Article
Engineering, Biomedical
Dongsheng Yu, Yazhou Wang, Jifeng Chen, Shuang Liu, Shaohui Deng, Chengbo Liu, Iain McCulloch, Wan Yue, Du Cheng
Summary: Semiconducting polymer (SP) has been optimized through engineering the backbone and alkyl side-chains for co-delivery with pH-sensitive prodrug copolymer, leading to a synergistic photothermal therapy and chemotherapy combination. The SP-encapsulated nanoparticles exhibit high photothermal conversion efficiency and rapid DOX release under acidic conditions, resulting in efficient tumor treatment and potential synergistic effects in vivo.
ACTA BIOMATERIALIA
(2022)
Article
Biotechnology & Applied Microbiology
Xiangwei Lin, Zhourui Xu, Jiangao Li, Hongji Shi, Zhenyu Fu, Yuqing Chen, Wenguang Zhang, Yibin Zhang, Haoming Lin, Gaixia Xu, Xin Chen, Siping Chen, Mian Chen
Summary: This study developed a new type of polymer dots for the visualization of photothermal therapy and temperature measurement using photoacoustic detection. The results showed that these polymer dots had high photothermal conversion efficiency and accurate temperature measurement capabilities.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Maryam Deinavizadeh, Alireza Kiasat, Nasrin Hooshmand, Mohammad Shafiei, Mohammad Sabaeian, Roya Mirzajani, Seyed Mohammadsaleh Zahraei, Hagar Labouta, Mostafa A. El-Sayed
Summary: A novel biocompatible nanocomposite, consisting of gold nanorods coated with rod-like mesoporous silica particles, has been designed for synergistic thermal and chemotherapeutic delivery in eradicating cancer cells. The nanocomposite demonstrated high potential therapeutic efficacy in ablation of lung cancer cells through a combination of photothermal and chemotherapy treatments.
Article
Engineering, Environmental
Daifeng Li, Chi Zhang, Xiaoyan Tai, Denghui Xu, Jianzhong Xu, Pengfei Sun, Quli Fan, Zhen Cheng, Yi Zhang
Summary: This study developed a novel nanoplatform, P2NPs, with strong photothermal therapy and dual-modal optical tracking capabilities. In vitro and in vivo experiments demonstrated the potential of this platform in the treatment of osteosarcoma.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Meng Li, Xintong Bian, Xu Chen, Ningke Fan, Hongmi Zou, Yixi Bao, Yu Zhou
Summary: Retinoblastoma is a malignant intraocular neoplasm that commonly leads to delayed diagnosis and treatment. Researchers have developed a novel nanoplatform that allows both imaging and targeted treatment. This nanoplatform has excellent dual-modal imaging and photothermal therapy capabilities, and holds significant value in diagnosing and treating retinoblastoma.
Article
Chemistry, Multidisciplinary
Xingyu Wang, Changwei Li, Junchao Qian, Xiaotong Lv, Hong Li, Jinglu Zou, Jiahui Zhang, Xiangfu Meng, Hongji Liu, Yong Qian, Wenchu Lin, Hui Wang
Summary: This paper reports a new hollow magnetite nanocluster (HMNC) responsive to the second near-infrared (NIR-II) window for targeted and imaging-guided cancer therapy. The HMNC serves as a contrast agent for tumor-targeted magnetic resonance imaging and can trigger drug release and hydroxyl radical formation for chemotherapy and chemodynamic therapy. It also converts NIR-II light into local heat for photothermal therapy, showing great potential as a versatile nanoplatform for trimodal cancer therapy.
