Article
Biochemistry & Molecular Biology
Qianqian Yang, Lulu Wang, Yuehong Liang, Qingyu He, Qi Sun, Jing Luo, Hongdi Cao, Yi Fang, Yang Zhou, Junwei Yang, Ping Wen, Lei Jiang
Summary: Mitochondrial dysfunction is involved in podocyte injury and proteinuria. UCP2 plays a role in regulating mitochondrial dynamics in podocytes, and its deficiency promotes proteinuria.
Article
Biochemistry & Molecular Biology
Qianqian Yang, Lulu Wang, Yuehong Liang, Qingyu He, Qi Sun, Jing Luo, Hongdi Cao, Yi Fang, Yang Zhou, Junwei Yang, Ping Wen, Lei Jiang
Summary: Mitochondrial dysfunction, regulated by UCP2, plays a crucial role in the development of podocyte injury and proteinuria.
Review
Cell Biology
Robert Gilkerson, Patrick De la Torre, Shaynah St. Vallier
Summary: Mammalian mitochondria play a crucial role in cellular stress response and development outcomes, responding to stimuli and stresses through structural dynamics. Fusion and fission of mitochondria, regulated by OPA1, are essential for maintaining organelle structure and function. The proteolytic mechanism involving OMA1 provides sensitive regulation of mitochondrial structure/function and is implicated in apoptotic pathways and cellular stress response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tianshu Hao, Jianglong Yu, Zhida Wu, Jie Jiang, Longlong Gong, Bingjun Wang, Hanze Guo, Huabin Zhao, Bin Lu, Simone Engelender, He He, Zhiyin Song
Summary: Mitochondria are key organelles for oxygen sensing, while lysosomes contain hydrolytic enzymes for degradation. This study shows that under hypoxia, mitochondria engulf and degrade lysosomes, leading to the formation of large mitochondria and a process called mitochondrial self-digestion. These findings uncover a mode of communication between mitochondria and lysosomes, as well as a novel pathway for mitochondrial degradation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Wenbo Yang, Xiaoli Li, Liujie He, Shuyang Zhu, Shicong Lai, Xiaopeng Zhang, Zixiong Huang, Biyue Yu, Chunping Cui, Qiang Wang
Summary: This study found that empagliflozin can prevent renal ischemia-reperfusion injury by inhibiting mitochondrial division and reducing inflammation. Animal experiments and cell experiments confirmed the protective effects of empagliflozin and its regulation of the AMPK-OPA1 pathway.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Cell Biology
Sofia Ahola, Pablo Rivera Mejias, Steffen Hermans, Srikanth Chandragiri, Patrick Giavalisco, Hendrik Nolte, Thomas Langer
Summary: This study reveals that deficiencies in the oxidative phosphorylation system can lead to cardiomyopathy and heart failure in mitochondrial disease. The loss of the assembly factor Cox10 causes mitochondrial cardiomyopathy in mice, resulting in abnormalities in mitochondrial morphology and lysosomal function. The activation of the mitochondrial peptidase Oma1 triggers the integrated stress response, which has a protective role in mitochondrial cardiomyopathy. Inhibition of the integrated stress response impairs cardiac glutathione metabolism and increases lipid peroxidation, ultimately leading to ferroptosis.
Review
Medicine, Research & Experimental
Jie Huang, Lei Chen, Zi-meng Yao, Xiao-rong Sun, Xu-hui Tong, Shu-ying Dong
Summary: Stroke, particularly ischemic stroke, is a major cause of death and disability worldwide. Reperfusion, the restoration of blood supply, is crucial for treatment, but it can also worsen the injury through cerebral ischemia-reperfusion injury (CIRI). Mitochondrial dysfunction is a key characteristic of CIRI, and improving mitochondrial dynamics is considered a potential therapeutic approach to improve outcomes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Evelyn Fessler, Insung Y. Song, Nicholas P. Randolph, Yan Li, Christopher K. E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quiros, Carlos Lopez-Otin, Lucas T. Jae, Joanna Poulton, Derek P. Narendra
Summary: Mitochondrial stress triggers responses in both cellular mitochondria and nucleus. This study focuses on the impact of a mutation in the mitochondrial protein CHCHD10, which causes myopathy. The study finds that the mutated CHCHD10 aggregates in affected tissues, causing toxic stress on the inner mitochondrial membrane. The research also reveals the crucial role of the mitochondrial metalloendopeptidase OMA1 in coordinating stress responses and reshaping the mitochondrial network and proteome.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biology
Richard Miallot, Virginie Millet, Yann Groult, Angelika Modelska, Lydie Crescence, Sandrine Roulland, Sandrine Henri, Bernard Malissen, Nicolas Brouilly, Laurence Panicot-Dubois, Renaud Vincentelli, Gerlind Sulzenbacher, Pascal Finetti, Aurelie Dutour, Jean-Yves Blay, Francois Bertucci, Franck Galland, Philippe Naquet
Summary: Aggressive tumors often have dysfunctional mitochondria. OMA1 mediates fission of mitochondria in response to oxidative stress through cleavage of the fusion effector OPA1. In this study, mutation of cysteine 403 in OMA1 impaired mitochondrial responses to stress, resulting in reduced ATP production, resistance to apoptosis, and enhanced mitochondrial DNA release. Inactivation of OMA1 increased anti-tumor immunity and may enhance sarcoma immunogenicity.
