Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action

Affimer proteins are versatile and renewable affinity reagents

(2017) Christian Tiede et al.   eLife

Fc-gamma receptors: Attractive targets for autoimmune drug discovery searching for intelligent therapeutic designs

(2016) Carlos J. Bosques et al.   AUTOIMMUNITY REVIEWS

Label-free electrochemical impedance biosensor to detect human interleukin-8 in serum with sub-pg/ml sensitivity

(2016) R. Sharma et al.   BIOSENSORS & BIOELECTRONICS

Systematic Targeting of Protein–Protein Interactions

(2016) Ashley E. Modell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies

(2015) Hannah F. Kyle et al.   Molecular BioSystems

Phage display selected magnetite interacting Adhirons for shape controlled nanoparticle synthesis

(2015) Andrea E. Rawlings et al.   Chemical Science

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

Kinase inhibitors: The next generation of therapies in the treatment of rheumatoid arthritis

(2014) Lindsey A. MacFarlane et al.   International Journal of Rheumatic Diseases

Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications

(2014) Christian Tiede et al.   PROTEIN ENGINEERING DESIGN & SELECTION

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Protein–protein interactions as druggable targets: recent technological advances

(2013) Alicia P Higueruelo et al.   CURRENT OPINION IN PHARMACOLOGY

Effects of Fostamatinib (R788), an Oral Spleen Tyrosine Kinase Inhibitor, on Health-related Quality of Life in Patients with Active Rheumatoid Arthritis: Analyses of Patient-reported Outcomes from a Randomized, Double-blind, Placebo-controlled Trial

(2013) M. E. Weinblatt et al.   JOURNAL OF RHEUMATOLOGY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Evolutionary History of Copy-Number-Variable Locus for the Low-Affinity Fcγ Receptor: Mutation Rate, Autoimmune Disease, and the Legacy of Helminth Infection

(2012) Lee R. Machado et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Confirmation of association ofFCGR3Bbut notFCGR3Acopy number with susceptibility to autoantibody positive rheumatoid arthritis

(2012) James I. Robinson et al.   HUMAN MUTATION

Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond

(2012) P. Mark Hogarth et al.   NATURE REVIEWS DRUG DISCOVERY

FcγRIIIa Expression on Monocytes in Rheumatoid Arthritis: Role in Immune-Complex Stimulated TNF Production and Non-Response to Methotrexate Therapy

(2012) Dawn L. Cooper et al.   PLoS One

Structural biology and drug discovery for protein–protein interactions

(2012) Harry Jubb et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

High throughput construction and small scale expression screening of multi-tag vectors in Escherichia coli

(2011) Louise E. Bird   METHODS

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

(2009) J. W. Friedberg et al.   BLOOD

TRITON: a graphical tool for ligand-binding protein engineering

(2008) Martin Prokop et al.   BIOINFORMATICS

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

(2008) J. Vlasak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Copy number ofFCGR3B,which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

(2008) Lisa C. Willcocks et al.   JOURNAL OF EXPERIMENTAL MEDICINE