Article
Biochemistry & Molecular Biology
Reiko Kageyama, Taisuke Ito, Shiho Hanai, Naomi Morishita, Shinsuke Nakazawa, Toshiharu Fujiyama, Tetsuya Honda, Yoshiki Tokura
Summary: This study aimed to compare the immunological properties of different types of AA patients and their associated AD patients, revealing that type 2 immunity may be involved in AA development in patients with extrinsic AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Jocelyn M. Carnicle, Aleksi J. Hendricks, Vivian Y. Shi
Summary: This case report describes a 42-year-old woman with severe atopic dermatitis treated with dupilumab developing a reactivation of alopecia areata. Alopecia improved after treatment with intramuscular triamcinolone, raising suspicion of a potential adverse effect of dupilumab in patients with AD.
Article
Allergy
Helen He, Robert Bissonnette, Jianni Wu, Aisleen Diaz, Etienne Saint-Cyr Proulx, Catherine Maari, Carolyn Jack, Maudeline Louis, Yeriel Estrada, James G. Krueger, Ning Zhang, Ana B. Pavel, Emma Guttman-Yassky
Summary: This study utilized RNA-seq analysis of tape strips from lesional and nonlesional skin of patients with moderate-to-severe AD and psoriasis, revealing distinct immune and barrier signatures in the two diseases. The findings suggest the potential utility of tape strips as a minimally invasive alternative to biopsies for detecting disease biomarkers. Differences in gene expression profiles between AD and psoriasis highlight the unique pathophysiological mechanisms of these two skin disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Jessica W. Hui-Beckman, Elena Goleva, Evgeny Berdyshev, Donald Y. M. Leung
Summary: Atopic dermatitis (AD) and food allergy (FA) are closely related and one-third of AD children develop concomitant FA. Epithelial barrier dysfunction is important in both diseases. Genetic factors such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms are associated with increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA as well as activating the type 2 immune response. Comprehensive multiomic studies have identified distinct atopic endotypes with unique characteristics, providing an opportunity for improved diagnosis and prevention of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Anna Waskiel-Burnat, Anna Niemczyk, Paulina Chmielinska, Marta Muszel, Michal Zaremba, Adriana Rakowska, Malgorzata Olszewska, Lidia Rudnicka
Summary: This study compares the levels of adipokines lipocalin-2 and visfatin, as well as metabolic markers, between patients with alopecia areata and healthy controls. The results show significantly higher levels of lipocalin-2, insulin, and other markers in patients with alopecia areata, and a positive correlation with the number of hair loss episodes and body mass index.
Article
Allergy
Alain Lefevre-Utile, Melissa Saichi, Peter Olah, Marc Delord, Bernhard Homey, Vassili Soumelis
Summary: The study identified 4 endotypes of AD and discovered key gene sets associated with specific biological pathways. There were significant differences in disease severity and S. aureus colonization between different clusters. These findings could potentially provide new insights into personalized treatment strategies.
Article
Allergy
Jocelyn M. Biagini, John W. Kroner, Asel Baatyrbek Kyzy, Alexandra Gonzales, Hua He, Mariana Stevens, Brittany Grashel, Daniel Spagna, Samuel Paul, Rahul Patel, Angelo Bucci, Michael G. Sherenian, Liza Bronner Murrison, Lisa J. Martin, Gurjit K. Khurana Hershey
Summary: This study investigates the atopic march in Black and White children and identifies distinct allergic trajectories in these populations. It reveals that Black children have a higher risk of asthma despite a more intact skin barrier and less sensitization, food allergy, and allergic rhinitis. Conversely, White children have a lower risk of asthma despite a more dysfunctional skin barrier and higher rates of sensitization, food allergy, and allergic rhinitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Yunqing Ren, Jipeng Liu, Wei Li, Huiwen Zheng, Huatuo Dai, Guiying Qiu, Dianhe Yu, Dianyi Yao, Xianyong Yin
Summary: This study reported causal relationships between circulating vitamin D levels and the risk of psoriasis, atopic dermatitis, and vitiligo.