Review
Chemistry, Multidisciplinary
Chao Yin, Xiaozhen Li, Yi Wang, Yuying Liang, Shan Zhou, Pengchao Zhao, Chun-Sing Lee, Quli Fan, Wei Huang
Summary: Organic semiconducting macromolecular dyes (OSMDs) are emerging as alternative candidates for NIR-II photoacoustic imaging (PAI) and photothermal therapy (PTT) due to their reliable biocompatibility, durable photostability, and ideal photothermal conversion capability. Their applications in the NIR-II optical window include tumor imaging, stem cell tracking, vasculature imaging, and tumor ablation.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Mao Ying-Yan, Li Meng, Wang Jin-Da, Wang Kai-Jie, Zhang Jing-Shang, Chen Shu-Ying, Liu Xu, Liang Qing-Feng, Gao Fei, Wan Xiu-Hua
Summary: Posterior capsule opacification (PCO) is a common complication after cataract surgery, and pharmacological prophylaxis has been proven effective but lacks suitable clinical options. A novel concept of NIR dual-triggered drug release from black phosphorus-based implantable intraocular lens (IOL) for controlled drug release and chemo-photothermal combination therapy of PCO was proposed. The integrated IOL with black phosphorus-loaded doxorubicin showed good transmittance, mechanical properties, NIR dual-triggered drug release behaviors, and excellent photothermal efficacy, demonstrating promising results in inhibiting PCO in in vivo studies.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemical Research Methods
Zhifang Li, Cheng Zhang, Xuan Zhang, Jian Sui, Long Jin, Lisheng Lin, Qinrui Fu, Hongxin Lin, Jibin Song
Summary: Photoacoustic imaging (PAI) is a promising technique for the diagnosis and treatment of diseases. In the second near-infrared (NIR-II) window, PAI can effectively overcome the interference of tissue fluorescence and obtain high resolution images. NIR-II PA contrast agents have been developed to improve the performance of PAI in disease diagnosis and treatment. The applications of NIR-II PA contrast agents in medical imaging, such as cancer imaging and inflammation detection, are discussed.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Physical
Jun Yang, Zhen Sun, Qingqing Dou, Shuhan Hui, Peng Zhang, Rui Liu, Di Wang, Shan Jiang
Summary: A multiplex NIR light-responsive hydrogel platform (SA/DOX@hydrogel) is created for controlled synergetic chemotherapy and photothermal cancer therapy. The platform incorporates Ag nanoparticles doped SnS2 nanoflowers (SA) for photothermal effect and doxorubicin (DOX) for chemotherapy. The heat generated by NIR irradiation induces the release of DOX, while SA converts NIR light into thermal energy. In vitro and in vivo studies demonstrate the high efficacy of the SA/DOX@hydrogel system in killing cancer cells and suppressing tumor growth, making it a promising approach for cancer treatment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Nanoscience & Nanotechnology
Xing-Qun Pu, Xiao-Jie Ju, Lei Zhang, Quan-Wei Cai, Yu-Qiong Liu, Han-Yu Peng, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: A novel class of multifunctional responsive nanoparticles was designed and fabricated as drug nanocarriers for synergetic chemo-photothermal therapy of tumors. These nanoparticles demonstrated good biocompatibility and outstanding photothermal conversion efficiency, with controlled drug release under low pH and high temperature conditions. Experimental results showed that the nanoparticles were phagocytosed by tumor cells and released drugs in acidic environments, with higher efficacy in combined chemo and photothermal therapy compared to individual treatments.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Xiaowei Wang, Yufen Li, Ji Li, Yaxuan Gu, Lihong Sang, Dongkai Wang
Summary: The combination of multiple therapies can significantly improve the treatment efficiency of malignant tumors, and the combination of AS-IV and ICG enhances the anti-tumor effect. Liposomes co-loaded with AS-IV and ICG for chemo-photothermal therapy of breast cancer show promising results in vitro and in vivo, providing a safe and efficient strategy for synergistic combination therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Patihul Husni, Yuseon Shin, Hyewon Jeon, Eun Seong Lee, Yu Seok Youn, Chi-Duen Poon, Chaemin Lim, Kyung Taek Oh
Summary: This study developed a new pH-sensitive chemo-photothermal combination agent and evaluated its anticancer efficacy in vitro and in vivo. The agent showed repeated exposure to near-infrared laser and demonstrated excellent antitumor activities in targeting acidic tumors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Gabriela Guedes, Shiqi Wang, Flavia Fontana, Patricia Figueiredo, Jere Linden, Alexandra Correia, Ricardo J. B. Pinto, Sami Hietala, Filipa L. Sousa, Helder A. Santos
Summary: Polyoxometalates, specifically the {Mo-154} wheel-shaped cluster, show promise as photothermal agents, but toxicity limits systemic administration. This study introduces an injectable and self-healing hydrogel incorporating {Mo-154} and doxorubicin for synergistic photothermal and chemotherapy applications. The hydrogel's dual crosslinking allows for self-healing after injection, while a stimuli-responsive release system enables precise delivery of chemotherapeutic drugs triggered by dual near infrared radiation and pH changes for effective cancer tumor ablation with no systemic toxicity.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xiao Chu, Liufang Zhang, Yiling Li, Yue He, Yu Zhang, Chang Du
Summary: This study develops a nanocatalytic platform that enhances the efficacy of chemodynamic therapy (CDT) for osteosarcoma treatment. The platform depletes excess glutathione (GSH) and triggers the generation of highly toxic hydroxyl radicals by converting endogenous hydrogen peroxide. Both in vitro and in vivo experiments demonstrate the significantly improved anti-osteosarcoma effect of the synergistic chemodynamic/photothermal/chemo-therapy.
