γ-secretase inhibitor DAPT mitigates cisplatin-induced acute kidney injury by suppressing Notch1 signaling

Dynamic Ligand Discrimination in the Notch Signaling Pathway

(2018) Nagarajan Nandagopal et al.   CELL

Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding

(2018) Hitesh Soni et al.   RENAL FAILURE

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Renal Outcomes after Cisplatin Treatment

(2016) S. Latcha et al.   Clinical Journal of the American Society of Nephrology

Sequential combination therapy of ovarian cancer with cisplatin and γ-secretase inhibitor MK-0752

(2016) XiuXiu Chen et al.   GYNECOLOGIC ONCOLOGY

Molecular mechanisms of cisplatin resistance in cervical cancer

(2016) Xueqiong Zhu et al.   Drug Design Development and Therapy

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin-Based Chemoradiotherapy Regimen for Head and Neck Carcinomas

(2016) Jantien Hoek et al.   Cancers

TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways

(2016) Hitesh Soni et al.   Scientific Reports

Incidence of Cisplatin-Induced Nephrotoxicity and Associated Factors among Cancer Patients in Indonesia

(2015) Yenny Prasaja et al.   Asian Pacific Journal of Cancer Prevention

Notch signaling: An emerging therapeutic target for cancer treatment

(2015) Xun Yuan et al.   CANCER LETTERS

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo

(2015) Kristina Preuße et al.   PLoS Genetics

Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy

(2014) Juntao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pretreatment with the γ-secretase inhibitor DAPT sensitizes drug-resistant ovarian cancer cells to cisplatin by downregulation of Notch signaling

(2014) MINGYI WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells

(2014) K Fujiki et al.   Cell Death & Disease

The Notch signaling pathway as a mediator of tumor survival

(2013) K. M. Capaccione et al.   CARCINOGENESIS

Survivin Mediates Renal Proximal Tubule Recovery from AKI

(2013) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glomerulopathy in the KK.Cg-Ay/J Mouse Reflects the Pathology of Diabetic Nephropathy

(2013) Stephen P. O'Brien et al.   Journal of Diabetes Research

Cisplatin Selects for Multidrug-Resistant CD133+ Cells in Lung Adenocarcinoma by Activating Notch Signaling

(2012) Y.-P. Liu et al.   CANCER RESEARCH

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

(2012) S. M. McAuliffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch Signaling

(2012) R. Kopan   Cold Spring Harbor Perspectives in Biology

Regulation of Notch1 signaling by the APP intracellular domain facilitates degradation of the Notch1 intracellular domain and RBP-Jk

(2011) M.-Y. Kim et al.   JOURNAL OF CELL SCIENCE

Inhibition of NOTCH3 signalling significantly enhances sensitivity to cisplatin in EBV-associated nasopharyngeal carcinoma

(2011) Cheuk-Him Man et al.   JOURNAL OF PATHOLOGY

Notch in the kidney: development and disease

(2011) Yasemin Sirin et al.   JOURNAL OF PATHOLOGY

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Notch2/Hes-1 Pathway Plays an Important Role in Renal Ischemia and Reperfusion Injury-Associated Inflammation and Apoptosis and the γ-Secretase Inhibitor DAPT has a Nephroprotective Effect

(2011) RenFa Huang et al.   RENAL FAILURE

γ-secretase inhibition combined with cisplatin enhances apoptosis of nasopharyngeal carcinoma cells

(2011) JUN-XU ZHOU et al.   Experimental and Therapeutic Medicine

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

The story of Notch and chronic kidney disease

(2010) Shuchita Sharma et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Review of the Basic and Clinical Pharmacology of Sulfobutylether-β-Cydodextrin (SBECD)

(2010) David R. Luke et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Estimation of glomerular filtration rate in dogs by plasma clearance of gadolinium diethylenetriamine pentaacetic acid as measured by use of an ELISA

(2009) Benjamin G. Nolan et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells

(2008) Tamara Aleksic et al.   Cell Communication and Signaling

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL

Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury

(2008) T. Kobayashi et al.   KIDNEY INTERNATIONAL

Cyclodextrins

(2008) Valentino J. Stella et al.   TOXICOLOGIC PATHOLOGY