Review
Biochemistry & Molecular Biology
Wei-Yu Chen, Shao-Chuan Chen, Shou-Yi Hsu, Yu-An Lin, Chun-Ming Shih, Chun-Yao Huang, Kuo-Hsien Wang, Ai-Wei Lee
Summary: Skin diseases have a significant impact on individuals and society, and there is a need for high attention and effective treatment methods in the medical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Elisabeth A. George, Leslie Castelo-Soccio, Elana Putterman, Helena Kuhn, Carlos Wambier, Abrar Qureshi, Eunyoung Cho
Summary: This study revealed significant associations between AA flare frequency and UV index, precipitation, number of days with rain, number of days with sun, and air pressure. Patients with atopic comorbidities showed stronger correlations with UV index and precipitation, suggesting they may be more susceptible to climate influences. New correlations appeared with temperature, wind speed, and UV index of the prior month, indicating potential mediating effects of climate factors on the seasonal pattern of AA flares. Patients without atopic comorbidities generally exhibited weaker and non-significant correlations between climate and AA flare frequency.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Lena Moebus, Elke Rodriguez, Inken Harder, Nicole Boraczynski, Silke Szymczak, Matthias Huebenthal, Dora Stoelzl, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger
Summary: This study explored the blood transcriptomic features of moderate to severe atopic dermatitis (AD). The results showed that AD patients exhibited pronounced inflammatory expression signatures and could be stratified into eosinophilic and noneosinophilic endotypes. Additionally, treatment strategies for the eosinophil-high endotype may require more attention to the restoration of natural killer cell function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Daphne S. Bakker, Stefan Nierkens, Edward F. Knol, Barbara Giovannone, Eveline M. Delemarre, Jorien van der Schaft, Femke van Wijk, Marjolein S. De Bruin-Weller, Julia Drylewicz, Judith L. Thijs
Summary: Atopic dermatitis (AD) is highly heterogeneous and can be stratified into biomarker-based endotypes. Through biomarker analysis, we identified four distinct clusters of AD patients, suggesting the potential for personalized therapies based on immunopathology.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Sheng Wan, Wen Xu, Bo Xie, Cuiping Guan, Xiuzu Song
Summary: Cytotoxic T lymphocyte and regulatory T (T-reg) cell deficiency are both implicated in the etiopathogenesis of alopecia areata (AA). Impaired T-reg cells in the lesional scalp result in dysregulated local immunity and hair follicle regeneration disorders. New strategies, such as CAR-T-reg cells and low-dose IL-2 formulations, are being explored to boost T-reg cells and stimulate hair regeneration for AA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Dermatology
Rong Sun, Deqi Kong
Summary: This systematic review and meta-analysis examined the association between atopic dermatitis (AD) and alopecia areata (AA). Through a comprehensive search, 29 studies with a total of 11,233,448 participants were included in the analysis. The meta-analysis showed that the prevalence of AD in patients with AA was 11.2% and the prevalence of AA in patients with AD was 3.2%. Age was found to affect the incidence of AD in AA patients. There was a significant association between AD and AA when AA was the exposure factor, as well as when AD was the exposure factor. This study provides important clinical reference for disease prevention and control.
Article
Allergy
Yael Renert-Yuval, Ana B. Pavel, Ester Del Duca, Paola Facheris, Angel D. Pagan, Swaroop Bose, Pedro J. Gomez-Arias, Michael Angelov, Jennifer Bares, Margo Chima, Yeriel D. Estrada, Sandra Garcet, Mark G. Lebwohl, James G. Krueger, Emma Guttman-Yassky
Summary: This study demonstrated the efficacy of dupilumab in treating alopecia areata (AA) by observing changes in scalp biomarkers. Dupilumab was found to suppress cellular infiltrates, downregulate Th2-related markers, and upregulate hair keratins. The efficacy was more pronounced in atopic AA patients.
Article
Dermatology
Ana B. Pavel, Lisa Zhou, Aisleen Diaz, Benjamin Ungar, Joshua Dan, Helen He, Yeriel D. Estrada, Hui Xu, Marie Fernandes, Yael Renert-Yuval, James G. Krueger, Emma Guttman-Yassky
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2020)
Article
Allergy
Jacob W. Glickman, Celina Dubin, Joseph Han, Dante Dahabreh, Sandra Garcet, James G. Krueger, Ana B. Pavel, Emma Guttman-Yassky
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Dermatology
Changxiong J. Guo, Madison R. Mack, Landon K. Oetjen, Anna M. Trier, Martha L. Council, Ana B. Pavel, Emma Guttman-Yassky, Brian S. Kim, Qin Liu
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Dermatology
Michelle S. Min, Jianni Wu, Helen He, Juan Luis Sanz-Cabanillas, Ester Del Duca, Ning Zhang, Yael Renert-Yuval, Ana B. Pavel, Mark Lebwohl, Emma Guttman-Yassky
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2020)
Letter
Dermatology
A. Diaz, K. Tan, H. He, H. Xu, I. Cueto, A. B. Pavel, J. G. Krueger, E. Guttman-Yassky
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Allergy
Benjamin Ungar, Ana B. Pavel, Randall Li, Grace Kimmel, John Nia, Peter Hashim, Hee Jin Kim, Margot Chima, Anjali S. Vekaria, Yeriel Estrada, Hui Xu, Xiangyu Peng, Giselle K. Singer, Danielle Baum, Yasaman Mansouri, Mark Taliercio, Emma Guttman-Yassky
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Dermatology
Jacob W. Glickman, Celina Dubin, Yael Renert-Yuval, Dante Dahabreh, Grace W. Kimmel, Kelsey Auyeung, Yeriel D. Estrada, Giselle Singer, James G. Krueger, Ana B. Pavel, Emma Guttman-Yassky
Summary: This study identified abnormality in moderate to severe alopecia areata (AA) and associated circulatory biomarkers. The results show systemic immune, cardiovascular, and atherosclerosis biomarker dysregulation in AA patients, indicating the necessity for systemic treatment approaches.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Allergy
Ana B. Pavel, Yael Renert-Yuval, Jianni Wu, Ester Del Duca, Aisleen Diaz, Rachel Lefferdink, Milie M. Fang, Talia Canter, Stephanie M. Rangel, Ning Zhang, James G. Krueger, Amy S. Paller, Emma Guttman-Yassky
Summary: Global transcriptomic profiling using tape strips in early-onset pediatric AD reveals immune and barrier alterations in both lesional and nonlesional skin, with significant dysregulation of Th2 and Th22/Th17-related genes. This approach provides insight into disease pathomechanisms and cutaneous disease activity, highlighting the potential utility of tape strips in studying pediatric AD.