Article
Nanoscience & Nanotechnology
Cui-e Zhao, Jia Chen, Yuanzhao Ding, Victor Bochuan Wang, Biqing Bao, Staffan Kjelleberg, Bin Cao, Say Chye Joachim Loo, Lianhui Wang, Wei Huang, Qichun Zhang
ACS APPLIED MATERIALS & INTERFACES
(2015)
Article
Chemistry, Multidisciplinary
Dongliang Yang, Shuwei Zhang, Yanling Hu, Jia Chen, Biqing Bao, Lihui Yuwen, Lixing Weng, Yixiang Cheng, Lianhui Wang
Article
Chemistry, Multidisciplinary
Biqing Bao, Jin Zhu, Lina Gong, Jia Chen, Yanrui Pan, Lianhui Wang
Article
Chemistry, Analytical
Biqing Bao, Yanrui Pan, Bingbing Gu, Jia Chen, Yu Xu, Peng Su, Yunfei Liu, Li Tong, Lianhui Wang
Article
Nanoscience & Nanotechnology
Biqing Bao, Mingfeng Ma, Jia Chen, Lihui Yuwen, Lixing Weng, Quli Fan, Wei Huang, Lianhui Wang
ACS APPLIED MATERIALS & INTERFACES
(2014)
Article
Nanoscience & Nanotechnology
Jia Chen, Jingyang Shan, Yu Xu, Peng Su, Li Tong, Lihui Yuwen, Lixing Weng, Biqing Bao, Lianhui Wang
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Chemistry, Analytical
Biqing Bao, Peng Su, Jin Zhu, Jia Chen, Yu Xu, Bingbing Gu, Yunfei Liu, Lianhui Wang
Article
Biophysics
Biqing Bao, Zhenyuan Yang, Yunfei Liu, Yu Xu, Bingbing Gu, Jia Chen, Peng Su, Li Tong, Lianhui Wang
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Chemistry, Physical
Kennedy S. Chen, Lin Qi, Jia Chen, Ruibing Wang, Hua-Zhong Yu
Summary: In this study, alkyne-functionalized CB[7] was successfully immobilized on gold surfaces. The resulting CB[7]-functionalized SAMs showed high stability and uniformity. The study revealed that surface-bound CB[7] exhibits strong host-guest binding towards both cationic and neutral ferrocene derivatives, as well as comparable binding stability towards anionic ferrocene derivatives.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Nanoscience & Nanotechnology
Jia Chen, Qiaoxian Huang, Qingfu Wang, Yuanfu Ding, Siyu Lu, Lian-Hui Wang, Shengke Li, Ruibing Wang
Summary: This study presents a novel bioluminescent probe, based on SLA NPs, for deep-tissue inflammation imaging, offering enhanced imaging performance and biocompatibility.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jia Chen, Shengke Li, Zeyu Wang, Yating Pan, Jianwen Wei, Siyu Lu, Qing-Wen Zhang, Lian-Hui Wang, Ruibing Wang
Summary: This study presents an AIE photosensitizer functionalized CB[7], AIECB[7], which can self-assemble into nanoaggregates and fine-tune fluorescence and singlet oxygen generation. Additionally, by loading oxaliplatin and hypoxia-activatable prodrug banoxantrone (AQ4N) into AIECB[7] nanoaggregates, synergistic antitumor effects were demonstrated, highlighting the versatile theranostic applications of this supramolecular system.
Article
Materials Science, Biomaterials
Jia Chen, Yunxiao Cui, Kewei Song, Tianqi Liu, Luyao Zhou, Biqing Bao, Ruibing Wang, Lianhui Wang
Summary: The study designed and synthesized a novel photosensitizer based on boron dipyrromethene (BODIPY) for simultaneous photodynamic therapy (PDT) and photothermal therapy (PTT), with a synergistic effect to enhance the antitumor efficiency. The hybrid photosensitizer showed improved phototherapeutic outcome compared to its counterpart, offering guidance for the development of balanced NIR nanoagents for cancer therapeutic efficacy in the future.
BIOMATERIALS SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Jia Chen, Yu Xu, Yu Gao, Dongliang Yang, Fei Wang, Lei Zhang, Biqing Bao, Lianhui Wang
ACS APPLIED MATERIALS & INTERFACES
(2018)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