LIFE SCIENCE ALLIANCE
(2023)
Article
Cell Biology
Pablo Rivera-Mejias, Alvaro Jesus Narbona-Perez, Lidwina Hasberg, Lara Kroczek, Amir Bahat, Steffen Lawo, Kat Folz-Donahue, Anna-Lena Schumacher, Sofia Ahola, Fiona Carola Mayer, Patrick Giavalisco, Hendrik Nolte, Sergio Lavandero, Thomas Langer
Summary: The flexibility of mitochondria metabolism is crucial for cell development, differentiation, and survival. The enzyme OMA1 is involved in regulating mitochondrial morphology and stress signaling, impacting tumorigenesis and cell survival in a cell- and tissue-specific manner. This study reveals that OMA1-dependent cell survival relies on metabolic cues. By conducting a metabolism-focused CRISPR screen and analyzing human gene expression data, it was found that OMA1 protects against DNA damage. The deficiency of nucleotides induced by chemotherapeutic agents leads to p53-dependent apoptosis in cells lacking OMA1. The protective effect of OMA1 is not dependent on its activation or its role in the processing of OPA1 and DELE1. OMA1-deficient cells exhibit reduced glycolysis and accumulate oxidative phosphorylation (OXPHOS) proteins following DNA damage. Inhibition of OXPHOS restores glycolysis and provides resistance against DNA damage. Thus, OMA1 plays a role in balancing cell death and survival through the control of glucose metabolism, shedding light on its involvement in cancerogenesis.
Article
Multidisciplinary Sciences
Martonio Ponte Viana, Roman M. Levytskyy, Ruchika Anand, Andreas S. Reichert, Oleh Khalimonchuk
Summary: Remodeling of mitochondrial ultrastructure is critical for organelle physiology and apoptosis. OMA1, in addition to its role in mitochondrial division, is also required for maintaining intermembrane connectivity by dynamically associating with MICOS. This OMA1-MICOS relay is crucial for optimal bioenergetic output and cell apoptosis. Loss of OMA1 affects these functions but can be alleviated by a MICOS-emulating intermembrane bridge, highlighting OMA1's essential role in mitochondrial physiology.
Article
Pharmacology & Pharmacy
Chayodom Maneechote, Hiranya Pintana, Sasiwan Kerdphoo, Sornram Janjek, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: An imbalance of brain mitochondrial dynamics, increases in brain inflammation and apoptosis, and increasing cognitive dysfunction, have been reported as being associated with prediabetes and myocardial ischemiareperfusion (IR) injury. The neuroprotective roles of Mdivi-1 and M1 when administered at different time points of myocardial IR injury in obese prediabetes have never been determined.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Heena Khan, Amarjot Kaur Grewal, Thakur Gurjeet Singh
Summary: Mitochondria play a vital role in cellular energy production and various cellular activities, and their dysfunction is associated with neurological diseases and brain injuries. This review highlights the importance of mitochondria as critical targets in ischemia-induced processes and cell viability loss. The focus on preventing ischemia-reperfusion damage often involves strategies aimed at improving mitochondrial function. The review also summarizes the mitochondrial pathways involved in disease progression and explores the potential therapies for cerebral injury-induced injuries by regulating miRNA and mitochondrial dynamics.