Letter
Allergy
Ana B. Pavel, Jianni Wu, Yael Renert-Yuval, Ester Del Duca, Jacob W. Glickman, Rachel L. Miller, Amy S. Paller, James G. Krueger, Emma Guttman-Yassky
Article
Allergy
Helen He, Robert Bissonnette, Jianni Wu, Aisleen Diaz, Etienne Saint-Cyr Proulx, Catherine Maari, Carolyn Jack, Maudeline Louis, Yeriel Estrada, James G. Krueger, Ning Zhang, Ana B. Pavel, Emma Guttman-Yassky
Summary: This study utilized RNA-seq analysis of tape strips from lesional and nonlesional skin of patients with moderate-to-severe AD and psoriasis, revealing distinct immune and barrier signatures in the two diseases. The findings suggest the potential utility of tape strips as a minimally invasive alternative to biopsies for detecting disease biomarkers. Differences in gene expression profiles between AD and psoriasis highlight the unique pathophysiological mechanisms of these two skin disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Helen He, Ester Del Duca, Aisleen Diaz, Hyun Je Kim, Jesus Gay-Mimbrera, Ning Zhang, Jianni Wu, Jessica Beaziz, Yeriel Estrada, James G. Krueger, Ana B. Pavel, Juan Ruano, Emma Guttman-Yassky
Summary: This study found that markers of epidermal hyperplasia and T-cell/dendritic cell infiltration were increased in the skin tissues of all AD patients, regardless of disease severity. Levels of T(H)2/T(H)22 cytokines were significantly elevated in both lesional and nonlesional skin of all patients, while T(H)1 and T(H)17 markers were increased only in lesional skin of mild AD patients. Blood profiles showed gradual increases in inflammatory markers in moderate and severe AD patients, but no significant differences were observed in mild AD patients compared to healthy controls.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Letter
Allergy
Caroline Meyer Olesen, Ana B. Pavel, Jianni Wu, Daniela Mikhaylov, Ester Del Duca, Yeriel Estrada, James G. Krueger, Ning Zhang, Maja-Lisa Clausen, Tove Agner, Emma Guttman-Yassky
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Letter
Allergy
Jacob W. Glickman, Ana B. Pavel, Emma Guttman-Yassky, Rachel L. Miller
Article
Dermatology
Paola Morelli, Marco Gaspari, Caterina Gabriele, Stefano Dastoli, Luigi Bennardo, Ana Brandusa Pavel, Cataldo Patruno, Ester Del Duca, Steven P. Nistico
Summary: The study investigated the proteomic profile of the skin barrier in atopic dermatitis (AD) patients, revealing various abnormalities including downregulation of proteins, lipid metabolism disturbances, imbalance of antioxidant and inflammatory processes, among others. This research offers a new perspective on the pathomechanisms of AD by identifying a unique signature in the skin barrier of AD patients.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Madeline Kim, Daniela Mikhaylov, Stephanie M. Rangel, Ana B. Pavel, Helen He, Yael Renert-Yuval, Ester Del Duca, Kunal Malik, Thy Huynh, Erin Ibler, Mary Sun, Ning Zhang, Yeriel Estrada, James Krueger, Amy S. Paller, Emma Guttman-Yassky
Summary: The study provides comprehensive characterization of skin from different subtypes of ichthyosis, revealing shared inflammatory and barrier function abnormalities. These findings contribute to the understanding of the pathogenesis of these subtypes and inform the development of subtype-specific treatments.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)