mauricio S. Baptista, Fabio C. Pogliani, Tianhong Dai, Caetano P. Sabino
Summary: Antimicrobial drug development is under scrutiny due to the worldwide antibiotic crisis. Antimicrobial blue light (aBL) has been recognized as a potential therapy for infections, but the specific targets for bacterial killing by aBL are still poorly understood and may vary depending on the bacterial species.
MICROBIOLOGY SPECTRUM
(2023)
Article
Public, Environmental & Occupational Health
Elder Sano, Fernanda Esposito, Herrison Fontana, Bruna Fuga, Adriana Cardenas-Arias, Quezia Moura, Brenda Cardoso, Gladyston C. V. Costa, Tatiana C. M. Bosqueiro, Juliana A. Sinhorini, Eduardo de Masi, Caroline C. Aires, Nilton Lincopan
Summary: WHO priority pathogens have spread to urban and wild animals, including urban pigeons and rodents, which can serve as reservoirs for severe diseases. Genomic analysis of ceftriaxone and ciprofloxacin resistant Escherichia coli strains isolated from pigeons and rats revealed the presence of international clones carrying a broad range of resistance genes. These findings confirm the dissemination of clinically relevant pathogens and their resistance genes in urban animals, posing a critical issue in One Health perspective.
Article
Public, Environmental & Occupational Health
Gislaine Dalazen, Danny Fuentes-Castillo, Luiz G. Pedroso, Herrison Fontana, Elder Sano, Brenda Cardoso, Fernanda Esposito, Quezia Moura, Bianca S. Matinata, Luiz F. Silveira, Mashkoor Mohsin, Eliana R. Matushima, Nilton Lincopan
Summary: Wild birds in South America have been found to carry ESBL-producing bacteria, specifically E.coli ST602, which possess a wide range of antibiotic resistance genes and virulence factors. These findings suggest that wild birds may serve as a reservoir for critical pathogens, highlighting the importance of monitoring antibiotic resistance in wildlife populations.
Article
Public, Environmental & Occupational Health
Fernanda Esposito, Brenda Cardoso, Fabio P. Sellera, Elder Sano, Danny Fuentes-Castillo, Herrison Fontana, Bruna Fuga, Quezia Moura, Maria I. Z. Sato, Carlos J. Brandao, Nilton Lincopan
Summary: The spread of carbapenemase-producing Klebsiella pneumoniae beyond hospital settings is a global critical issue. The convergence of virulence and resistance in healthcare-associated lineages of K. pneumoniae leads to unfavorable clinical outcomes. Aquatic environments can become potential sources of international clones of K. pneumoniae displaying carbapenem resistance and hypervirulent behaviors.
Article
Microbiology
Bruna Fuga, Fabio P. Sellera, Louise Cerdeira, Fernanda Esposito, Brenda Cardoso, Herrison Fontana, Quezia Moura, Adriana Cardenas-Arias, Elder Sano, Rosineide M. Ribas, Albalucia C. Carvalho, Maria Cristina B. Tognim, Marcia Maria C. de Morais, Ana Judith P. G. Quaresma, Angela Patricia Santana, Joice N. Reis, Marcelo Pilonetto, Eliana Carolina Vespero, Raquel R. Bonelli, Aloysio M. F. Cerqueira, Thais C. M. Sincero, Nilton Lincopan
Summary: The rapid spread of carbapenem and third-generation cephalosporin-resistant pathogens in Brazil poses a serious threat to global health, emphasizing the importance of integrated whole-genome sequencing surveillance data from human, animal, and environmental sources in tracking transmission routes and developing effective prevention and control strategies.
MICROBIOLOGY SPECTRUM
(2022)
Article
Mycology
Marco Vianello, Daniel F. F. de Jesus, Jorge M. Sampaio, Guilherme M. de Oliveira, Nilton Lincopan, Kelly Ishida
Summary: This article reports a case of bacterial and fungal infections during hospitalization of a COVID-19 patient. The bacterial infection was successfully treated with broad-spectrum antibiotics, but the fungal infection in the urinary tract persisted and eventually led to the patient's death. With the increasing number of immunocompromised individuals due to COVID-19, invasive fungal infections have become more common, highlighting the importance of proper surveillance and diagnosis of fungal infections.
REVISTA IBEROAMERICANA DE MICOLOGIA
(2022)
