Detyrosinated microtubules spatially constrain lysosomes facilitating lysosome–autophagosome fusion

3D motion of vesicles along microtubules helps them to circumvent obstacles in cells

(2017) Ione Verdeny-Vilanova et al.   JOURNAL OF CELL SCIENCE

Differentiation between Oppositely Oriented Microtubules Controls Polarized Neuronal Transport

(2017) Roderick P. Tas et al.   NEURON

BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon

(2017) Ginny G. Farías et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

(2017) Chrystelle Aillaud et al.   SCIENCE

Vasohibins encode tubulin detyrosinating activity

(2017) Joppe Nieuwenhuis et al.   SCIENCE

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

(2016) Jeffrey J. Nirschl et al.   Cell Reports

BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks

(2016) Carlos M. Guardia et al.   Cell Reports

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations

(2015) Marvin Bentley et al.   JOURNAL OF CELL BIOLOGY

Inferring transient particle transport dynamics in live cells

(2015) Nilah Monnier et al.   NATURE METHODS

Microtubule detyrosination guides chromosomes during mitosis

(2015) M. Barisic et al.   SCIENCE

Post-translational modifications of tubulin: pathways to functional diversity of microtubules

(2015) Yuyu Song et al.   TRENDS IN CELL BIOLOGY

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

(2015) Albert Herms et al.   Nature Communications

Post-translational modifications of tubulin

(2014) Maria M. Magiera et al.   CURRENT BIOLOGY

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

Cross-Talk-Free Multi-Color STORM Imaging Using a Single Fluorophore

(2014) Johnny Tam et al.   PLoS One

A Microfluidic Platform for Correlative Live-Cell and Super-Resolution Microscopy

(2014) Johnny Tam et al.   PLoS One

The role of the cytoskeleton and molecular motors in endosomal dynamics

(2014) Elizabeth Granger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Microtubule-Binding Protein Ensconsin Is an Essential Cofactor of Kinesin-1

(2013) Kari Barlan et al.   CURRENT BIOLOGY

Correlative live-cell and superresolution microscopy reveals cargo transport dynamics at microtubule intersections

(2013) Štefan Bálint et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Acetylated microtubules are required for fusion of autophagosomes with lysosomes

(2010) Rui Xie et al.   BMC CELL BIOLOGY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

(2010) Camille Geeraert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER sliding dynamics and ER–mitochondrial contacts occur on acetylated microtubules

(2010) Jonathan R. Friedman et al.   JOURNAL OF CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Superresolution Imaging of Chemical Synapses in the Brain

(2010) Adish Dani et al.   NEURON

Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

(2009) Carla M. P. Cardoso et al.   PLoS One

Single Molecule Imaging Reveals Differences in Microtubule Track Selection Between Kinesin Motors

(2009) Dawen Cai et al.   PLOS BIOLOGY

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

(2008) S. Dunn et al.   JOURNAL OF CELL SCIENCE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Three-Dimensional Super-Resolution Imaging by Stochastic Optical Reconstruction Microscopy

(2008) B. Huang et al.   SCIENCE

Different Microtubule Motors Move Early and Late Endocytic Compartments

(2008) Sylvain Loubéry et al.   TRAFFIC

The Itinerary of Autophagosomes: From Peripheral Formation to Kiss-and-Run Fusion with Lysosomes

(2008) Luca Jahreiss et al.   TRAFFIC