Therapeutic potential of targeting the Wnt/β-catenin pathway in the treatment of pancreatic cancer

Anti-tumoral effects of low molecular weight heparins: A focus on the treatment of esophageal cancer

(2018) Seyed Alireza Javadinia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Therapeutic Potential of Targeting Wnt/β-Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress

(2017) Afsane Bahrami et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MUC1 induces acquired chemoresistance by upregulating ABCB1 in EGFR-dependent manner

(2017) Wei Jin et al.   Cell Death & Disease

Global temporal patterns of pancreatic cancer and association with socioeconomic development

(2017) Martin C. S. Wong et al.   Scientific Reports

Phase 1b study of WNT inhibitor vantictumab (VAN, human monoclonal antibody) with nab-paclitaxel (Nab-P) and gemcitabine (G) in patients (pts) with previously untreated stage IV pancreatic cancer (PC)

(2016) W. Messersmith et al.   ANNALS OF ONCOLOGY

Phase 1b study of WNT inhibitor ipafricept (IPA, decoy receptor for WNT ligands) with nab-paclitaxel (Nab-P) and gemcitabine (G) in patients (pts) with previously untreated stage IV pancreatic cancer (PC)

(2016) C. Weekes et al.   ANNALS OF ONCOLOGY

Abstract 2276: Sorafenib/Refametinib potently inhibits Wnt/β-catenin in vitro and patient-derived xenograft models of human hepatocellular carcinoma

(2016) Huynh T. Hung et al.   CANCER RESEARCH

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Phase I/II Study of Refametinib (BAY 86-9766) in Combination with Gemcitabine in Advanced Pancreatic cancer

(2016) Jean-Luc Van Laethem et al.   Targeted Oncology

Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61

(2016) Makoto Sano et al.   NEOPLASIA

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

(2015) Daniel V.T. Catenacci et al.   JOURNAL OF CLINICAL ONCOLOGY

Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer

(2015) M. D. Arensman et al.   MOLECULAR CANCER RESEARCH

Familial Adenomatous Polyposis and Pancreatic Cancer

(2015) Driffa Moussata et al.   PANCREAS

New insights into pancreatic cancer stem cells

(2015) Chinthalapally V Rao   World Journal of Stem Cells

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

(2014) Eliana Amato et al.   JOURNAL OF PATHOLOGY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Biliary tree stem cells, precursors to pancreatic committed progenitors: Evidence for possible life-long pancreatic organogenesis

(2013) Yunfang Wang et al.   STEM CELLS

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma

(2013) Nobumasa Mizuno et al.   Frontiers in Physiology

Inherited Pancreatic Cancer Syndromes

(2012) Sheila Solomon et al.   CANCER JOURNAL

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

(2012) Meredith A. Collins et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic cancer stem cells: regulatory networks in the tumor microenvironment and targeted therapy

(2012) Sonshin Takao et al.   Journal of Hepato-Biliary-Pancreatic Sciences

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2

(2011) Bo Gao et al.   DEVELOPMENTAL CELL

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

(2011) John Burn et al.   LANCET

Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis

(2011) Inamul Haque et al.   Molecular Cancer

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

(2011) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization

(2010) C. Metcalfe et al.   JOURNAL OF CELL SCIENCE

Phase II Trial of Gemcitabine, Irinotecan, and Celecoxib in Patients With Advanced Pancreatic Cancer

(2010) Allan Lipton et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression

(2008) Elizabeth Vincan et al.   CLINICAL & EXPERIMENTAL METASTASIS

A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95

(2008) Takeyuki Sugiura et al.   EXPERIMENTAL CELL RESEARCH

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

(2008) Viljar Jaks et al.   NATURE GENETICS