Article
Biochemistry & Molecular Biology
Kun Zhang, Tao Wang, Gui-Feng Sun, Jin-Xing Xiao, Li-Ping Jiang, Fang-Fang Tou, Xin-Hui Qu, Xiao-Jian Han
Summary: This study aimed to evaluate the protective effect of metformin against retinal ischemia/reperfusion (I/R) injury and its underlying mechanism. The results showed that metformin could alleviate I/R-induced retinal injury through AMPK-mediated mitochondrial fusion and decreased generation of mitochondrial ROS.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jingxia Du, Hongchao Li, Jingjing Song, Tingting Wang, Yibo Dong, An Zhan, Yan Li, Gaofeng Liang
Summary: This study confirms the protective effects of AMPK activation on myocardial ischemia/reperfusion injury by regulating mitochondrial dynamics.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Muhammad Saif Ur Rahman, Jiang Cao
WORLD JOURNAL OF GASTROENTEROLOGY
(2016)
Review
Biotechnology & Applied Microbiology
Muhammad Umar Ali, Muhammad Saif Ur Rahman, Jiang Cao, Ping Xi Yuan
Review
Biotechnology & Applied Microbiology
Muhammad Umar Ali, Muhammad Saif Ur Rahman, Jiang Cao, Ping Xi Yuan
Article
Biotechnology & Applied Microbiology
Xiaoxiao Du, Lingyan Wu, Muhammad Saif Ur Rahman, Xiaodong Teng, Lisong Teng, Jingjia Ye, Jiang Cao
Article
Materials Science, Ceramics
Muhammad Saif ur Rahman, Muhammad Asif Tahir, Saima Noreen, Muhammad Yasir, Muhammad Bilal Khan, Tahir Mahmood, Ali Bahadur, Muhammad Shoaib
CERAMICS INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Shifen Huang, Yiming Zhang, Chenhong Wang, Qinghua Xia, Muhammad Saif Ur Rahman, Hao Chen, Charles Han, Ying Liu, Shanshan Xu
Summary: Polymer blending is a promising method to improve the stability and performance of implant scaffolds. This study investigates the modification mechanism of polymer blending at the molecular chain level, providing theoretical references for material R&D processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jinliang Nan, Jiamin Li, Yinuo Lin, Muhammad Saif Ur Rahman, Zhengzheng Li, Lingjun Zhu
Summary: Store-operated Ca2+ entry (SOCE) machinery and mitochondria are crucial for cellular calcium homeostasis and play key roles in cardiac diseases. They interact reciprocally and are involved in processes such as cardiac hypertrophy, diabetic cardiomyopathy, and cardiac ischaemia-reperfusion injury.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Materials Science, Ceramics
Muhammad Asif Tahir, Muhammad Saif Ur Rahman, Farheen Nisha, Faisal Shahzad, Muhammad Tayyab Jawad, Ali Bahadur, Muhammad Afzal Qamar, Muhammad Shoaib
Summary: Strontium-doped mesoporous bioactive glass nanoparticles (Sr-MBG NPs) with a size of 50 +/- 5 nm were successfully prepared using the sol-gel method. The biocompatibility of these nanoparticles was confirmed, and loading them with 5-fluorouracil (5-Fu) resulted in substantial inhibitory effects on cancer cell viability.
CERAMICS INTERNATIONAL
(2022)
Review
Physics, Multidisciplinary
Muhammad Saif Ur Rahman, Jiaen Wu, Hao Chen, Chengmei Sun, Ying Liu, Shanshan Xu
Summary: Understanding the relationship between tumors and their microenvironment is crucial for better understanding tumor progression and metastasis. Biomaterials that mimic the extracellular matrix must provide mechanical cues that cells receive from their 3D environment. Pore size is an important but less studied factor related to tumor invasion and migration. Electrospinning is a reliable technique for controlling the pore size of biomaterials. A comprehensive interpretation of ECM pore size contributes to a better understanding of its interaction with tumor progression and can be used as a promising target for cancer treatment.
ADVANCES IN PHYSICS-X
(2023)
Review
Biotechnology & Applied Microbiology
Zhipeng Zeng, Yajing Yang, Junyong Deng, Muhammad Saif Ur Rahman, Chengmei Sun, Shanshan Xu
Summary: This paper reviews the combined application of physical stimulation and biomaterials in peripheral nerve injury (PNI) repair. The combination of physical stimulation therapy with nerve biomaterials can enhance the repair effect and provide broader application prospects for PNI repair.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Saif Ur Rahman, Muhammad Asif Tahir, Saima Noreen, Muhammad Yasir, Ijaz Ahmad, Muhammad Bilal Khan, Khawajah Waqar Ali, Muhammad Shoaib, Ali Bahadur, Shahid Lqbal